8F6I
Cryo-EM structure of a Zinc-loaded symmetrical D70A mutant of the YiiP-Fab complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006812 | biological_process | monoatomic cation transport |
| A | 0006826 | biological_process | iron ion transport |
| A | 0006829 | biological_process | zinc ion transport |
| A | 0006882 | biological_process | intracellular zinc ion homeostasis |
| A | 0008324 | molecular_function | monoatomic cation transmembrane transporter activity |
| A | 0015086 | molecular_function | cadmium ion transmembrane transporter activity |
| A | 0015093 | molecular_function | ferrous iron transmembrane transporter activity |
| A | 0015341 | molecular_function | zinc efflux active transmembrane transporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0034755 | biological_process | iron ion transmembrane transport |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0070574 | biological_process | cadmium ion transmembrane transport |
| A | 0071577 | biological_process | zinc ion transmembrane transport |
| A | 0098655 | biological_process | monoatomic cation transmembrane transport |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006812 | biological_process | monoatomic cation transport |
| B | 0006826 | biological_process | iron ion transport |
| B | 0006829 | biological_process | zinc ion transport |
| B | 0006882 | biological_process | intracellular zinc ion homeostasis |
| B | 0008324 | molecular_function | monoatomic cation transmembrane transporter activity |
| B | 0015086 | molecular_function | cadmium ion transmembrane transporter activity |
| B | 0015093 | molecular_function | ferrous iron transmembrane transporter activity |
| B | 0015341 | molecular_function | zinc efflux active transmembrane transporter activity |
| B | 0016020 | cellular_component | membrane |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0034755 | biological_process | iron ion transmembrane transport |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0070574 | biological_process | cadmium ion transmembrane transport |
| B | 0071577 | biological_process | zinc ion transmembrane transport |
| B | 0098655 | biological_process | monoatomic cation transmembrane transport |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH |
| Chain | Residue | Details |
| F | TYR211-HIS217 | |
| E | TYR194-HIS200 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 280 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:P69380 |
| Chain | Residue | Details |
| B | MET1-SER18 | |
| B | ALA61-LEU83 | |
| B | ARG139-ASN145 | |
| B | TYR201-GLN296 | |
| A | MET1-SER18 | |
| A | ALA61-LEU83 | |
| A | ARG139-ASN145 | |
| A | TYR201-GLN296 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 202 |
| Details | TRANSMEM: Helical => ECO:0000250|UniProtKB:P69380 |
| Chain | Residue | Details |
| B | VAL19-ALA32 | |
| A | VAL120-LYS138 | |
| A | SER146-LEU160 | |
| A | ASP181-GLY200 | |
| B | SER44-ILE60 | |
| B | ALA84-GLU105 | |
| B | VAL120-LYS138 | |
| B | SER146-LEU160 | |
| B | ASP181-GLY200 | |
| A | VAL19-ALA32 | |
| A | SER44-ILE60 | |
| A | ALA84-GLU105 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 84 |
| Details | TOPO_DOM: Periplasmic => ECO:0000250|UniProtKB:P69380 |
| Chain | Residue | Details |
| B | TRP33-ALA43 | |
| B | ARG106-GLY119 | |
| B | PHE161-ALA180 | |
| A | TRP33-ALA43 | |
| A | ARG106-GLY119 | |
| A | PHE161-ALA180 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:29507252, ECO:0000269|PubMed:34254979, ECO:0000269|Ref.5, ECO:0007744|PDB:5VRF, ECO:0007744|PDB:7KZZ, ECO:0007744|PDB:8F6E, ECO:0007744|PDB:8F6H, ECO:0007744|PDB:8F6I, ECO:0007744|PDB:8F6J, ECO:0007744|PDB:8F6K |
| Chain | Residue | Details |
| B | ASP47 | |
| A | ASP47 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:29507252, ECO:0000269|PubMed:34254979, ECO:0000269|Ref.5, ECO:0007744|PDB:5VRF, ECO:0007744|PDB:7KZZ, ECO:0007744|PDB:8F6E, ECO:0007744|PDB:8F6H, ECO:0007744|PDB:8F6I, ECO:0007744|PDB:8F6J |
| Chain | Residue | Details |
| B | ASP51 | |
| A | ASP51 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:29507252, ECO:0000269|PubMed:34254979, ECO:0000269|Ref.5, ECO:0007744|PDB:5VRF, ECO:0007744|PDB:7KZZ, ECO:0007744|PDB:8F6E, ECO:0007744|PDB:8F6F, ECO:0007744|PDB:8F6J |
| Chain | Residue | Details |
| B | ALA70 | |
| B | HIS73 | |
| A | ALA70 | |
| A | HIS73 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:29507252, ECO:0000269|PubMed:34254979, ECO:0000269|Ref.5, ECO:0007744|PDB:5VRF, ECO:0007744|PDB:7KZZ, ECO:0007744|PDB:8F6E, ECO:0007744|PDB:8F6J |
| Chain | Residue | Details |
| B | HIS77 | |
| A | HIS77 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:29507252, ECO:0000269|PubMed:34254979, ECO:0000269|Ref.5, ECO:0007744|PDB:5VRF, ECO:0007744|PDB:7KZZ, ECO:0007744|PDB:8F6E, ECO:0007744|PDB:8F6H, ECO:0007744|PDB:8F6I, ECO:0007744|PDB:8F6K |
| Chain | Residue | Details |
| B | HIS155 | |
| B | ASP159 | |
| A | HIS155 | |
| A | ASP159 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:29507252, ECO:0000269|PubMed:34254979, ECO:0000269|Ref.5, ECO:0007744|PDB:5VRF, ECO:0007744|PDB:7KZZ, ECO:0007744|PDB:8F6H |
| Chain | Residue | Details |
| B | HIS234 | |
| A | HIS234 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:29507252, ECO:0000269|PubMed:34254979, ECO:0007744|PDB:5VRF, ECO:0007744|PDB:7KZZ |
| Chain | Residue | Details |
| B | ASP235 | |
| A | ASP235 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:29507252, ECO:0000269|PubMed:34254979, ECO:0000269|Ref.5, ECO:0007744|PDB:5VRF, ECO:0007744|PDB:7KZZ, ECO:0007744|PDB:8F6F, ECO:0007744|PDB:8F6H, ECO:0007744|PDB:8F6I, ECO:0007744|PDB:8F6J |
| Chain | Residue | Details |
| B | HIS250 | |
| A | HIS250 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:29507252, ECO:0000269|PubMed:34254979, ECO:0000269|Ref.5, ECO:0007744|PDB:5VRF, ECO:0007744|PDB:7KZZ, ECO:0007744|PDB:8F6E, ECO:0007744|PDB:8F6F, ECO:0007744|PDB:8F6H, ECO:0007744|PDB:8F6I, ECO:0007744|PDB:8F6J |
| Chain | Residue | Details |
| B | HIS263 | |
| B | HIS285 | |
| A | HIS263 | |
| A | HIS285 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:29507252, ECO:0000269|PubMed:34254979, ECO:0000269|Ref.5, ECO:0007744|PDB:5VRF, ECO:0007744|PDB:7KZZ, ECO:0007744|PDB:8F6E, ECO:0007744|PDB:8F6F, ECO:0007744|PDB:8F6H, ECO:0007744|PDB:8F6I |
| Chain | Residue | Details |
| B | ASP287 | |
| A | ASP287 |
