Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8F6K

Cryo-EM structure of a Zinc-loaded H263A/D287A mutant of the YiiP-Fab complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0006812	biological_process	monoatomic cation transport
A	0006826	biological_process	iron ion transport
A	0006829	biological_process	zinc ion transport
A	0006882	biological_process	intracellular zinc ion homeostasis
A	0008324	molecular_function	monoatomic cation transmembrane transporter activity
A	0015086	molecular_function	cadmium ion transmembrane transporter activity
A	0015093	molecular_function	ferrous iron transmembrane transporter activity
A	0015341	molecular_function	zinc efflux active transmembrane transporter activity
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0034755	biological_process	iron ion transmembrane transport
A	0046872	molecular_function	metal ion binding
A	0055085	biological_process	transmembrane transport
A	0070574	biological_process	cadmium ion transmembrane transport
A	0071577	biological_process	zinc ion transmembrane transport
A	0098655	biological_process	monoatomic cation transmembrane transport
B	0005886	cellular_component	plasma membrane
B	0006812	biological_process	monoatomic cation transport
B	0006826	biological_process	iron ion transport
B	0006829	biological_process	zinc ion transport
B	0006882	biological_process	intracellular zinc ion homeostasis
B	0008324	molecular_function	monoatomic cation transmembrane transporter activity
B	0015086	molecular_function	cadmium ion transmembrane transporter activity
B	0015093	molecular_function	ferrous iron transmembrane transporter activity
B	0015341	molecular_function	zinc efflux active transmembrane transporter activity
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0034755	biological_process	iron ion transmembrane transport
B	0046872	molecular_function	metal ion binding
B	0055085	biological_process	transmembrane transport
B	0070574	biological_process	cadmium ion transmembrane transport
B	0071577	biological_process	zinc ion transmembrane transport
B	0098655	biological_process	monoatomic cation transmembrane transport
C	0005886	cellular_component	plasma membrane
C	0006812	biological_process	monoatomic cation transport
C	0006826	biological_process	iron ion transport
C	0006829	biological_process	zinc ion transport
C	0006882	biological_process	intracellular zinc ion homeostasis
C	0008324	molecular_function	monoatomic cation transmembrane transporter activity
C	0015086	molecular_function	cadmium ion transmembrane transporter activity
C	0015093	molecular_function	ferrous iron transmembrane transporter activity
C	0015341	molecular_function	zinc efflux active transmembrane transporter activity
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0034755	biological_process	iron ion transmembrane transport
C	0046872	molecular_function	metal ion binding
C	0055085	biological_process	transmembrane transport
C	0070574	biological_process	cadmium ion transmembrane transport
C	0071577	biological_process	zinc ion transmembrane transport
C	0098655	biological_process	monoatomic cation transmembrane transport
D	0005886	cellular_component	plasma membrane
D	0006812	biological_process	monoatomic cation transport
D	0006826	biological_process	iron ion transport
D	0006829	biological_process	zinc ion transport
D	0006882	biological_process	intracellular zinc ion homeostasis
D	0008324	molecular_function	monoatomic cation transmembrane transporter activity
D	0015086	molecular_function	cadmium ion transmembrane transporter activity
D	0015093	molecular_function	ferrous iron transmembrane transporter activity
D	0015341	molecular_function	zinc efflux active transmembrane transporter activity
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0034755	biological_process	iron ion transmembrane transport
D	0046872	molecular_function	metal ion binding
D	0055085	biological_process	transmembrane transport
D	0070574	biological_process	cadmium ion transmembrane transport
D	0071577	biological_process	zinc ion transmembrane transport
D	0098655	biological_process	monoatomic cation transmembrane transport

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	560
Details	TOPO_DOM: Cytoplasmic => ECO:0000250\|UniProtKB:P69380

Chain	Residue	Details
A	MET1-SER18
C	ALA61-LEU83
C	ARG139-ASN145
C	TYR201-GLN296
D	MET1-SER18
D	ALA61-LEU83
D	ARG139-ASN145
D	TYR201-GLN296
A	ALA61-LEU83
A	ARG139-ASN145
A	TYR201-GLN296
B	MET1-SER18
B	ALA61-LEU83
B	ARG139-ASN145
B	TYR201-GLN296
C	MET1-SER18

site_id	SWS_FT_FI2
Number of Residues	404
Details	TRANSMEM: Helical => ECO:0000250\|UniProtKB:P69380

Chain	Residue	Details
A	VAL19-ALA32
B	VAL120-LYS138
B	SER146-LEU160
B	ASP181-GLY200
C	VAL19-ALA32
C	SER44-ILE60
C	ALA84-GLU105
C	VAL120-LYS138
C	SER146-LEU160
C	ASP181-GLY200
D	VAL19-ALA32
A	SER44-ILE60
D	SER44-ILE60
D	ALA84-GLU105
D	VAL120-LYS138
D	SER146-LEU160
D	ASP181-GLY200
A	ALA84-GLU105
A	VAL120-LYS138
A	SER146-LEU160
A	ASP181-GLY200
B	VAL19-ALA32
B	SER44-ILE60
B	ALA84-GLU105

site_id	SWS_FT_FI3
Number of Residues	168
Details	TOPO_DOM: Periplasmic => ECO:0000250\|UniProtKB:P69380

