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8F2I

P53 monomer structure

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000423biological_processmitophagy
A0000785cellular_componentchromatin
A0000976molecular_functiontranscription cis-regulatory region binding
A0000977molecular_functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
A0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
A0000981molecular_functionDNA-binding transcription factor activity, RNA polymerase II-specific
A0000987molecular_functioncis-regulatory region sequence-specific DNA binding
A0001046molecular_functioncore promoter sequence-specific DNA binding
A0001094molecular_functionTFIID-class transcription factor complex binding
A0001227molecular_functionDNA-binding transcription repressor activity, RNA polymerase II-specific
A0001228molecular_functionDNA-binding transcription activator activity, RNA polymerase II-specific
A0001701biological_processin utero embryonic development
A0001756biological_processsomitogenesis
A0001836biological_processrelease of cytochrome c from mitochondria
A0002020molecular_functionprotease binding
A0002039molecular_functionp53 binding
A0002244biological_processhematopoietic progenitor cell differentiation
A0002309biological_processT cell proliferation involved in immune response
A0002326biological_processB cell lineage commitment
A0002360biological_processT cell lineage commitment
A0002931biological_processresponse to ischemia
A0003677molecular_functionDNA binding
A0003682molecular_functionchromatin binding
A0003700molecular_functionDNA-binding transcription factor activity
A0003730molecular_functionmRNA 3'-UTR binding
A0005507molecular_functioncopper ion binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005657cellular_componentreplication fork
A0005667cellular_componenttranscription regulator complex
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005759cellular_componentmitochondrial matrix
A0005783cellular_componentendoplasmic reticulum
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0006289biological_processnucleotide-excision repair
A0006302biological_processdouble-strand break repair
A0006355biological_processregulation of DNA-templated transcription
A0006357biological_processregulation of transcription by RNA polymerase II
A0006606biological_processprotein import into nucleus
A0006914biological_processautophagy
A0006915biological_processapoptotic process
A0006974biological_processDNA damage response
A0006977biological_processDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
A0006978biological_processDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
A0006979biological_processresponse to oxidative stress
A0006983biological_processER overload response
A0007179biological_processtransforming growth factor beta receptor signaling pathway
A0007265biological_processRas protein signal transduction
A0007346biological_processregulation of mitotic cell cycle
A0007369biological_processgastrulation
A0007405biological_processneuroblast proliferation
A0007406biological_processnegative regulation of neuroblast proliferation
A0007417biological_processcentral nervous system development
A0007507biological_processheart development
A0007623biological_processcircadian rhythm
A0008104biological_processprotein localization
A0008156biological_processnegative regulation of DNA replication
A0008270molecular_functionzinc ion binding
A0008283biological_processcell population proliferation
A0008285biological_processnegative regulation of cell population proliferation
A0008340biological_processdetermination of adult lifespan
A0009299biological_processmRNA transcription
A0009303biological_processrRNA transcription
A0009410biological_processresponse to xenobiotic stimulus
A0009411biological_processresponse to UV
A0009651biological_processresponse to salt stress
A0009792biological_processembryo development ending in birth or egg hatching
A0010165biological_processresponse to X-ray
A0010332biological_processresponse to gamma radiation
A0010628biological_processpositive regulation of gene expression
A0010629biological_processnegative regulation of gene expression
A0010659biological_processcardiac muscle cell apoptotic process
A0010666biological_processpositive regulation of cardiac muscle cell apoptotic process
A0014009biological_processglial cell proliferation
A0016032biological_processviral process
A0016363cellular_componentnuclear matrix
A0016604cellular_componentnuclear body
A0016605cellular_componentPML body
A0017053cellular_componenttranscription repressor complex
A0019661biological_processglucose catabolic process to lactate via pyruvate
A0019899molecular_functionenzyme binding
A0021549biological_processcerebellum development
A0030308biological_processnegative regulation of cell growth
A0030330biological_processDNA damage response, signal transduction by p53 class mediator
A0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
A0030971molecular_functionreceptor tyrosine kinase binding
A0031571biological_processmitotic G1 DNA damage checkpoint signaling
A0031625molecular_functionubiquitin protein ligase binding
A0032211biological_processnegative regulation of telomere maintenance via telomerase
A0032991cellular_componentprotein-containing complex
A0033077biological_processT cell differentiation in thymus
A0033209biological_processtumor necrosis factor-mediated signaling pathway
A0033554biological_processcellular response to stress
A0034103biological_processregulation of tissue remodeling
A0034644biological_processcellular response to UV
A0035033molecular_functionhistone deacetylase regulator activity
A0035264biological_processmulticellular organism growth
A0035794biological_processpositive regulation of mitochondrial membrane permeability
A0035861cellular_componentsite of double-strand break
A0036310molecular_functionATP-dependent DNA/DNA annealing activity
A0042127biological_processregulation of cell population proliferation
A0042149biological_processcellular response to glucose starvation
A0042771biological_processintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
