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8FG2

SARS-CoV-2 Nucleocapsid dimer structure determined from COVID-19 patients

Functional Information from GO Data
ChainGOidnamespacecontents
A0003723molecular_functionRNA binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005737cellular_componentcytoplasm
A0008266molecular_functionpoly(U) RNA binding
A0019013cellular_componentviral nucleocapsid
A0019028cellular_componentviral capsid
A0019074biological_processviral RNA genome packaging
A0030430cellular_componenthost cell cytoplasm
A0032688biological_processnegative regulation of interferon-beta production
A0035613molecular_functionRNA stem-loop binding
A0039709biological_processcytoplasmic capsid assembly
A0042288molecular_functionMHC class I protein binding
A0042612cellular_componentMHC class I protein complex
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0043232cellular_componentintracellular non-membrane-bounded organelle
A0043655cellular_componenthost extracellular space
A0044172cellular_componenthost cell endoplasmic reticulum-Golgi intermediate compartment
A0044177cellular_componenthost cell Golgi apparatus
A0044220cellular_componenthost cell perinuclear region of cytoplasm
A0052572biological_processresponse to host immune response
A0140311molecular_functionprotein sequestering activity
A0140693molecular_functionmolecular condensate scaffold activity
A1900227biological_processpositive regulation of NLRP3 inflammasome complex assembly
A1990904cellular_componentribonucleoprotein complex
B0003723molecular_functionRNA binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005737cellular_componentcytoplasm
B0008266molecular_functionpoly(U) RNA binding
B0019013cellular_componentviral nucleocapsid
B0019028cellular_componentviral capsid
B0019074biological_processviral RNA genome packaging
B0030430cellular_componenthost cell cytoplasm
B0032688biological_processnegative regulation of interferon-beta production
B0035613molecular_functionRNA stem-loop binding
B0039709biological_processcytoplasmic capsid assembly
B0042288molecular_functionMHC class I protein binding
B0042612cellular_componentMHC class I protein complex
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0043232cellular_componentintracellular non-membrane-bounded organelle
B0043655cellular_componenthost extracellular space
B0044172cellular_componenthost cell endoplasmic reticulum-Golgi intermediate compartment
B0044177cellular_componenthost cell Golgi apparatus
B0044220cellular_componenthost cell perinuclear region of cytoplasm
B0052572biological_processresponse to host immune response
B0140311molecular_functionprotein sequestering activity
B0140693molecular_functionmolecular condensate scaffold activity
B1900227biological_processpositive regulation of NLRP3 inflammasome complex assembly
B1990904cellular_componentribonucleoprotein complex
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:33264373, ECO:0007744|PDB:7ACS, ECO:0007744|PDB:7ACT
ChainResidueDetails
AARG92
AARG107
AARG149
BARG92
BARG107
BARG149

site_idSWS_FT_FI2
Number of Residues2
DetailsSITE: Cleavage (by host CASP6) => ECO:0000250|UniProtKB:P59595
ChainResidueDetails
AASP399
BASP399

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine; by host => ECO:0000255|HAMAP-Rule:MF_04096
ChainResidueDetails
ASER176
BSER176

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine; by host GSK3-alpha and GSK3-beta => ECO:0000269|PubMed:34593624
ChainResidueDetails
ASER206
BSER206

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PDB entries from 2024-10-30

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