8F5B
Human ABCA4 structure in complex with AMP-PNP
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0001523 | biological_process | retinoid metabolic process |
A | 0001750 | cellular_component | photoreceptor outer segment |
A | 0003924 | molecular_function | GTPase activity |
A | 0005501 | molecular_function | retinoid binding |
A | 0005502 | molecular_function | 11-cis retinal binding |
A | 0005503 | molecular_function | all-trans retinal binding |
A | 0005524 | molecular_function | ATP binding |
A | 0005548 | molecular_function | phospholipid transporter activity |
A | 0005783 | cellular_component | endoplasmic reticulum |
A | 0005886 | cellular_component | plasma membrane |
A | 0006649 | biological_process | phospholipid transfer to membrane |
A | 0006869 | biological_process | lipid transport |
A | 0007601 | biological_process | visual perception |
A | 0007603 | biological_process | phototransduction, visible light |
A | 0015850 | biological_process | organic hydroxy compound transport |
A | 0016020 | cellular_component | membrane |
A | 0016787 | molecular_function | hydrolase activity |
A | 0016887 | molecular_function | ATP hydrolysis activity |
A | 0031410 | cellular_component | cytoplasmic vesicle |
A | 0034632 | molecular_function | retinol transmembrane transporter activity |
A | 0034633 | biological_process | retinol transport |
A | 0042574 | biological_process | retinal metabolic process |
A | 0042626 | molecular_function | ATPase-coupled transmembrane transporter activity |
A | 0042995 | cellular_component | cell projection |
A | 0045332 | biological_process | phospholipid translocation |
A | 0045494 | biological_process | photoreceptor cell maintenance |
A | 0055085 | biological_process | transmembrane transport |
A | 0090555 | molecular_function | phosphatidylethanolamine flippase activity |
A | 0097381 | cellular_component | photoreceptor disc membrane |
A | 0120202 | cellular_component | rod photoreceptor disc membrane |
A | 0140326 | molecular_function | ATPase-coupled intramembrane lipid transporter activity |
A | 0140327 | molecular_function | flippase activity |
A | 0140347 | molecular_function | N-retinylidene-phosphatidylethanolamine flippase activity |
A | 0140359 | molecular_function | ABC-type transporter activity |
Functional Information from PROSITE/UniProt
site_id | PS00211 |
Number of Residues | 15 |
Details | ABC_TRANSPORTER_1 ABC transporters family signature. LSGGMQRKLSVAIAF |
Chain | Residue | Details |
A | LEU1062-PHE1076 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 240 |
Details | Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI2 |
Number of Residues | 65 |
Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI3 |
Number of Residues | 74 |
Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI4 |
Number of Residues | 231 |
Details | Domain: {"description":"ABC transporter 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI5 |
Number of Residues | 232 |
Details | Domain: {"description":"ABC transporter 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI6 |
Number of Residues | 5 |
Details | Region: {"description":"Essential for ATP binding and ATPase activity","evidences":[{"source":"PubMed","id":"31481235","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | Binding site: {"evidences":[{"source":"PubMed","id":"34625547","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7M1Q","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI8 |
Number of Residues | 8 |
Details | Binding site: {"evidences":[{"source":"PubMed","id":"33605212","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39128720","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7LKZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F5B","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI9 |
Number of Residues | 2 |
Details | Binding site: {"evidences":[{"source":"PubMed","id":"33605212","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39128720","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7LKZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8F5B","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI10 |
Number of Residues | 6 |
Details | Binding site: {"evidences":[{"source":"PubMed","id":"33605212","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7LKZ","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI11 |
Number of Residues | 6 |
Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11320094","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33605212","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34625547","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7LKP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7LKZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M1P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M1Q","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI12 |
Number of Residues | 1 |
Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11320094","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33605212","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34625547","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7LKP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M1P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M1Q","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |