8FF2
Amyloid-beta (1-40) fibrils derived from a CAA patient
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016020 | cellular_component | membrane |
| B | 0016020 | cellular_component | membrane |
| C | 0016020 | cellular_component | membrane |
| D | 0016020 | cellular_component | membrane |
| E | 0016020 | cellular_component | membrane |
| F | 0016020 | cellular_component | membrane |
| G | 0016020 | cellular_component | membrane |
| I | 0016020 | cellular_component | membrane |
| J | 0016020 | cellular_component | membrane |
| K | 0016020 | cellular_component | membrane |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11274207, ECO:0000269|PubMed:26898943 |
| Chain | Residue | Details |
| A | GLY25 | |
| E | GLY33 | |
| F | GLY25 | |
| F | GLY33 | |
| G | GLY25 | |
| G | GLY33 | |
| I | GLY25 | |
| I | GLY33 | |
| J | GLY25 | |
| J | GLY33 | |
| K | GLY25 | |
| A | GLY33 | |
| K | GLY33 | |
| B | GLY25 | |
| B | GLY33 | |
| C | GLY25 | |
| C | GLY33 | |
| D | GLY25 | |
| D | GLY33 | |
| E | GLY25 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:10413512, ECO:0000305|PubMed:11274207 |
| Chain | Residue | Details |
| A | GLY29 | |
| K | GLY29 | |
| B | GLY29 | |
| C | GLY29 | |
| D | GLY29 | |
| E | GLY29 | |
| F | GLY29 | |
| G | GLY29 | |
| I | GLY29 | |
| J | GLY29 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10413512, ECO:0000269|PubMed:11274207, ECO:0000269|PubMed:26898943 |
| Chain | Residue | Details |
| A | ILE32 | |
| K | ILE32 | |
| B | ILE32 | |
| C | ILE32 | |
| D | ILE32 | |
| E | ILE32 | |
| F | ILE32 | |
| G | ILE32 | |
| I | ILE32 | |
| J | ILE32 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 10 |
| Details | SITE: Cleavage; by beta-secretase => ECO:0000305|PubMed:11851430 |
| Chain | Residue | Details |
| A | PHE19 | |
| K | PHE19 | |
| B | PHE19 | |
| C | PHE19 | |
| D | PHE19 | |
| E | PHE19 | |
| F | PHE19 | |
| G | PHE19 | |
| I | PHE19 | |
| J | PHE19 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 10 |
| Details | SITE: Cleavage; by caspase-6; when associated with variant 670-N-L-671 |
| Chain | Residue | Details |
| A | PHE20 | |
| K | PHE20 | |
| B | PHE20 | |
| C | PHE20 | |
| D | PHE20 | |
| E | PHE20 | |
| F | PHE20 | |
| G | PHE20 | |
| I | PHE20 | |
| J | PHE20 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 10 |
| Details | SITE: Cleavage; by ACE => ECO:0000269|PubMed:11604391, ECO:0000269|PubMed:16154999 |
| Chain | Residue | Details |
| A | SER26 | |
| K | SER26 | |
| B | SER26 | |
| C | SER26 | |
| D | SER26 | |
| E | SER26 | |
| F | SER26 | |
| G | SER26 | |
| I | SER26 | |
| J | SER26 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 10 |
| Details | SITE: Cleavage; by alpha-secretase => ECO:0000305|PubMed:11851430 |
| Chain | Residue | Details |
| A | MET35 | |
| K | MET35 | |
| B | MET35 | |
| C | MET35 | |
| D | MET35 | |
| E | MET35 | |
| F | MET35 | |
| G | MET35 | |
| I | MET35 | |
| J | MET35 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 10 |
| Details | SITE: Cleavage; by theta-secretase => ECO:0000269|PubMed:16816112 |
| Chain | Residue | Details |
| A | GLY38 | |
| K | GLY38 | |
| B | GLY38 | |
| C | GLY38 | |
| D | GLY38 | |
| E | GLY38 | |
| F | GLY38 | |
| G | GLY38 | |
| I | GLY38 | |
| J | GLY38 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 10 |
| Details | CARBOHYD: O-linked (Xyl...) (chondroitin sulfate) serine; in L-APP isoforms => ECO:0000269|PubMed:21712440 |
| Chain | Residue | Details |
| A | PHE4 | |
| K | PHE4 | |
| B | PHE4 | |
| C | PHE4 | |
| D | PHE4 | |
| E | PHE4 | |
| F | PHE4 | |
| G | PHE4 | |
| I | PHE4 | |
| J | PHE4 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 10 |
| Details | CARBOHYD: O-linked (HexNAc...) threonine; partial => ECO:0000269|PubMed:22576872 |
| Chain | Residue | Details |
| A | ASP7 | |
| K | ASP7 | |
| B | ASP7 | |
| C | ASP7 | |
| D | ASP7 | |
| E | ASP7 | |
| F | ASP7 | |
| G | ASP7 | |
| I | ASP7 | |
| J | ASP7 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 10 |
| Details | CARBOHYD: O-linked (GalNAc...) threonine; partial => ECO:0000269|PubMed:22576872, ECO:0000305|PubMed:21712440 |
| Chain | Residue | Details |
| A | GLU11 | |
| K | GLU11 | |
| B | GLU11 | |
| C | GLU11 | |
| D | GLU11 | |
| E | GLU11 | |
| F | GLU11 | |
| G | GLU11 | |
| I | GLU11 | |
| J | GLU11 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 10 |
| Details | CARBOHYD: O-linked (GalNAc...) serine; partial => ECO:0000269|PubMed:22576872, ECO:0000305|PubMed:21712440 |
| Chain | Residue | Details |
| A | GLN15 | |
| K | GLN15 | |
| B | GLN15 | |
| C | GLN15 | |
| D | GLN15 | |
| E | GLN15 | |
| F | GLN15 | |
| G | GLN15 | |
| I | GLN15 | |
| J | GLN15 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 10 |
| Details | CARBOHYD: O-linked (HexNAc...) tyrosine; partial => ECO:0000269|PubMed:22576872 |
| Chain | Residue | Details |
| A | GLY29 | |
| K | GLY29 | |
| B | GLY29 | |
| C | GLY29 | |
| D | GLY29 | |
| E | GLY29 | |
| F | GLY29 | |
| G | GLY29 | |
| I | GLY29 | |
| J | GLY29 |
