Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8F75

LRRC8A(T48D):C conformation 2 LRR focus

Functional Information from GO Data

Chain	GOid	namespace	contents
F	0005225	molecular_function	volume-sensitive anion channel activity
F	0005737	cellular_component	cytoplasm
F	0005783	cellular_component	endoplasmic reticulum
F	0005789	cellular_component	endoplasmic reticulum membrane
F	0005886	cellular_component	plasma membrane
F	0006811	biological_process	monoatomic ion transport
F	0015734	biological_process	taurine transmembrane transport
F	0015810	biological_process	aspartate transmembrane transport
F	0016020	cellular_component	membrane
F	0034214	biological_process	protein hexamerization
F	0034220	biological_process	monoatomic ion transmembrane transport
F	0034702	cellular_component	monoatomic ion channel complex
F	0045444	biological_process	fat cell differentiation
F	0055085	biological_process	transmembrane transport
F	0071470	biological_process	cellular response to osmotic stress
F	0098656	biological_process	monoatomic anion transmembrane transport
F	0140361	biological_process	cyclic-GMP-AMP transmembrane import across plasma membrane

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	22
Details	Repeat: {"description":"LRR 1","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	44
Details	Repeat: {"description":"LRR 2","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	42
Details	Repeat: {"description":"LRR 3","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	46
Details	Repeat: {"description":"LRR 4","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	44
Details	Repeat: {"description":"LRR 5","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	48
Details	Repeat: {"description":"LRR 6","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	44
Details	Repeat: {"description":"LRR 7","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	44
Details	Repeat: {"description":"LRR 8","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	46
Details	Repeat: {"description":"LRR 9","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	46
Details	Repeat: {"description":"LRR 10","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	44
Details	Repeat: {"description":"LRR 11","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	44
Details	Repeat: {"description":"LRR 12","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	42
Details	Repeat: {"description":"LRR 13","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	44
Details	Repeat: {"description":"LRR 14","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	42
Details	Repeat: {"description":"LRR 15","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	44
Details	Repeat: {"description":"LRR 16","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	46
Details	Repeat: {"description":"LRR 17","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29769723","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	2
Details	Motif: {"description":"Di-leucine motif","evidences":[{"source":"UniProtKB","id":"Q8IWT6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	11
Details	Repeat: {"description":"LRR 1","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8B40","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	22
Details	Repeat: {"description":"LRR 2","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8B40","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	20
Details	Repeat: {"description":"LRR 3","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8B40","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	21
Details	Repeat: {"description":"LRR 4","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8B40","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	23
Details	Repeat: {"description":"LRR 5","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8B40","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	22
Details	Repeat: {"description":"LRR 6","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8B40","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	22
Details	Repeat: {"description":"LRR 7","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8B40","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI26
Number of Residues	20
Details	Repeat: {"description":"LRR 8","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8B40","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI27
Number of Residues	23
Details	Repeat: {"description":"LRR 9","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8B40","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI28
Number of Residues	22
Details	Repeat: {"description":"LRR 10","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8B40","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI29
Number of Residues	22
Details	Repeat: {"description":"LRR 11","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8B40","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI30
Number of Residues	22
Details	Repeat: {"description":"LRR 12","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8B40","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI31
Number of Residues	21
Details	Repeat: {"description":"LRR 13","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8B40","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI32
Number of Residues	22
Details	Repeat: {"description":"LRR 14","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8B40","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI33
Number of Residues	21
Details	Repeat: {"description":"LRR 15","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8B40","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI34
Number of Residues	22
Details	Repeat: {"description":"LRR 16","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8B40","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI35
Number of Residues	23
Details	Repeat: {"description":"LRR 17","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8B40","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)