8FDG

Cryo-EM structure of coagulation factor V short

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005507	molecular_function	copper ion binding

Functional Information from PROSITE/UniProt

site_id	PS00079
Number of Residues	21
Details	MULTICOPPER_OXIDASE1 Multicopper oxidases signature 1. GkWiIsSlTPkhLqAGMqayI

Chain	Residue	Details
A	GLY276-ILE296
A	GLY1149-PHE1169

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site_id	PS01285
Number of Residues	34
Details	FA58C_1 Coagulation factors 5/8 type C domain (FA58C) signature 1. AWsveklaaefaskp..WIqVDmqkeviItgIqTQG

Chain	Residue	Details
A	ALA1216-GLY1249
A	ALA1380-GLY1409

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site_id	PS01286
Number of Residues	17
Details	FA58C_2 Coagulation factors 5/8 type C domain (FA58C) signature 2. Ptraynrpt..LRlELqGC

Chain	Residue	Details
A	PRO1314-CYS1330
A	PRO1474-CYS1490

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	ASP111
A	ASP112
A	HIS1112
A	HIS1114

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site_id	SWS_FT_FI2
Number of Residues	4
Details	SITE: Cleavage; by activated protein C => ECO:0000269|PubMed:7989361

Chain	Residue	Details
A	ARG306
A	ARG506
A	ARG679
A	CYS994

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site_id	SWS_FT_FI3
Number of Residues	3
Details	SITE: Cleavage; by thrombin => ECO:0000269|PubMed:3110773

Chain	Residue	Details
A	ARG709
A	LEU1018
A	ARG842

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19690332

Chain	Residue	Details
A	THR612

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site_id	SWS_FT_FI5
Number of Residues	7
Details	MOD_RES: Sulfotyrosine => ECO:0000255

Chain	Residue	Details
A	TYR665
A	TYR696
A	TYR698
A	TYR791
A	TYR807
A	TYR812
A	TYR862

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site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine; by FAM20C => ECO:0000269|PubMed:26091039

Chain	Residue	Details
A	ARG831

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site_id	SWS_FT_FI7
Number of Residues	21
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN23
A	ASN748
A	ASN754
A	LEU910
A	ASP1046
A	LYS1055
A	HIS1075
A	ASN1078
A	THR1451
A	ASN768
A	ASN972
A	ASN27
A	ASN1279
A	ASN1478
A	ASN211
A	ASN354
A	ASN440
A	ASN526
A	ASN713
A	ASN724
A	ASN732

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site_id	SWS_FT_FI8
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16263699, ECO:0000269|PubMed:16335952

Chain	Residue	Details
A	ASN269

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site_id	SWS_FT_FI9
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952

Chain	Residue	Details
A	ASN432
A	GLU793
A	SER949
A	ASN828

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