8FF3
Amyloid-beta (1-40) fibrils derived from familial Dutch-type CAA patient (population B)
Functional Information from GO Data
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11274207, ECO:0000269|PubMed:26898943 |
| Chain | Residue | Details |
| b | GLY25 | |
| A | GLY33 | |
| B | GLY25 | |
| B | GLY33 | |
| b | GLY33 | |
| C | GLY25 | |
| C | GLY33 | |
| a | GLY25 | |
| a | GLY33 | |
| c | GLY25 | |
| c | GLY33 | |
| A | GLY25 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:10413512, ECO:0000305|PubMed:11274207 |
| Chain | Residue | Details |
| b | GLY29 | |
| C | GLY29 | |
| a | GLY29 | |
| c | GLY29 | |
| A | GLY29 | |
| B | GLY29 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10413512, ECO:0000269|PubMed:11274207, ECO:0000269|PubMed:26898943 |
| Chain | Residue | Details |
| b | ILE32 | |
| C | ILE32 | |
| a | ILE32 | |
| c | ILE32 | |
| A | ILE32 | |
| B | ILE32 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | SITE: Cleavage; by beta-secretase => ECO:0000305|PubMed:11851430 |
| Chain | Residue | Details |
| b | PHE19 | |
| C | PHE19 | |
| a | PHE19 | |
| c | PHE19 | |
| A | PHE19 | |
| B | PHE19 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | SITE: Cleavage; by caspase-6; when associated with variant 670-N-L-671 |
| Chain | Residue | Details |
| b | PHE20 | |
| C | PHE20 | |
| a | PHE20 | |
| c | PHE20 | |
| A | PHE20 | |
| B | PHE20 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | SITE: Cleavage; by ACE => ECO:0000269|PubMed:11604391, ECO:0000269|PubMed:16154999 |
| Chain | Residue | Details |
| b | SER26 | |
| C | SER26 | |
| a | SER26 | |
| c | SER26 | |
| A | SER26 | |
| B | SER26 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 6 |
| Details | SITE: Cleavage; by alpha-secretase => ECO:0000305|PubMed:11851430 |
| Chain | Residue | Details |
| b | MET35 | |
| C | MET35 | |
| a | MET35 | |
| c | MET35 | |
| A | MET35 | |
| B | MET35 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 6 |
| Details | SITE: Cleavage; by theta-secretase => ECO:0000269|PubMed:16816112 |
| Chain | Residue | Details |
| b | GLY38 | |
| C | GLY38 | |
| a | GLY38 | |
| c | GLY38 | |
| A | GLY38 | |
| B | GLY38 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 6 |
| Details | CARBOHYD: O-linked (Xyl...) (chondroitin sulfate) serine; in L-APP isoforms => ECO:0000269|PubMed:21712440 |
| Chain | Residue | Details |
| b | PHE4 | |
| C | PHE4 | |
| a | PHE4 | |
| c | PHE4 | |
| A | PHE4 | |
| B | PHE4 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 6 |
| Details | CARBOHYD: O-linked (HexNAc...) threonine; partial => ECO:0000269|PubMed:22576872 |
| Chain | Residue | Details |
| b | ASP7 | |
| C | ASP7 | |
| a | ASP7 | |
| c | ASP7 | |
| A | ASP7 | |
| B | ASP7 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 6 |
| Details | CARBOHYD: O-linked (GalNAc...) threonine; partial => ECO:0000269|PubMed:22576872, ECO:0000305|PubMed:21712440 |
| Chain | Residue | Details |
| b | GLU11 | |
| C | GLU11 | |
| a | GLU11 | |
| c | GLU11 | |
| A | GLU11 | |
| B | GLU11 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 6 |
| Details | CARBOHYD: O-linked (GalNAc...) serine; partial => ECO:0000269|PubMed:22576872, ECO:0000305|PubMed:21712440 |
| Chain | Residue | Details |
| b | GLN15 | |
| C | GLN15 | |
| a | GLN15 | |
| c | GLN15 | |
| A | GLN15 | |
| B | GLN15 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 6 |
| Details | CARBOHYD: O-linked (HexNAc...) tyrosine; partial => ECO:0000269|PubMed:22576872 |
| Chain | Residue | Details |
| b | GLY29 | |
| C | GLY29 | |
| a | GLY29 | |
| c | GLY29 | |
| A | GLY29 | |
| B | GLY29 |