Chain	Residue	Details
A	TRP33-ALA43
D	TRP33-ALA43
D	ARG106-GLY119
D	PHE161-ALA180
A	ARG106-GLY119
A	PHE161-ALA180
B	TRP33-ALA43
B	ARG106-GLY119
B	PHE161-ALA180
C	TRP33-ALA43
C	ARG106-GLY119
C	PHE161-ALA180

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:29507252, ECO:0000269\|PubMed:34254979, ECO:0000269\|Ref.5, ECO:0007744\|PDB:5VRF, ECO:0007744\|PDB:7KZZ, ECO:0007744\|PDB:8F6E, ECO:0007744\|PDB:8F6H, ECO:0007744\|PDB:8F6I, ECO:0007744\|PDB:8F6J, ECO:0007744\|PDB:8F6K

Chain	Residue	Details
A	ASP47
B	ASP47
C	ASP47
D	ASP47

site_id	SWS_FT_FI5
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:29507252, ECO:0000269\|PubMed:34254979, ECO:0000269\|Ref.5, ECO:0007744\|PDB:5VRF, ECO:0007744\|PDB:7KZZ, ECO:0007744\|PDB:8F6E, ECO:0007744\|PDB:8F6H, ECO:0007744\|PDB:8F6I, ECO:0007744\|PDB:8F6J

Chain	Residue	Details
A	ASP51
B	ASP51
C	ASP51
D	ASP51

site_id	SWS_FT_FI6
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269\|PubMed:29507252, ECO:0000269\|PubMed:34254979, ECO:0000269\|Ref.5, ECO:0007744\|PDB:5VRF, ECO:0007744\|PDB:7KZZ, ECO:0007744\|PDB:8F6E, ECO:0007744\|PDB:8F6F, ECO:0007744\|PDB:8F6J

Chain	Residue	Details
A	ASP70
A	HIS73
B	ASP70
B	HIS73
C	ASP70
C	HIS73
D	ASP70
D	HIS73

site_id	SWS_FT_FI7
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:29507252, ECO:0000269\|PubMed:34254979, ECO:0000269\|Ref.5, ECO:0007744\|PDB:5VRF, ECO:0007744\|PDB:7KZZ, ECO:0007744\|PDB:8F6E, ECO:0007744\|PDB:8F6J

Chain	Residue	Details
A	HIS77
B	HIS77
C	HIS77
D	HIS77

site_id	SWS_FT_FI8
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269\|PubMed:29507252, ECO:0000269\|PubMed:34254979, ECO:0000269\|Ref.5, ECO:0007744\|PDB:5VRF, ECO:0007744\|PDB:7KZZ, ECO:0007744\|PDB:8F6E, ECO:0007744\|PDB:8F6H, ECO:0007744\|PDB:8F6I, ECO:0007744\|PDB:8F6K

Chain	Residue	Details
A	HIS155
A	ASP159
B	HIS155
B	ASP159
C	HIS155
C	ASP159
D	HIS155
D	ASP159

site_id	SWS_FT_FI9
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:29507252, ECO:0000269\|PubMed:34254979, ECO:0000269\|Ref.5, ECO:0007744\|PDB:5VRF, ECO:0007744\|PDB:7KZZ, ECO:0007744\|PDB:8F6H

Chain	Residue	Details
A	HIS234
B	HIS234
C	HIS234
D	HIS234

site_id	SWS_FT_FI10
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:29507252, ECO:0000269\|PubMed:34254979, ECO:0007744\|PDB:5VRF, ECO:0007744\|PDB:7KZZ

Chain	Residue	Details
A	ASP235
B	ASP235
C	ASP235
D	ASP235

site_id	SWS_FT_FI11
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:29507252, ECO:0000269\|PubMed:34254979, ECO:0000269\|Ref.5, ECO:0007744\|PDB:5VRF, ECO:0007744\|PDB:7KZZ, ECO:0007744\|PDB:8F6F, ECO:0007744\|PDB:8F6H, ECO:0007744\|PDB:8F6I, ECO:0007744\|PDB:8F6J

Chain	Residue	Details
A	HIS250
B	HIS250
C	HIS250
D	HIS250

site_id	SWS_FT_FI12
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269\|PubMed:29507252, ECO:0000269\|PubMed:34254979, ECO:0000269\|Ref.5, ECO:0007744\|PDB:5VRF, ECO:0007744\|PDB:7KZZ, ECO:0007744\|PDB:8F6E, ECO:0007744\|PDB:8F6F, ECO:0007744\|PDB:8F6H, ECO:0007744\|PDB:8F6I, ECO:0007744\|PDB:8F6J

Chain	Residue	Details
A	ALA263
A	HIS285
B	ALA263
B	HIS285
C	ALA263
C	HIS285
D	ALA263
D	HIS285

site_id	SWS_FT_FI13
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:29507252, ECO:0000269\|PubMed:34254979, ECO:0000269\|Ref.5, ECO:0007744\|PDB:5VRF, ECO:0007744\|PDB:7KZZ, ECO:0007744\|PDB:8F6E, ECO:0007744\|PDB:8F6F, ECO:0007744\|PDB:8F6H, ECO:0007744\|PDB:8F6I

Chain	Residue	Details
A	ALA287
B	ALA287
C	ALA287
D	ALA287

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)