8F3E

Trimer of aminoglycoside efflux pump AcrD

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0009636	biological_process	response to toxic substance
A	0015125	molecular_function	bile acid transmembrane transporter activity
A	0015562	molecular_function	efflux transmembrane transporter activity
A	0015721	biological_process	bile acid and bile salt transport
A	0016020	cellular_component	membrane
A	0022857	molecular_function	transmembrane transporter activity
A	0042908	biological_process	xenobiotic transport
A	0042910	molecular_function	xenobiotic transmembrane transporter activity
A	0046677	biological_process	response to antibiotic
A	0055085	biological_process	transmembrane transport
A	0098567	cellular_component	periplasmic side of plasma membrane
A	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
A	1990281	cellular_component	efflux pump complex
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0009636	biological_process	response to toxic substance
B	0015125	molecular_function	bile acid transmembrane transporter activity
B	0015562	molecular_function	efflux transmembrane transporter activity
B	0015721	biological_process	bile acid and bile salt transport
B	0016020	cellular_component	membrane
B	0022857	molecular_function	transmembrane transporter activity
B	0042908	biological_process	xenobiotic transport
B	0042910	molecular_function	xenobiotic transmembrane transporter activity
B	0046677	biological_process	response to antibiotic
B	0055085	biological_process	transmembrane transport
B	0098567	cellular_component	periplasmic side of plasma membrane
B	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
B	1990281	cellular_component	efflux pump complex
C	0005515	molecular_function	protein binding
C	0005886	cellular_component	plasma membrane
C	0009636	biological_process	response to toxic substance
C	0015125	molecular_function	bile acid transmembrane transporter activity
C	0015562	molecular_function	efflux transmembrane transporter activity
C	0015721	biological_process	bile acid and bile salt transport
C	0016020	cellular_component	membrane
C	0022857	molecular_function	transmembrane transporter activity
C	0042908	biological_process	xenobiotic transport
C	0042910	molecular_function	xenobiotic transmembrane transporter activity
C	0046677	biological_process	response to antibiotic
C	0055085	biological_process	transmembrane transport
C	0098567	cellular_component	periplasmic side of plasma membrane
C	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
C	1990281	cellular_component	efflux pump complex

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	363
Details	TOPO_DOM: Cytoplasmic => ECO:0000250

Chain	Residue	Details
A	MET1-PRO9
B	GLU414-ALA441
B	LEU497-SER537
B	GLU891-PRO896
B	GLU945-PRO971
B	ARG1027-GLU1037
C	MET1-PRO9
C	GLN360-THR365
C	GLU414-ALA441
C	LEU497-SER537
C	GLU891-PRO896
A	GLN360-THR365
C	GLU945-PRO971
C	ARG1027-GLU1037
A	GLU414-ALA441
A	LEU497-SER537
A	GLU891-PRO896
A	GLU945-PRO971
A	ARG1027-GLU1037
B	MET1-PRO9
B	GLN360-THR365

---

site_id	SWS_FT_FI2
Number of Residues	54
Details	TRANSMEM: Helical; Name=1 => ECO:0000250

Chain	Residue	Details
A	ILE10-PHE28
B	ILE10-PHE28
C	ILE10-PHE28

---

site_id	SWS_FT_FI3
Number of Residues	1971
Details	TOPO_DOM: Periplasmic => ECO:0000250

Chain	Residue	Details
A	SER29-ASP339
B	ARG557-GLN870
B	ARG917-ASP922
B	GLY991-GLY1003
C	SER29-ASP339
C	PHE386-ASN391
C	GLY461-THR473
C	ARG557-GLN870
C	ARG917-ASP922
C	GLY991-GLY1003
A	PHE386-ASN391
A	GLY461-THR473
A	ARG557-GLN870
A	ARG917-ASP922
A	GLY991-GLY1003
B	SER29-ASP339
B	PHE386-ASN391
B	GLY461-THR473

---

site_id	SWS_FT_FI4
Number of Residues	57
Details	TRANSMEM: Helical; Name=2 => ECO:0000250

Chain	Residue	Details
A	VAL340-LEU359
B	VAL340-LEU359
C	VAL340-LEU359

---

site_id	SWS_FT_FI5
Number of Residues	57
Details	TRANSMEM: Helical; Name=3 => ECO:0000250

Chain	Residue	Details
A	LEU366-ALA385
B	LEU366-ALA385
C	LEU366-ALA385

---

site_id	SWS_FT_FI6
Number of Residues	63
Details	TRANSMEM: Helical; Name=4 => ECO:0000250

Chain	Residue	Details
A	THR392-VAL413
B	THR392-VAL413
C	THR392-VAL413

---

site_id	SWS_FT_FI7
Number of Residues	54
Details	TRANSMEM: Helical; Name=5 => ECO:0000250

Chain	Residue	Details
A	LEU442-GLY460
B	LEU442-GLY460
C	LEU442-GLY460

---

site_id	SWS_FT_FI8
Number of Residues	66
Details	TRANSMEM: Helical; Name=6 => ECO:0000250

Chain	Residue	Details
A	ILE474-LEU496
B	ILE474-LEU496
C	ILE474-LEU496

---

site_id	SWS_FT_FI9
Number of Residues	54
Details	TRANSMEM: Helical; Name=7 => ECO:0000250

Chain	Residue	Details
A	LEU538-LEU556
B	LEU538-LEU556
C	LEU538-LEU556

---

site_id	SWS_FT_FI10
Number of Residues	57
Details	TRANSMEM: Helical; Name=8 => ECO:0000250

Chain	Residue	Details
A	ALA871-TYR890
B	ALA871-TYR890
C	ALA871-TYR890

---

site_id	SWS_FT_FI11
Number of Residues	57
Details	TRANSMEM: Helical; Name=9 => ECO:0000250

Chain	Residue	Details
A	PHE897-MET916
B	PHE897-MET916
C	PHE897-MET916

---

site_id	SWS_FT_FI12
Number of Residues	63
Details	TRANSMEM: Helical; Name=10 => ECO:0000250

Chain	Residue	Details
A	VAL923-VAL944
B	VAL923-VAL944
C	VAL923-VAL944

---

site_id	SWS_FT_FI13
Number of Residues	54
Details	TRANSMEM: Helical; Name=11 => ECO:0000250

Chain	Residue	Details
A	ILE972-THR990
B	ILE972-THR990
C	ILE972-THR990

---

site_id	SWS_FT_FI14
Number of Residues	66
Details	TRANSMEM: Helical; Name=12 => ECO:0000250

Chain	Residue	Details
A	VAL1004-VAL1026
B	VAL1004-VAL1026
C	VAL1004-VAL1026

---