8FY1
E3:PROTAC:target ternary complex structure (VCB/753b/BCL-2)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0001222 | molecular_function | transcription corepressor binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006367 | biological_process | transcription initiation at RNA polymerase II promoter |
| B | 0006368 | biological_process | transcription elongation by RNA polymerase II |
| B | 0016567 | biological_process | protein ubiquitination |
| B | 0030891 | cellular_component | VCB complex |
| B | 0031462 | cellular_component | Cul2-RING ubiquitin ligase complex |
| B | 0031466 | cellular_component | Cul5-RING ubiquitin ligase complex |
| B | 0031625 | molecular_function | ubiquitin protein ligase binding |
| B | 0032436 | biological_process | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| B | 0065003 | biological_process | protein-containing complex assembly |
| B | 0070449 | cellular_component | elongin complex |
| B | 0140958 | biological_process | target-directed miRNA degradation |
Functional Information from PROSITE/UniProt
| site_id | PS01080 |
| Number of Residues | 19 |
| Details | BH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. LFrDGv.NWGRIVAFFeFGG |
| Chain | Residue | Details |
| D | LEU137-GLY155 |
| site_id | PS01258 |
| Number of Residues | 12 |
| Details | BH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WIqdnGGWDaFV |
| Chain | Residue | Details |
| D | TRP188-VAL199 |
| site_id | PS01259 |
| Number of Residues | 15 |
| Details | BH3 Apoptosis regulator, Bcl-2 family BH3 motif signature. VhltLRqAGDDFSRR |
| Chain | Residue | Details |
| D | VAL93-ARG107 |
| site_id | PS01260 |
| Number of Residues | 21 |
| Details | BH4_1 Apoptosis regulator, Bcl-2 family BH4 motif signature. DNREIVmKYIHYKLSQRGYeW |
| Chain | Residue | Details |
| D | ASP10-TRP30 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | SITE: Cleavage; by caspase-3 |
| Chain | Residue | Details |
| D | ASP34 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by MAPK8 => ECO:0000269|PubMed:18570871 |
| Chain | Residue | Details |
| D | THR69 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by MAPK8 and PKC => ECO:0000269|PubMed:18570871 |
| Chain | Residue | Details |
| D | SER70 | |
| B | SER111 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by MAPK8 => ECO:0000269|PubMed:18570871 |
| Chain | Residue | Details |
| D | SER87 |
