8FPL

LBD conformation 2 (LBDconf2) of GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 10mM CaCl2, 150mM NaCl, 1mM MgCl2, 330uM CTZ, and 100uM CNQX (Closed-CaNaMg)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
A	0038023	molecular_function	signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
B	0038023	molecular_function	signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane
C	0038023	molecular_function	signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0015276	molecular_function	ligand-gated monoatomic ion channel activity
D	0016020	cellular_component	membrane
D	0038023	molecular_function	signaling receptor activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2780
Details	TOPO_DOM: Extracellular

Chain	Residue	Details
B	VAL1-ALA522
B	THR617-ASN791
C	VAL1-ALA522
C	THR617-ASN791
A	VAL1-ALA522
A	THR617-ASN791
D	VAL1-ALA522
D	THR617-ASN791

---

site_id	SWS_FT_FI2
Number of Residues	160
Details	TRANSMEM: Helical

Chain	Residue	Details
B	TYR523-VAL543
B	LEU596-TYR616
C	TYR523-VAL543
C	LEU596-TYR616
A	TYR523-VAL543
A	LEU596-TYR616
D	TYR523-VAL543
D	LEU596-TYR616

---

site_id	SWS_FT_FI3
Number of Residues	320
Details	TOPO_DOM: Cytoplasmic

Chain	Residue	Details
B	SER544-GLU570
D	SER544-GLU570
D	ASP590-SER595
D	GLU813-GLY862
B	ASP590-SER595
B	GLU813-GLY862
C	SER544-GLU570
C	ASP590-SER595
C	GLU813-GLY862
A	SER544-GLU570
A	ASP590-SER595
A	GLU813-GLY862

---

site_id	SWS_FT_FI4
Number of Residues	60
Details	INTRAMEM: Helical; Pore-forming

Chain	Residue	Details
B	PHE571-GLN586
C	PHE571-GLN586
A	PHE571-GLN586
D	PHE571-GLN586

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	INTRAMEM:

Chain	Residue	Details
B	GLN587-CYS589
C	GLN587-CYS589
A	GLN587-CYS589
D	GLN587-CYS589

---

site_id	SWS_FT_FI6
Number of Residues	80
Details	TRANSMEM: Helical; Name=M4

Chain	Residue	Details
B	VAL792-ILE812
C	VAL792-ILE812
A	VAL792-ILE812
D	VAL792-ILE812

---

site_id	SWS_FT_FI7
Number of Residues	24
Details	BINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO

Chain	Residue	Details
B	PRO478
C	SER654
C	THR655
C	GLU705
A	PRO478
A	THR480
A	ARG485
A	SER654
A	THR655
A	GLU705
D	PRO478
B	THR480
D	THR480
D	ARG485
D	SER654
D	THR655
D	GLU705
B	ARG485
B	SER654
B	THR655
B	GLU705
C	PRO478
C	THR480
C	ARG485

---

site_id	SWS_FT_FI8
Number of Residues	12
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405

Chain	Residue	Details
B	ARG453
D	ARG453
D	ARG660
D	LYS752
B	ARG660
B	LYS752
C	ARG453
C	ARG660
C	LYS752
A	ARG453
A	ARG660
A	LYS752

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405

Chain	Residue	Details
B	ILE633
C	ILE633
A	ILE633
D	ILE633

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293

Chain	Residue	Details
B	SER662
C	SER662
A	SER662
D	SER662

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293

Chain	Residue	Details
B	SER696
C	SER696
A	SER696
D	SER696

---

site_id	SWS_FT_FI12
Number of Residues	12
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P23819

Chain	Residue	Details
B	SER839
D	SER839
D	SER842
D	SER865
B	SER842
B	SER865
C	SER839
C	SER842
C	SER865
A	SER839
A	SER842
A	SER865

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:15240807, ECO:0000269|PubMed:20547133

Chain	Residue	Details
B	TYR861
C	TYR861
A	TYR861
D	TYR861

---

site_id	SWS_FT_FI14
Number of Residues	8
Details	LIPID: S-palmitoyl cysteine => ECO:0000250

Chain	Residue	Details
B	CYS589
B	CYS815
C	CYS589
C	CYS815
A	CYS589
A	CYS815
D	CYS589
D	CYS815

---

site_id	SWS_FT_FI15
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21317873

Chain	Residue	Details
B	ASN235
C	ASN235
A	ASN235
D	ASN235

---

site_id	SWS_FT_FI16
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19946266, ECO:0000269|PubMed:21317873, ECO:0000269|PubMed:25103405

Chain	Residue	Details
B	ASN349
C	ASN349
A	ASN349
D	ASN349

---

site_id	SWS_FT_FI17
Number of Residues	8
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
B	ASN385
B	ASN392
C	ASN385
C	ASN392
A	ASN385
A	ASN392
D	ASN385
D	ASN392

---