8F5F

human branched chain ketoacid dehydrogenase kinase in complex with inhibitors

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0004722	molecular_function	protein serine/threonine phosphatase activity
A	0004740	molecular_function	pyruvate dehydrogenase (acetyl-transferring) kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0006550	biological_process	L-isoleucine catabolic process
A	0006552	biological_process	L-leucine catabolic process
A	0006574	biological_process	L-valine catabolic process
A	0007283	biological_process	spermatogenesis
A	0008610	biological_process	lipid biosynthetic process
A	0009063	biological_process	amino acid catabolic process
A	0009083	biological_process	branched-chain amino acid catabolic process
A	0010510	biological_process	regulation of pyruvate decarboxylation to acetyl-CoA
A	0010906	biological_process	regulation of glucose metabolic process
A	0016301	molecular_function	kinase activity
A	0016310	biological_process	phosphorylation
A	0016740	molecular_function	transferase activity
A	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
A	0045252	cellular_component	oxoglutarate dehydrogenase complex
A	0047323	molecular_function	[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity
A	0106310	molecular_function	protein serine kinase activity
A	0140096	molecular_function	catalytic activity, acting on a protein
B	0000166	molecular_function	nucleotide binding
B	0004672	molecular_function	protein kinase activity
B	0004674	molecular_function	protein serine/threonine kinase activity
B	0004722	molecular_function	protein serine/threonine phosphatase activity
B	0004740	molecular_function	pyruvate dehydrogenase (acetyl-transferring) kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0006550	biological_process	L-isoleucine catabolic process
B	0006552	biological_process	L-leucine catabolic process
B	0006574	biological_process	L-valine catabolic process
B	0007283	biological_process	spermatogenesis
B	0008610	biological_process	lipid biosynthetic process
B	0009063	biological_process	amino acid catabolic process
B	0009083	biological_process	branched-chain amino acid catabolic process
B	0010510	biological_process	regulation of pyruvate decarboxylation to acetyl-CoA
B	0010906	biological_process	regulation of glucose metabolic process
B	0016301	molecular_function	kinase activity
B	0016310	biological_process	phosphorylation
B	0016740	molecular_function	transferase activity
B	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
B	0045252	cellular_component	oxoglutarate dehydrogenase complex
B	0047323	molecular_function	[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity
B	0106310	molecular_function	protein serine kinase activity
B	0140096	molecular_function	catalytic activity, acting on a protein

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"37558654","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8F5J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F5S","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PubMed","id":"37558654","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8F5J","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by autocatalysis","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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