8F6K

Cryo-EM structure of a Zinc-loaded H263A/D287A mutant of the YiiP-Fab complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006812	biological_process	monoatomic cation transport
A	0006826	biological_process	iron ion transport
A	0006829	biological_process	zinc ion transport
A	0006882	biological_process	intracellular zinc ion homeostasis
A	0008324	molecular_function	monoatomic cation transmembrane transporter activity
A	0015086	molecular_function	cadmium ion transmembrane transporter activity
A	0015093	molecular_function	ferrous iron transmembrane transporter activity
A	0015341	molecular_function	zinc efflux antiporter activity
A	0016020	cellular_component	membrane
A	0034755	biological_process	iron ion transmembrane transport
A	0046872	molecular_function	metal ion binding
A	0055085	biological_process	transmembrane transport
A	0070574	biological_process	cadmium ion transmembrane transport
A	0071577	biological_process	zinc ion transmembrane transport
A	0098655	biological_process	monoatomic cation transmembrane transport
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006812	biological_process	monoatomic cation transport
B	0006826	biological_process	iron ion transport
B	0006829	biological_process	zinc ion transport
B	0006882	biological_process	intracellular zinc ion homeostasis
B	0008324	molecular_function	monoatomic cation transmembrane transporter activity
B	0015086	molecular_function	cadmium ion transmembrane transporter activity
B	0015093	molecular_function	ferrous iron transmembrane transporter activity
B	0015341	molecular_function	zinc efflux antiporter activity
B	0016020	cellular_component	membrane
B	0034755	biological_process	iron ion transmembrane transport
B	0046872	molecular_function	metal ion binding
B	0055085	biological_process	transmembrane transport
B	0070574	biological_process	cadmium ion transmembrane transport
B	0071577	biological_process	zinc ion transmembrane transport
B	0098655	biological_process	monoatomic cation transmembrane transport
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006812	biological_process	monoatomic cation transport
C	0006826	biological_process	iron ion transport
C	0006829	biological_process	zinc ion transport
C	0006882	biological_process	intracellular zinc ion homeostasis
C	0008324	molecular_function	monoatomic cation transmembrane transporter activity
C	0015086	molecular_function	cadmium ion transmembrane transporter activity
C	0015093	molecular_function	ferrous iron transmembrane transporter activity
C	0015341	molecular_function	zinc efflux antiporter activity
C	0016020	cellular_component	membrane
C	0034755	biological_process	iron ion transmembrane transport
C	0046872	molecular_function	metal ion binding
C	0055085	biological_process	transmembrane transport
C	0070574	biological_process	cadmium ion transmembrane transport
C	0071577	biological_process	zinc ion transmembrane transport
C	0098655	biological_process	monoatomic cation transmembrane transport
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0006812	biological_process	monoatomic cation transport
D	0006826	biological_process	iron ion transport
D	0006829	biological_process	zinc ion transport
D	0006882	biological_process	intracellular zinc ion homeostasis
D	0008324	molecular_function	monoatomic cation transmembrane transporter activity
D	0015086	molecular_function	cadmium ion transmembrane transporter activity
D	0015093	molecular_function	ferrous iron transmembrane transporter activity
D	0015341	molecular_function	zinc efflux antiporter activity
D	0016020	cellular_component	membrane
D	0034755	biological_process	iron ion transmembrane transport
D	0046872	molecular_function	metal ion binding
D	0055085	biological_process	transmembrane transport
D	0070574	biological_process	cadmium ion transmembrane transport
D	0071577	biological_process	zinc ion transmembrane transport
D	0098655	biological_process	monoatomic cation transmembrane transport

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	404
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"UniProtKB","id":"P69380","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	168
Details	Topological domain: {"description":"Periplasmic","evidences":[{"source":"UniProtKB","id":"P69380","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	112
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"UniProtKB","id":"P69380","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29507252","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34254979","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"NOV-2022","submissionDatabase":"PDB data bank","title":"Characterization of individual Zn2+ binding sites of YiiP.","authors":["Lopez-Redondo M.L.","Hussein A.K.","Stokes D.L."]}},{"source":"PDB","id":"5VRF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7KZZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6K","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29507252","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34254979","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"NOV-2022","submissionDatabase":"PDB data bank","title":"Characterization of individual Zn2+ binding sites of YiiP.","authors":["Lopez-Redondo M.L.","Hussein A.K.","Stokes D.L."]}},{"source":"PDB","id":"5VRF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7KZZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6J","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29507252","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34254979","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"NOV-2022","submissionDatabase":"PDB data bank","title":"Characterization of individual Zn2+ binding sites of YiiP.","authors":["Lopez-Redondo M.L.","Hussein A.K.","Stokes D.L."]}},{"source":"PDB","id":"5VRF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7KZZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6J","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29507252","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34254979","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"NOV-2022","submissionDatabase":"PDB data bank","title":"Characterization of individual Zn2+ binding sites of YiiP.","authors":["Lopez-Redondo M.L.","Hussein A.K.","Stokes D.L."]}},{"source":"PDB","id":"5VRF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7KZZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6J","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29507252","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34254979","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"NOV-2022","submissionDatabase":"PDB data bank","title":"Characterization of individual Zn2+ binding sites of YiiP.","authors":["Lopez-Redondo M.L.","Hussein A.K.","Stokes D.L."]}},{"source":"PDB","id":"5VRF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7KZZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6K","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29507252","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34254979","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"NOV-2022","submissionDatabase":"PDB data bank","title":"Characterization of individual Zn2+ binding sites of YiiP.","authors":["Lopez-Redondo M.L.","Hussein A.K.","Stokes D.L."]}},{"source":"PDB","id":"5VRF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7KZZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6H","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29507252","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34254979","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5VRF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7KZZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29507252","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34254979","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"NOV-2022","submissionDatabase":"PDB data bank","title":"Characterization of individual Zn2+ binding sites of YiiP.","authors":["Lopez-Redondo M.L.","Hussein A.K.","Stokes D.L."]}},{"source":"PDB","id":"5VRF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7KZZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6J","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29507252","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34254979","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"NOV-2022","submissionDatabase":"PDB data bank","title":"Characterization of individual Zn2+ binding sites of YiiP.","authors":["Lopez-Redondo M.L.","Hussein A.K.","Stokes D.L."]}},{"source":"PDB","id":"5VRF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7KZZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6J","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29507252","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34254979","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"NOV-2022","submissionDatabase":"PDB data bank","title":"Characterization of individual Zn2+ binding sites of YiiP.","authors":["Lopez-Redondo M.L.","Hussein A.K.","Stokes D.L."]}},{"source":"PDB","id":"5VRF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7KZZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6I","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---