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8FII

Wild type APOBEC3A in complex with TT(FdZ)-hairpin inhibitor (crystal form 1)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000932cellular_componentP-body
A0003723molecular_functionRNA binding
A0003824molecular_functioncatalytic activity
A0004126molecular_functioncytidine deaminase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0008270molecular_functionzinc ion binding
A0010526biological_processretrotransposon silencing
A0016554biological_processcytidine to uridine editing
A0016787molecular_functionhydrolase activity
A0044029biological_processpositive regulation of gene expression via chromosomal CpG island demethylation
A0044355biological_processclearance of foreign intracellular DNA
A0045071biological_processnegative regulation of viral genome replication
A0045087biological_processinnate immune response
A0045869biological_processnegative regulation of single stranded viral RNA replication via double stranded DNA intermediate
A0046872molecular_functionmetal ion binding
A0051607biological_processdefense response to virus
A0070383biological_processDNA cytosine deamination
B0000932cellular_componentP-body
B0003723molecular_functionRNA binding
B0003824molecular_functioncatalytic activity
B0004126molecular_functioncytidine deaminase activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0008270molecular_functionzinc ion binding
B0010526biological_processretrotransposon silencing
B0016554biological_processcytidine to uridine editing
B0016787molecular_functionhydrolase activity
B0044029biological_processpositive regulation of gene expression via chromosomal CpG island demethylation
B0044355biological_processclearance of foreign intracellular DNA
B0045071biological_processnegative regulation of viral genome replication
B0045087biological_processinnate immune response
B0045869biological_processnegative regulation of single stranded viral RNA replication via double stranded DNA intermediate
B0046872molecular_functionmetal ion binding
B0051607biological_processdefense response to virus
B0070383biological_processDNA cytosine deamination
Functional Information from PROSITE/UniProt
site_idPS00903
Number of Residues41
DetailsCYT_DCMP_DEAMINASES_1 Cytidine and deoxycytidylate deaminases zinc-binding region signature. HAElrFLdlvpslqldpaqiyrvtwfisws..........PCfswg....CageV
ChainResidueDetails
AHIS70-VAL110

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton donor => ECO:0000250
ChainResidueDetails
AGLU72
BGLU72

site_idSWS_FT_FI2
Number of Residues6
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AHIS70
ACYS101
ACYS106
BHIS70
BCYS101
BCYS106

226707

PDB entries from 2024-10-30

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