A0042802molecular_functionidentical protein binding
A0042826molecular_functionhistone deacetylase binding
A0042981biological_processregulation of apoptotic process
A0043065biological_processpositive regulation of apoptotic process
A0043066biological_processnegative regulation of apoptotic process
A0043073cellular_componentgerm cell nucleus
A0043153biological_processentrainment of circadian clock by photoperiod
A0043504biological_processmitochondrial DNA repair
A0043516biological_processregulation of DNA damage response, signal transduction by p53 class mediator
A0043523biological_processregulation of neuron apoptotic process
A0043525biological_processpositive regulation of neuron apoptotic process
A0043621molecular_functionobsolete protein self-association
A0045815biological_processtranscription initiation-coupled chromatin remodeling
A0045861biological_processnegative regulation of proteolysis
A0045892biological_processnegative regulation of DNA-templated transcription
A0045893biological_processpositive regulation of DNA-templated transcription
A0045899biological_processpositive regulation of RNA polymerase II transcription preinitiation complex assembly
A0045930biological_processnegative regulation of mitotic cell cycle
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046677biological_processresponse to antibiotic
A0046872molecular_functionmetal ion binding
A0046982molecular_functionprotein heterodimerization activity
A0048144biological_processfibroblast proliferation
A0048147biological_processnegative regulation of fibroblast proliferation
A0048511biological_processrhythmic process
A0048512biological_processcircadian behavior
A0048539biological_processbone marrow development
A0048568biological_processembryonic organ development
A0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
A0050821biological_processprotein stabilization
A0051087molecular_functionprotein-folding chaperone binding
A0051097biological_processnegative regulation of helicase activity
A0051262biological_processprotein tetramerization
A0051276biological_processchromosome organization
A0051402biological_processneuron apoptotic process
A0051721molecular_functionprotein phosphatase 2A binding
A0051726biological_processregulation of cell cycle
A0060218biological_processhematopoietic stem cell differentiation
A0060253biological_processnegative regulation of glial cell proliferation
A0060333biological_processtype II interferon-mediated signaling pathway
A0060411biological_processcardiac septum morphogenesis
A0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
A0062100biological_processpositive regulation of programmed necrotic cell death
A0065003biological_processprotein-containing complex assembly
A0070059biological_processintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
A0070242biological_processthymocyte apoptotic process
A0070243biological_processregulation of thymocyte apoptotic process
A0070245biological_processpositive regulation of thymocyte apoptotic process
A0070266biological_processnecroptotic process
A0071456biological_processcellular response to hypoxia
A0071466biological_processcellular response to xenobiotic stimulus
A0071479biological_processcellular response to ionizing radiation
A0071480biological_processcellular response to gamma radiation
A0071494biological_processcellular response to UV-C
A0071889molecular_function14-3-3 protein binding
A0072089biological_processstem cell proliferation
A0072331biological_processsignal transduction by p53 class mediator
A0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
A0072593biological_processreactive oxygen species metabolic process
A0072717biological_processcellular response to actinomycin D
A0090200biological_processpositive regulation of release of cytochrome c from mitochondria
A0090398biological_processcellular senescence
A0090399biological_processreplicative senescence
A0090403biological_processoxidative stress-induced premature senescence
A0097193biological_processintrinsic apoptotic signaling pathway
A0097252biological_processoligodendrocyte apoptotic process
A0097371molecular_functionMDM2/MDM4 family protein binding
A0097718molecular_functiondisordered domain specific binding
A0140296molecular_functiongeneral transcription initiation factor binding
A0140677molecular_functionmolecular function activator activity
A0140693molecular_functionmolecular condensate scaffold activity
A1900119biological_processpositive regulation of execution phase of apoptosis
A1901525biological_processnegative regulation of mitophagy
A1902108biological_processregulation of mitochondrial membrane permeability involved in apoptotic process
A1902253biological_processregulation of intrinsic apoptotic signaling pathway by p53 class mediator
A1902749biological_processregulation of cell cycle G2/M phase transition
A1902895biological_processpositive regulation of miRNA transcription
A1903451biological_processnegative regulation of G1 to G0 transition
A1903799biological_processnegative regulation of miRNA processing
A1904024biological_processnegative regulation of glucose catabolic process to lactate via pyruvate
A1905856biological_processnegative regulation of pentose-phosphate shunt
A1990144biological_processintrinsic apoptotic signaling pathway in response to hypoxia
A1990841molecular_functionpromoter-specific chromatin binding
A2000269biological_processregulation of fibroblast apoptotic process
A2000378biological_processnegative regulation of reactive oxygen species metabolic process
A2000379biological_processpositive regulation of reactive oxygen species metabolic process
A2000647biological_processnegative regulation of stem cell proliferation
A2000772biological_processregulation of cellular senescence
A2000774biological_processpositive regulation of cellular senescence
A2001244biological_processpositive regulation of intrinsic apoptotic signaling pathway
Functional Information from PROSITE/UniProt
site_idPS00348
Number of Residues13
DetailsP53 p53 family signature. MCNSSCMGGMNRR
ChainResidueDetails
AMET237-ARG249

