8F30

LSD1-CoREST in complex with AW2, long soaking

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000781	cellular_component	chromosome, telomeric region
A	0000785	cellular_component	chromatin
A	0001837	biological_process	epithelial to mesenchymal transition
A	0002039	molecular_function	p53 binding
A	0002052	biological_process	positive regulation of neuroblast proliferation
A	0003682	molecular_function	chromatin binding
A	0003713	molecular_function	transcription coactivator activity
A	0003714	molecular_function	transcription corepressor activity
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005667	cellular_component	transcription regulator complex
A	0005694	cellular_component	chromosome
A	0006325	biological_process	chromatin organization
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006357	biological_process	regulation of transcription by RNA polymerase II
A	0010569	biological_process	regulation of double-strand break repair via homologous recombination
A	0010718	biological_process	positive regulation of epithelial to mesenchymal transition
A	0010976	biological_process	positive regulation of neuron projection development
A	0016491	molecular_function	oxidoreductase activity
A	0019899	molecular_function	enzyme binding
A	0021987	biological_process	cerebral cortex development
A	0031398	biological_process	positive regulation of protein ubiquitination
A	0032452	molecular_function	histone demethylase activity
A	0032453	molecular_function	histone H3K4 demethylase activity
A	0032454	molecular_function	histone H3K9 demethylase activity
A	0032880	biological_process	regulation of protein localization
A	0032991	cellular_component	protein-containing complex
A	0034644	biological_process	cellular response to UV
A	0035097	cellular_component	histone methyltransferase complex
A	0036211	biological_process	protein modification process
A	0040029	biological_process	epigenetic regulation of gene expression
A	0042162	molecular_function	telomeric DNA binding
A	0042551	biological_process	neuron maturation
A	0042802	molecular_function	identical protein binding
A	0043426	molecular_function	MRF binding
A	0043518	biological_process	negative regulation of DNA damage response, signal transduction by p53 class mediator
A	0045597	biological_process	positive regulation of cell differentiation
A	0045793	biological_process	positive regulation of cell size
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0046098	biological_process	guanine metabolic process
A	0050660	molecular_function	flavin adenine dinucleotide binding
A	0050681	molecular_function	nuclear androgen receptor binding
A	0050767	biological_process	regulation of neurogenesis
A	0051240	biological_process	positive regulation of multicellular organismal process
A	0055001	biological_process	muscle cell development
A	0060765	biological_process	regulation of androgen receptor signaling pathway
A	0060992	biological_process	response to fungicide
A	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
A	0061752	molecular_function	telomeric repeat-containing RNA binding
A	0071320	biological_process	cellular response to cAMP
A	0071480	biological_process	cellular response to gamma radiation
A	0120162	biological_process	positive regulation of cold-induced thermogenesis
A	0140297	molecular_function	DNA-binding transcription factor binding
A	0140457	molecular_function	protein demethylase activity
A	0140682	molecular_function	FAD-dependent H3K4me/H3K4me3 demethylase activity
A	0140861	biological_process	DNA repair-dependent chromatin remodeling
A	0160217	biological_process	negative regulation of transcription initiation-coupled chromatin remodeling
A	1902166	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
A	1902254	biological_process	negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
A	1990391	cellular_component	DNA repair complex
A	1990841	molecular_function	promoter-specific chromatin binding
A	2000179	biological_process	positive regulation of neural precursor cell proliferation
A	2000648	biological_process	positive regulation of stem cell proliferation

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	99
Details	Domain: {"description":"SWIRM","evidences":[{"source":"PROSITE-ProRule","id":"PRU00247","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	121
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16885027","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16956976","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21300290","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23721412","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2DW4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2H94","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HKO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2IW5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2V1D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2X0L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XAF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XAG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XAH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XAJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XAQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XAS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2Y48","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZMS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZMT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZMU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZMV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZMZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZN0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZN1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	3
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"27292636","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI7
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"25018020","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI8
Number of Residues	51
Details	Domain: {"description":"SANT 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00624","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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