8FND
Structure of E138K HIV-1 intasome with Dolutegravir bound
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0015074 | biological_process | DNA integration |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0015074 | biological_process | DNA integration |
| C | 0003676 | molecular_function | nucleic acid binding |
| C | 0008270 | molecular_function | zinc ion binding |
| C | 0015074 | biological_process | DNA integration |
| D | 0003676 | molecular_function | nucleic acid binding |
| D | 0008270 | molecular_function | zinc ion binding |
| D | 0015074 | biological_process | DNA integration |
| G | 0003676 | molecular_function | nucleic acid binding |
| G | 0008270 | molecular_function | zinc ion binding |
| G | 0015074 | biological_process | DNA integration |
| H | 0003676 | molecular_function | nucleic acid binding |
| H | 0008270 | molecular_function | zinc ion binding |
| H | 0015074 | biological_process | DNA integration |
| I | 0003676 | molecular_function | nucleic acid binding |
| I | 0008270 | molecular_function | zinc ion binding |
| I | 0015074 | biological_process | DNA integration |
| J | 0003676 | molecular_function | nucleic acid binding |
| J | 0008270 | molecular_function | zinc ion binding |
| J | 0015074 | biological_process | DNA integration |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648 |
| Chain | Residue | Details |
| A | THR-46 | |
| B | THR-46 | |
| C | THR-46 | |
| D | THR-46 | |
| G | THR-46 | |
| H | THR-46 | |
| I | THR-46 | |
| J | THR-46 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692 |
| Chain | Residue | Details |
| A | SER-44 | |
| B | SER-44 | |
| C | SER-44 | |
| D | SER-44 | |
| G | SER-44 | |
| H | SER-44 | |
| I | SER-44 | |
| J | SER-44 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER-37 | |
| G | SER-36 | |
| H | SER-37 | |
| H | SER-36 | |
| I | SER-37 | |
| I | SER-36 | |
| J | SER-37 | |
| J | SER-36 | |
| A | SER-36 | |
| B | SER-37 | |
| B | SER-36 | |
| C | SER-37 | |
| C | SER-36 | |
| D | SER-37 | |
| D | SER-36 | |
| G | SER-37 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | THR-29 | |
| B | THR-29 | |
| C | THR-29 | |
| D | THR-29 | |
| G | THR-29 | |
| H | THR-29 | |
| I | THR-29 | |
| J | THR-29 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER-24 | |
| B | SER-24 | |
| C | SER-24 | |
| D | SER-24 | |
| G | SER-24 | |
| H | SER-24 | |
| I | SER-24 | |
| J | SER-24 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 16 |
| Details | MOD_RES: Omega-N-methylarginine => ECO:0000250|UniProtKB:Q61033 |
| Chain | Residue | Details |
| A | GLN-17 | |
| G | ARG-15 | |
| H | GLN-17 | |
| H | ARG-15 | |
| I | GLN-17 | |
| I | ARG-15 | |
| J | GLN-17 | |
| J | ARG-15 | |
| A | ARG-15 | |
| B | GLN-17 | |
| B | ARG-15 | |
| C | GLN-17 | |
| C | ARG-15 | |
| D | GLN-17 | |
| D | ARG-15 | |
| G | GLN-17 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 328 |
| Details | ZN_FING: Integrase-type => ECO:0000255|PROSITE-ProRule:PRU00450 |
| Chain | Residue | Details |
| A | ASP3-GLN44 | |
| B | ASP3-GLN44 | |
| C | ASP3-GLN44 | |
| D | ASP3-GLN44 | |
| G | ASP3-GLN44 | |
| H | ASP3-GLN44 | |
| I | ASP3-GLN44 | |
| J | ASP3-GLN44 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 376 |
| Details | DNA_BIND: Integrase-type => ECO:0000255|PROSITE-ProRule:PRU00506 |
| Chain | Residue | Details |
| A | PHE223-ASP270 | |
| B | PHE223-ASP270 | |
| C | PHE223-ASP270 | |
| D | PHE223-ASP270 | |
| G | PHE223-ASP270 | |
| H | PHE223-ASP270 | |
| I | PHE223-ASP270 | |
| J | PHE223-ASP270 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 32 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00450 |
| Chain | Residue | Details |
| A | HIS12 | |
| C | HIS16 | |
| C | CYS40 | |
| C | CYS43 | |
| D | HIS12 | |
| D | HIS16 | |
| D | CYS40 | |
| D | CYS43 | |
| G | HIS12 | |
| G | HIS16 | |
| G | CYS40 | |
| A | HIS16 | |
| G | CYS43 | |
| H | HIS12 | |
| H | HIS16 | |
| H | CYS40 | |
| H | CYS43 | |
| I | HIS12 | |
| I | HIS16 | |
| I | CYS40 | |
| I | CYS43 | |
| J | HIS12 | |
| A | CYS40 | |
| J | HIS16 | |
| J | CYS40 | |
| J | CYS43 | |
| A | CYS43 | |
| B | HIS12 | |
| B | HIS16 | |
| B | CYS40 | |
| B | CYS43 | |
| C | HIS12 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 16 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ASP64 | |
| G | ASP116 | |
| H | ASP64 | |
| H | ASP116 | |
| I | ASP64 | |
| I | ASP116 | |
| J | ASP64 | |
| J | ASP116 | |
| A | ASP116 | |
| B | ASP64 | |
| B | ASP116 | |
| C | ASP64 | |
| C | ASP116 | |
| D | ASP64 | |
| D | ASP116 | |
| G | ASP64 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P04585 |
| Chain | Residue | Details |
| A | GLU152 | |
| B | GLU152 | |
| C | GLU152 | |
| D | GLU152 | |
| G | GLU152 | |
| H | GLU152 | |
| I | GLU152 | |
| J | GLU152 |
