8FWT

Structure of the amino terminal domain of kainate receptor GluK2 in complex with the positive allosteric modulator BPAM344 and competitive antagonist DNQX

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
A	0038023	molecular_function	signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
B	0038023	molecular_function	signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane
C	0038023	molecular_function	signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0015276	molecular_function	ligand-gated monoatomic ion channel activity
D	0016020	cellular_component	membrane
D	0038023	molecular_function	signaling receptor activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2752
Details	TOPO_DOM: Extracellular => ECO:0000305|PubMed:8163463

Chain	Residue	Details
A	THR32-PRO561
A	THR660-ASN819
B	THR32-PRO561
B	THR660-ASN819
C	THR32-PRO561
C	THR660-ASN819
D	THR32-PRO561
D	THR660-ASN819

---

site_id	SWS_FT_FI2
Number of Residues	240
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
A	ASP562-ALA582
D	ASP562-ALA582
D	ILE639-LEU659
D	ILE820-GLY840
A	ILE639-LEU659
A	ILE820-GLY840
B	ASP562-ALA582
B	ILE639-LEU659
B	ILE820-GLY840
C	ASP562-ALA582
C	ILE639-LEU659
C	ILE820-GLY840

---

site_id	SWS_FT_FI3
Number of Residues	488
Details	TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:8163463

Chain	Residue	Details
A	ARG583-GLY638
A	GLU841-ALA908
B	ARG583-GLY638
B	GLU841-ALA908
C	ARG583-GLY638
C	GLU841-ALA908
D	ARG583-GLY638
D	GLU841-ALA908

---

site_id	SWS_FT_FI4
Number of Residues	24
Details	BINDING: BINDING => ECO:0000269|PubMed:15721240, ECO:0000269|PubMed:17115050, ECO:0007744|PDB:1S50, ECO:0007744|PDB:1S7Y, ECO:0007744|PDB:2I0B, ECO:0007744|PDB:2I0C

Chain	Residue	Details
A	PRO516
B	ALA689
B	THR690
B	GLU738
C	PRO516
C	ALA518
C	ARG523
C	ALA689
C	THR690
C	GLU738
D	PRO516
A	ALA518
D	ALA518
D	ARG523
D	ALA689
D	THR690
D	GLU738
A	ARG523
A	ALA689
A	THR690
A	GLU738
B	PRO516
B	ALA518
B	ARG523

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000250|UniProtKB:Q13002

Chain	Residue	Details
A	SER846
A	SER868
B	SER846
B	SER868
C	SER846
C	SER868
D	SER846
D	SER868

---

site_id	SWS_FT_FI6
Number of Residues	12
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21791290

Chain	Residue	Details
A	ASN67
D	ASN67
D	ASN378
D	ASN412
A	ASN378
A	ASN412
B	ASN67
B	ASN378
B	ASN412
C	ASN67
C	ASN378
C	ASN412

---

site_id	SWS_FT_FI7
Number of Residues	16
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN73
C	ASN275
C	ASN430
C	ASN546
D	ASN73
D	ASN275
D	ASN430
D	ASN546
A	ASN275
A	ASN430
A	ASN546
B	ASN73
B	ASN275
B	ASN430
B	ASN546
C	ASN73

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15677325

Chain	Residue	Details
A	ASN423
B	ASN423
C	ASN423
D	ASN423

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15677325, ECO:0000269|PubMed:8163463

Chain	Residue	Details
A	ASN751
B	ASN751
C	ASN751
D	ASN751

---

site_id	SWS_FT_FI10
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) => ECO:0000269|PubMed:17486098

Chain	Residue	Details
A	LYS886
B	LYS886
C	LYS886
D	LYS886

---