Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8F2L

Crystal structure of Mycobacterium tuberculosis Homoserine transacetylase in complex with L-Homoserine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004414	molecular_function	homoserine O-acetyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0005886	cellular_component	plasma membrane
A	0009058	biological_process	biosynthetic process
A	0009086	biological_process	methionine biosynthetic process
A	0009092	biological_process	homoserine metabolic process
A	0016746	molecular_function	acyltransferase activity
A	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
B	0003824	molecular_function	catalytic activity
B	0004414	molecular_function	homoserine O-acetyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0005886	cellular_component	plasma membrane
B	0009058	biological_process	biosynthetic process
B	0009086	biological_process	methionine biosynthetic process
B	0009092	biological_process	homoserine metabolic process
B	0016746	molecular_function	acyltransferase activity
B	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
C	0003824	molecular_function	catalytic activity
C	0004414	molecular_function	homoserine O-acetyltransferase activity
C	0005737	cellular_component	cytoplasm
C	0005886	cellular_component	plasma membrane
C	0009058	biological_process	biosynthetic process
C	0009086	biological_process	methionine biosynthetic process
C	0009092	biological_process	homoserine metabolic process
C	0016746	molecular_function	acyltransferase activity
C	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
D	0003824	molecular_function	catalytic activity
D	0004414	molecular_function	homoserine O-acetyltransferase activity
D	0005737	cellular_component	cytoplasm
D	0005886	cellular_component	plasma membrane
D	0009058	biological_process	biosynthetic process
D	0009086	biological_process	methionine biosynthetic process
D	0009092	biological_process	homoserine metabolic process
D	0016746	molecular_function	acyltransferase activity
D	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
E	0003824	molecular_function	catalytic activity
E	0004414	molecular_function	homoserine O-acetyltransferase activity
E	0005737	cellular_component	cytoplasm
E	0005886	cellular_component	plasma membrane
E	0009058	biological_process	biosynthetic process
E	0009086	biological_process	methionine biosynthetic process
E	0009092	biological_process	homoserine metabolic process
E	0016746	molecular_function	acyltransferase activity
E	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
F	0003824	molecular_function	catalytic activity
F	0004414	molecular_function	homoserine O-acetyltransferase activity
F	0005737	cellular_component	cytoplasm
F	0005886	cellular_component	plasma membrane
F	0009058	biological_process	biosynthetic process
F	0009086	biological_process	methionine biosynthetic process
F	0009092	biological_process	homoserine metabolic process
F	0016746	molecular_function	acyltransferase activity
F	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
G	0003824	molecular_function	catalytic activity
G	0004414	molecular_function	homoserine O-acetyltransferase activity
G	0005737	cellular_component	cytoplasm
G	0005886	cellular_component	plasma membrane
G	0009058	biological_process	biosynthetic process
G	0009086	biological_process	methionine biosynthetic process
G	0009092	biological_process	homoserine metabolic process
G	0016746	molecular_function	acyltransferase activity
G	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
H	0003824	molecular_function	catalytic activity
H	0004414	molecular_function	homoserine O-acetyltransferase activity
H	0005737	cellular_component	cytoplasm
H	0005886	cellular_component	plasma membrane
H	0009058	biological_process	biosynthetic process
H	0009086	biological_process	methionine biosynthetic process
H	0009092	biological_process	homoserine metabolic process
H	0016746	molecular_function	acyltransferase activity
H	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
I	0003824	molecular_function	catalytic activity
I	0004414	molecular_function	homoserine O-acetyltransferase activity
I	0005737	cellular_component	cytoplasm
I	0005886	cellular_component	plasma membrane
I	0009058	biological_process	biosynthetic process
I	0009086	biological_process	methionine biosynthetic process
I	0009092	biological_process	homoserine metabolic process
I	0016746	molecular_function	acyltransferase activity
I	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
J	0003824	molecular_function	catalytic activity
J	0004414	molecular_function	homoserine O-acetyltransferase activity
J	0005737	cellular_component	cytoplasm
J	0005886	cellular_component	plasma membrane
J	0009058	biological_process	biosynthetic process
J	0009086	biological_process	methionine biosynthetic process
J	0009092	biological_process	homoserine metabolic process
J	0016746	molecular_function	acyltransferase activity
J	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
K	0003824	molecular_function	catalytic activity
K	0004414	molecular_function	homoserine O-acetyltransferase activity
K	0005737	cellular_component	cytoplasm
K	0005886	cellular_component	plasma membrane
K	0009058	biological_process	biosynthetic process
K	0009086	biological_process	methionine biosynthetic process
K	0009092	biological_process	homoserine metabolic process
K	0016746	molecular_function	acyltransferase activity
K	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
L	0003824	molecular_function	catalytic activity
L	0004414	molecular_function	homoserine O-acetyltransferase activity
L	0005737	cellular_component	cytoplasm
L	0005886	cellular_component	plasma membrane
L	0009058	biological_process	biosynthetic process
L	0009086	biological_process	methionine biosynthetic process
L	0009092	biological_process	homoserine metabolic process
L	0016746	molecular_function	acyltransferase activity
L	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	ACT_SITE: Nucleophile => ECO:0000255\|HAMAP-Rule:MF_00296

Chain	Residue	Details
B	SER157
J	SER157
K	SER157
L	SER157
A	SER157
C	SER157
D	SER157
E	SER157
F	SER157
G	SER157
H	SER157
I	SER157

site_id	SWS_FT_FI2
Number of Residues	24
Details	ACT_SITE: ACT_SITE => ECO:0000255\|HAMAP-Rule:MF_00296

Chain	Residue	Details
B	ASP320
E	HIS350
F	ASP320
F	HIS350
G	ASP320
G	HIS350
H	ASP320
H	HIS350
I	ASP320
I	HIS350
J	ASP320
B	HIS350
J	HIS350
K	ASP320
K	HIS350
L	ASP320
L	HIS350
A	ASP320
A	HIS350
C	ASP320
C	HIS350
D	ASP320
D	HIS350
E	ASP320

site_id	SWS_FT_FI3
Number of Residues	24
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00296

Chain	Residue	Details
B	ARG227
E	ASP351
F	ARG227
F	ASP351
G	ARG227
G	ASP351
H	ARG227
H	ASP351
I	ARG227
I	ASP351
J	ARG227
B	ASP351
J	ASP351
K	ARG227
K	ASP351
L	ARG227
L	ASP351
A	ARG227
A	ASP351
C	ARG227
C	ASP351
D	ARG227
D	ASP351
E	ARG227

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)