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues190
DetailsDNA_BIND: DNA_BIND => ECO:0000269|PubMed:16793544, ECO:0000269|PubMed:18996393, ECO:0000269|PubMed:20364130
ChainResidueDetails
ATHR102-LYS292

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:14534297, ECO:0000269|PubMed:16793544, ECO:0000269|PubMed:17015838, ECO:0000269|PubMed:18650397, ECO:0000269|PubMed:19515728, ECO:0000269|PubMed:20142040, ECO:0000269|PubMed:20364130
ChainResidueDetails
ACYS176
AHIS179
ACYS238
ACYS242

site_idSWS_FT_FI3
Number of Residues1
DetailsSITE: Interaction with DNA => ECO:0000269|PubMed:16793544, ECO:0000269|PubMed:18996393, ECO:0000269|PubMed:20364130
ChainResidueDetails
ALYS120

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine; by HIPK4 => ECO:0000269|PubMed:18022393
ChainResidueDetails
ASER9

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine; by CDK5, PRPK, AMPK, NUAK1 and ATM => ECO:0000269|PubMed:10570149, ECO:0000269|PubMed:11554766, ECO:0000269|PubMed:15866171, ECO:0000269|PubMed:17108107, ECO:0000269|PubMed:17591690, ECO:0000269|PubMed:17967874, ECO:0000269|PubMed:21317932, ECO:0000269|PubMed:28842590
ChainResidueDetails
ASER15

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by CK1, VRK1 and VRK2 => ECO:0000269|PubMed:10606744, ECO:0000269|PubMed:10951572, ECO:0000269|PubMed:16704422, ECO:0000269|PubMed:31527692
ChainResidueDetails
ATHR18

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphoserine; by CHEK2, CK1 and PLK3 => ECO:0000269|PubMed:10570149, ECO:0000269|PubMed:11447225, ECO:0000269|PubMed:11551930, ECO:0000269|PubMed:12810724, ECO:0000269|PubMed:20041275
ChainResidueDetails
ASER20

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphoserine; by CDK5 and CDK7 => ECO:0000269|PubMed:17591690, ECO:0000269|PubMed:9372954
ChainResidueDetails
ASER33

