8F5F

human branched chain ketoacid dehydrogenase kinase in complex with inhibitors

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0004722	molecular_function	protein serine/threonine phosphatase activity
A	0004740	molecular_function	pyruvate dehydrogenase (acetyl-transferring) kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0008610	biological_process	lipid biosynthetic process
A	0009063	biological_process	amino acid catabolic process
A	0009083	biological_process	branched-chain amino acid catabolic process
A	0010906	biological_process	regulation of glucose metabolic process
A	0016301	molecular_function	kinase activity
A	0016310	biological_process	phosphorylation
A	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
A	0045252	cellular_component	oxoglutarate dehydrogenase complex
A	0045763	biological_process	negative regulation of cellular amino acid metabolic process
A	0047323	molecular_function	[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity
A	0106310	molecular_function	protein serine kinase activity
B	0004672	molecular_function	protein kinase activity
B	0004674	molecular_function	protein serine/threonine kinase activity
B	0004722	molecular_function	protein serine/threonine phosphatase activity
B	0004740	molecular_function	pyruvate dehydrogenase (acetyl-transferring) kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0008610	biological_process	lipid biosynthetic process
B	0009063	biological_process	amino acid catabolic process
B	0009083	biological_process	branched-chain amino acid catabolic process
B	0010906	biological_process	regulation of glucose metabolic process
B	0016301	molecular_function	kinase activity
B	0016310	biological_process	phosphorylation
B	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
B	0045252	cellular_component	oxoglutarate dehydrogenase complex
B	0045763	biological_process	negative regulation of cellular amino acid metabolic process
B	0047323	molecular_function	[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity
B	0106310	molecular_function	protein serine kinase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	BINDING: BINDING => ECO:0000269|PubMed:37558654, ECO:0007744|PDB:8F5J, ECO:0007744|PDB:8F5S

Chain	Residue	Details
A	ASN249
B	GLY337
A	VAL298
A	ASP300
A	PHE303
A	GLY337
B	ASN249
B	VAL298
B	ASP300
B	PHE303

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site_id	SWS_FT_FI2
Number of Residues	10
Details	BINDING: BINDING => ECO:0000269|PubMed:37558654, ECO:0007744|PDB:8F5J

Chain	Residue	Details
A	ASP285
B	LEU340
A	THR304
A	THR305
A	HIS334
A	LEU340
B	ASP285
B	THR304
B	THR305
B	HIS334

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site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q00972

Chain	Residue	Details
A	SER1
A	SER330
B	SER1
B	SER330

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site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine; by autocatalysis => ECO:0000250

Chain	Residue	Details
A	SER22
B	SER22

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site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	LYS162
A	LYS203
B	LYS162
B	LYS203

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site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O55028

Chain	Residue	Details
A	SER326
B	SER326

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