8F4N
Dimer of aminoglycoside efflux pump AcrD
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0009636 | biological_process | response to toxic substance |
| A | 0015125 | molecular_function | bile acid transmembrane transporter activity |
| A | 0015562 | molecular_function | efflux transmembrane transporter activity |
| A | 0015721 | biological_process | bile acid and bile salt transport |
| A | 0016020 | cellular_component | membrane |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0042908 | biological_process | xenobiotic transport |
| A | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| A | 0046677 | biological_process | response to antibiotic |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0098567 | cellular_component | periplasmic side of plasma membrane |
| A | 0140330 | biological_process | xenobiotic detoxification by transmembrane export across the cell outer membrane |
| A | 1990281 | cellular_component | efflux pump complex |
| B | 0005515 | molecular_function | protein binding |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0009636 | biological_process | response to toxic substance |
| B | 0015125 | molecular_function | bile acid transmembrane transporter activity |
| B | 0015562 | molecular_function | efflux transmembrane transporter activity |
| B | 0015721 | biological_process | bile acid and bile salt transport |
| B | 0016020 | cellular_component | membrane |
| B | 0022857 | molecular_function | transmembrane transporter activity |
| B | 0042908 | biological_process | xenobiotic transport |
| B | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| B | 0046677 | biological_process | response to antibiotic |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0098567 | cellular_component | periplasmic side of plasma membrane |
| B | 0140330 | biological_process | xenobiotic detoxification by transmembrane export across the cell outer membrane |
| B | 1990281 | cellular_component | efflux pump complex |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 242 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000250 |
| Chain | Residue | Details |
| B | MET1-PRO9 | |
| A | GLU414-ALA441 | |
| A | LEU497-SER537 | |
| A | GLU891-PRO896 | |
| A | GLU945-PRO971 | |
| A | ARG1027-GLU1037 | |
| B | GLN360-THR365 | |
| B | GLU414-ALA441 | |
| B | LEU497-SER537 | |
| B | GLU891-PRO896 | |
| B | GLU945-PRO971 | |
| B | ARG1027-GLU1037 | |
| A | MET1-PRO9 | |
| A | GLN360-THR365 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 36 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000250 |
| Chain | Residue | Details |
| B | ILE10-PHE28 | |
| A | ILE10-PHE28 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1314 |
| Details | TOPO_DOM: Periplasmic => ECO:0000250 |
| Chain | Residue | Details |
| B | SER29-ASP339 | |
| A | ARG557-GLN870 | |
| A | ARG917-ASP922 | |
| A | GLY991-GLY1003 | |
| B | PHE386-ASN391 | |
| B | GLY461-THR473 | |
| B | ARG557-GLN870 | |
| B | ARG917-ASP922 | |
| B | GLY991-GLY1003 | |
| A | SER29-ASP339 | |
| A | PHE386-ASN391 | |
| A | GLY461-THR473 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 38 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000250 |
| Chain | Residue | Details |
| B | VAL340-LEU359 | |
| A | VAL340-LEU359 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 38 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000250 |
| Chain | Residue | Details |
| B | LEU366-ALA385 | |
| A | LEU366-ALA385 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 42 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000250 |
| Chain | Residue | Details |
| B | THR392-VAL413 | |
| A | THR392-VAL413 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 36 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000250 |
| Chain | Residue | Details |
| B | LEU442-GLY460 | |
| A | LEU442-GLY460 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 44 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000250 |
| Chain | Residue | Details |
| B | ILE474-LEU496 | |
| A | ILE474-LEU496 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 36 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000250 |
| Chain | Residue | Details |
| B | LEU538-LEU556 | |
| A | LEU538-LEU556 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 38 |
| Details | TRANSMEM: Helical; Name=8 => ECO:0000250 |
| Chain | Residue | Details |
| B | ALA871-TYR890 | |
| A | ALA871-TYR890 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 38 |
| Details | TRANSMEM: Helical; Name=9 => ECO:0000250 |
| Chain | Residue | Details |
| B | PHE897-MET916 | |
| A | PHE897-MET916 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 42 |
| Details | TRANSMEM: Helical; Name=10 => ECO:0000250 |
| Chain | Residue | Details |
| B | VAL923-VAL944 | |
| A | VAL923-VAL944 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 36 |
| Details | TRANSMEM: Helical; Name=11 => ECO:0000250 |
| Chain | Residue | Details |
| B | ILE972-THR990 | |
| A | ILE972-THR990 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 44 |
| Details | TRANSMEM: Helical; Name=12 => ECO:0000250 |
| Chain | Residue | Details |
| B | VAL1004-VAL1026 | |
| A | VAL1004-VAL1026 |
