8FOR
Crystal Structure of Kemp Eliminase KE70-core with bound transition state analogue
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004139 | molecular_function | deoxyribose-phosphate aldolase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0009264 | biological_process | deoxyribonucleotide catabolic process |
| A | 0016829 | molecular_function | lyase activity |
| B | 0004139 | molecular_function | deoxyribose-phosphate aldolase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0009264 | biological_process | deoxyribonucleotide catabolic process |
| B | 0016829 | molecular_function | lyase activity |
| C | 0004139 | molecular_function | deoxyribose-phosphate aldolase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0009264 | biological_process | deoxyribonucleotide catabolic process |
| C | 0016829 | molecular_function | lyase activity |
| D | 0004139 | molecular_function | deoxyribose-phosphate aldolase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0009264 | biological_process | deoxyribonucleotide catabolic process |
| D | 0016829 | molecular_function | lyase activity |
| E | 0004139 | molecular_function | deoxyribose-phosphate aldolase activity |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0009264 | biological_process | deoxyribonucleotide catabolic process |
| E | 0016829 | molecular_function | lyase activity |
| F | 0004139 | molecular_function | deoxyribose-phosphate aldolase activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0009264 | biological_process | deoxyribonucleotide catabolic process |
| F | 0016829 | molecular_function | lyase activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_00592","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11598300","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Active site: {"description":"Schiff-base intermediate with acetaldehyde","evidences":[{"source":"HAMAP-Rule","id":"MF_00592","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11598300","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15476818","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_00592","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11598300","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"15476818","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"18723842","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 3 |
| Details | M-CSA 613 |
| Chain | Residue | Details |
| A | ALA103 | increase nucleophilicity, proton acceptor, proton donor, proton relay |
| A | VAL168 | covalently attached, electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor, proton donor |
| A | ILE202 | increase nucleophilicity, proton acceptor, proton donor, proton relay |
| site_id | MCSA2 |
| Number of Residues | 3 |
| Details | M-CSA 613 |
| Chain | Residue | Details |
| B | ALA103 | increase nucleophilicity, proton acceptor, proton donor, proton relay |
| B | VAL168 | covalently attached, electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor, proton donor |
| B | ILE202 | increase nucleophilicity, proton acceptor, proton donor, proton relay |
| site_id | MCSA3 |
| Number of Residues | 3 |
| Details | M-CSA 613 |
| Chain | Residue | Details |
| C | ALA103 | increase nucleophilicity, proton acceptor, proton donor, proton relay |
| C | VAL168 | covalently attached, electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor, proton donor |
| C | ILE202 | increase nucleophilicity, proton acceptor, proton donor, proton relay |
| site_id | MCSA4 |
| Number of Residues | 3 |
| Details | M-CSA 613 |
| Chain | Residue | Details |
| D | ALA103 | increase nucleophilicity, proton acceptor, proton donor, proton relay |
| D | VAL168 | covalently attached, electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor, proton donor |
| D | ILE202 | increase nucleophilicity, proton acceptor, proton donor, proton relay |
| site_id | MCSA5 |
| Number of Residues | 3 |
| Details | M-CSA 613 |
| Chain | Residue | Details |
| E | ALA103 | increase nucleophilicity, proton acceptor, proton donor, proton relay |
| E | VAL168 | covalently attached, electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor, proton donor |
| E | ILE202 | increase nucleophilicity, proton acceptor, proton donor, proton relay |
| site_id | MCSA6 |
| Number of Residues | 3 |
| Details | M-CSA 613 |
| Chain | Residue | Details |
| F | ALA103 | increase nucleophilicity, proton acceptor, proton donor, proton relay |
| F | VAL168 | covalently attached, electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor, proton donor |
| F | ILE202 | increase nucleophilicity, proton acceptor, proton donor, proton relay |