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: Phosphoserine; by MAPKAPK5 => ECO:0000269|PubMed:17254968
ChainResidueDetails
ASER37

site_idSWS_FT_FI10
Number of Residues1
DetailsMOD_RES: Phosphoserine; by CDK5, DYRK2, HIPK2 and PKC/PRKCG => ECO:0000269|PubMed:11740489, ECO:0000269|PubMed:11780126, ECO:0000269|PubMed:16377624, ECO:0000269|PubMed:17349958, ECO:0000269|PubMed:17591690
ChainResidueDetails
ASER46

site_idSWS_FT_FI11
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by TAF1 and GRK5 => ECO:0000269|PubMed:15053879, ECO:0000269|PubMed:20124405
ChainResidueDetails
ATHR55

site_idSWS_FT_FI12
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:17189187, ECO:0000269|PubMed:19854137, ECO:0000269|PubMed:23431171
ChainResidueDetails
ALYS120

site_idSWS_FT_FI13
Number of Residues2
DetailsMOD_RES: Phosphoserine; by AURKB => ECO:0000269|PubMed:20959462
ChainResidueDetails
ASER183
ASER269

site_idSWS_FT_FI14
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by AURKB => ECO:0000269|PubMed:20959462
ChainResidueDetails
ATHR284

site_idSWS_FT_FI15
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:12724314
ChainResidueDetails
ALYS305

site_idSWS_FT_FI16
Number of Residues1
DetailsMOD_RES: Phosphoserine; by AURKA, CDK1 and CDK2 => ECO:0000269|PubMed:10884347, ECO:0000269|PubMed:14702041
ChainResidueDetails
ASER315

site_idSWS_FT_FI17
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P02340
ChainResidueDetails
ALYS321

site_idSWS_FT_FI18
Number of Residues1
DetailsMOD_RES: Omega-N-methylarginine; by PRMT5 => ECO:0000269|PubMed:19011621
ChainResidueDetails
AARG333

site_idSWS_FT_FI19
Number of Residues2
DetailsMOD_RES: Symmetric dimethylarginine; by PRMT5 => ECO:0000269|PubMed:19011621
ChainResidueDetails
AARG335
AARG337

site_idSWS_FT_FI20
Number of Residues1
DetailsMOD_RES: N6-methyllysine; by SMYD2; alternate => ECO:0000269|PubMed:17108971, ECO:0000269|PubMed:22864287
ChainResidueDetails
ALYS370

site_idSWS_FT_FI21
Number of Residues1
DetailsMOD_RES: N6-methyllysine; by SETD7 => ECO:0000269|PubMed:15525938, ECO:0000269|PubMed:16415881
ChainResidueDetails
ALYS372

site_idSWS_FT_FI22
Number of Residues1
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0000269|PubMed:10656795
ChainResidueDetails
ALYS373

site_idSWS_FT_FI23
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:29474172, ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS381

site_idSWS_FT_FI24
Number of Residues1
DetailsMOD_RES: N6-methyllysine; by KMT5A; alternate => ECO:0000269|PubMed:17707234, ECO:0000269|PubMed:20870725, ECO:0000269|PubMed:22864287
ChainResidueDetails
ALYS382

site_idSWS_FT_FI25
Number of Residues1
DetailsMOD_RES: Phosphoserine; by CK2, CDK2 and NUAK1 => ECO:0000269|PubMed:10884347, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:17108107, ECO:0000269|PubMed:21317932, ECO:0000269|PubMed:22214662
ChainResidueDetails
ASER392

site_idSWS_FT_FI26
Number of Residues1
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:21597459
ChainResidueDetails
ALYS24

site_idSWS_FT_FI27
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:11124955, ECO:0000269|PubMed:22214662, ECO:0000269|Ref.37
ChainResidueDetails
ALYS386

site_idSWS_FT_FI28
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:19536131
ChainResidueDetails
ALYS291
ALYS292

site_idSWS_FT_FI29
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:19033443
ChainResidueDetails
ALYS351
ALYS357

224004

PDB entries from 2024-08-21

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