8F6H
Cryo-EM structure of a Zinc-loaded asymmetrical TMD D70A mutant of the YiiP-Fab complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006812 | biological_process | monoatomic cation transport |
| A | 0006826 | biological_process | iron ion transport |
| A | 0006829 | biological_process | zinc ion transport |
| A | 0006882 | biological_process | intracellular zinc ion homeostasis |
| A | 0008324 | molecular_function | monoatomic cation transmembrane transporter activity |
| A | 0015086 | molecular_function | cadmium ion transmembrane transporter activity |
| A | 0015093 | molecular_function | ferrous iron transmembrane transporter activity |
| A | 0015341 | molecular_function | zinc efflux antiporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0034755 | biological_process | iron ion transmembrane transport |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0070574 | biological_process | cadmium ion transmembrane transport |
| A | 0071577 | biological_process | zinc ion transmembrane transport |
| A | 0098655 | biological_process | monoatomic cation transmembrane transport |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0006812 | biological_process | monoatomic cation transport |
| B | 0006826 | biological_process | iron ion transport |
| B | 0006829 | biological_process | zinc ion transport |
| B | 0006882 | biological_process | intracellular zinc ion homeostasis |
| B | 0008324 | molecular_function | monoatomic cation transmembrane transporter activity |
| B | 0015086 | molecular_function | cadmium ion transmembrane transporter activity |
| B | 0015093 | molecular_function | ferrous iron transmembrane transporter activity |
| B | 0015341 | molecular_function | zinc efflux antiporter activity |
| B | 0016020 | cellular_component | membrane |
| B | 0034755 | biological_process | iron ion transmembrane transport |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0070574 | biological_process | cadmium ion transmembrane transport |
| B | 0071577 | biological_process | zinc ion transmembrane transport |
| B | 0098655 | biological_process | monoatomic cation transmembrane transport |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH |
| Chain | Residue | Details |
| C | TYR194-HIS200 | |
| D | TYR211-HIS217 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 202 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"UniProtKB","id":"P69380","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 84 |
| Details | Topological domain: {"description":"Periplasmic","evidences":[{"source":"UniProtKB","id":"P69380","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 34 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"UniProtKB","id":"P69380","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"29507252","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34254979","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"NOV-2022","submissionDatabase":"PDB data bank","title":"Characterization of individual Zn2+ binding sites of YiiP.","authors":["Lopez-Redondo M.L.","Hussein A.K.","Stokes D.L."]}},{"source":"PDB","id":"5VRF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7KZZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6K","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"29507252","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34254979","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"NOV-2022","submissionDatabase":"PDB data bank","title":"Characterization of individual Zn2+ binding sites of YiiP.","authors":["Lopez-Redondo M.L.","Hussein A.K.","Stokes D.L."]}},{"source":"PDB","id":"5VRF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7KZZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6J","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"29507252","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34254979","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"NOV-2022","submissionDatabase":"PDB data bank","title":"Characterization of individual Zn2+ binding sites of YiiP.","authors":["Lopez-Redondo M.L.","Hussein A.K.","Stokes D.L."]}},{"source":"PDB","id":"5VRF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7KZZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6J","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"29507252","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34254979","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"NOV-2022","submissionDatabase":"PDB data bank","title":"Characterization of individual Zn2+ binding sites of YiiP.","authors":["Lopez-Redondo M.L.","Hussein A.K.","Stokes D.L."]}},{"source":"PDB","id":"5VRF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7KZZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6J","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"29507252","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34254979","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"NOV-2022","submissionDatabase":"PDB data bank","title":"Characterization of individual Zn2+ binding sites of YiiP.","authors":["Lopez-Redondo M.L.","Hussein A.K.","Stokes D.L."]}},{"source":"PDB","id":"5VRF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7KZZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6K","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"29507252","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34254979","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"NOV-2022","submissionDatabase":"PDB data bank","title":"Characterization of individual Zn2+ binding sites of YiiP.","authors":["Lopez-Redondo M.L.","Hussein A.K.","Stokes D.L."]}},{"source":"PDB","id":"5VRF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7KZZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6H","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"29507252","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34254979","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5VRF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7KZZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"29507252","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34254979","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"NOV-2022","submissionDatabase":"PDB data bank","title":"Characterization of individual Zn2+ binding sites of YiiP.","authors":["Lopez-Redondo M.L.","Hussein A.K.","Stokes D.L."]}},{"source":"PDB","id":"5VRF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7KZZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6J","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"29507252","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34254979","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"NOV-2022","submissionDatabase":"PDB data bank","title":"Characterization of individual Zn2+ binding sites of YiiP.","authors":["Lopez-Redondo M.L.","Hussein A.K.","Stokes D.L."]}},{"source":"PDB","id":"5VRF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7KZZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6J","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"29507252","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34254979","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"NOV-2022","submissionDatabase":"PDB data bank","title":"Characterization of individual Zn2+ binding sites of YiiP.","authors":["Lopez-Redondo M.L.","Hussein A.K.","Stokes D.L."]}},{"source":"PDB","id":"5VRF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7KZZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F6I","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
