8FGI

Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with 4-(5-(2-(dimethylamino)ethyl)-2,3-difluorophenethyl)-6-methylpyrimidin-2-amine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004517	molecular_function	nitric-oxide synthase activity
A	0006809	biological_process	nitric oxide biosynthetic process
B	0004517	molecular_function	nitric-oxide synthase activity
B	0006809	biological_process	nitric oxide biosynthetic process

Functional Information from PROSITE/UniProt

site_id	PS60001
Number of Residues	8
Details	NOS Nitric oxide synthase (NOS) signature. RCVGRIqW

Chain	Residue	Details
A	ARG419-TRP426

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	BINDING: BINDING => ECO:0000269|PubMed:25286850, ECO:0007744|PDB:4D1N

Chain	Residue	Details
A	SER339
B	SER339
B	GLN483
B	TRP592
B	TYR593
B	GLU597
B	VAL682
B	TRP683
B	PHE696
B	TYR711
A	GLN483
A	TRP592
A	TYR593
A	GLU597
A	VAL682
A	TRP683
A	PHE696
A	TYR711

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: axial binding residue => ECO:0000269|PubMed:25286850, ECO:0007744|PDB:4D1N

Chain	Residue	Details
A	CYS420
B	CYS420

---