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8G26

Crystal Structure of Cathepsin-G and Neutrophil Elastase Inhibited by S. aureus EapH2 at pH 8.5

Functional Information from GO Data
ChainGOidnamespacecontents
A0002003biological_processangiotensin maturation
A0002548biological_processmonocyte chemotaxis
A0004252molecular_functionserine-type endopeptidase activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005764cellular_componentlysosome
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006508biological_processproteolysis
A0006935biological_processchemotaxis
A0006955biological_processimmune response
A0008201molecular_functionheparin binding
A0008233molecular_functionpeptidase activity
A0008236molecular_functionserine-type peptidase activity
A0010494cellular_componentcytoplasmic stress granule
A0016020cellular_componentmembrane
A0016485biological_processprotein processing
A0016787molecular_functionhydrolase activity
A0019221biological_processcytokine-mediated signaling pathway
A0019731biological_processantibacterial humoral response
A0022617biological_processextracellular matrix disassembly
A0030141cellular_componentsecretory granule
A0030168biological_processplatelet activation
A0031012cellular_componentextracellular matrix
A0035578cellular_componentazurophil granule lumen
A0035590biological_processpurinergic nucleotide receptor signaling pathway
A0042119biological_processneutrophil activation
A0042742biological_processdefense response to bacterium
A0048018molecular_functionreceptor ligand activity
A0050829biological_processdefense response to Gram-negative bacterium
A0050830biological_processdefense response to Gram-positive bacterium
A0050868biological_processnegative regulation of T cell activation
A0051604biological_processprotein maturation
A0070062cellular_componentextracellular exosome
A0071222biological_processcellular response to lipopolysaccharide
A0089720molecular_functioncaspase binding
A0098786biological_processbiofilm matrix disassembly
A1901731biological_processpositive regulation of platelet aggregation
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0002020molecular_functionprotease binding
B0002438biological_processacute inflammatory response to antigenic stimulus
B0002523biological_processleukocyte migration involved in inflammatory response
B0002812biological_processbiosynthetic process of antibacterial peptides active against Gram-negative bacteria
B0003714molecular_functiontranscription corepressor activity
B0004175molecular_functionendopeptidase activity
B0004252molecular_functionserine-type endopeptidase activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006508biological_processproteolysis
B0006874biological_processintracellular calcium ion homeostasis
B0006909biological_processphagocytosis
B0008201molecular_functionheparin binding
B0008233molecular_functionpeptidase activity
B0008236molecular_functionserine-type peptidase activity
B0009411biological_processresponse to UV
B0009986cellular_componentcell surface
B0016787molecular_functionhydrolase activity
B0017053cellular_componenttranscription repressor complex
B0019955molecular_functioncytokine binding
B0022617biological_processextracellular matrix disassembly
B0030141cellular_componentsecretory granule
B0030163biological_processprotein catabolic process
B0031012cellular_componentextracellular matrix
B0031410cellular_componentcytoplasmic vesicle
B0031452biological_processnegative regulation of heterochromatin formation
B0032682biological_processnegative regulation of chemokine production
B0032717biological_processnegative regulation of interleukin-8 production
B0032757biological_processpositive regulation of interleukin-8 production
B0035578cellular_componentazurophil granule lumen
B0035580cellular_componentspecific granule lumen
B0042582cellular_componentazurophil granule
B0042742biological_processdefense response to bacterium
B0043406biological_processpositive regulation of MAP kinase activity
B0045335cellular_componentphagocytic vesicle
B0048661biological_processpositive regulation of smooth muscle cell proliferation
B0050728biological_processnegative regulation of inflammatory response
B0050922biological_processnegative regulation of chemotaxis
B0070062cellular_componentextracellular exosome
B0070269biological_processpyroptotic inflammatory response
B0070944biological_processneutrophil-mediated killing of bacterium
B0070945biological_processneutrophil-mediated killing of gram-negative bacterium
B0070947biological_processneutrophil-mediated killing of fungus
B0140644cellular_componentneutrophil extracellular trap
B0140645biological_processneutrophil extracellular trap formation
B1903238biological_processpositive regulation of leukocyte tethering or rolling
Functional Information from PROSITE/UniProt
site_idPS00134
Number of Residues6
DetailsTRYPSIN_HIS Serine proteases, trypsin family, histidine active site. MSAAHC
ChainResidueDetails
BMET65-CYS70
ALEU55-CYS60

site_idPS00135
Number of Residues12
DetailsTRYPSIN_SER Serine proteases, trypsin family, serine active site. GVcfGDSGSPLV
ChainResidueDetails
BGLY195-VAL206
AALA190-LEU201

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues439
DetailsDomain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues18
DetailsRegion: {"description":"Important for antimicrobial activity","evidences":[{"source":"PubMed","id":"2116408","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues3
DetailsActive site: {"description":"Charge relay system","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) (paucimannose) asparagine; alternate","evidences":[{"source":"PubMed","id":"26274980","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues3
DetailsActive site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"2911584","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"26274980","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3550808","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3550808","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

247947

PDB entries from 2026-01-21

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