8EYK
Atomic model of the core modifying region of human fatty acid synthase in complex with TVB-2640
Functional Information from GO Data
Chain | GOid | namespace | contents |
E | 0009058 | biological_process | biosynthetic process |
E | 0016491 | molecular_function | oxidoreductase activity |
E | 0031177 | molecular_function | phosphopantetheine binding |
F | 0009058 | biological_process | biosynthetic process |
F | 0016491 | molecular_function | oxidoreductase activity |
F | 0031177 | molecular_function | phosphopantetheine binding |
Functional Information from PROSITE/UniProt
site_id | PS00012 |
Number of Residues | 16 |
Details | PHOSPHOPANTETHEINE Phosphopantetheine attachment site. DLGLDSLMSVEVRQTL |
Chain | Residue | Details |
E | ASP2151-LEU2166 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Proton acceptor; for dehydratase activity => ECO:0000255|PROSITE-ProRule:PRU01363 |
Chain | Residue | Details |
E | HIS878 | |
F | HIS878 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | ACT_SITE: Proton donor; for dehydratase activity => ECO:0000255|PROSITE-ProRule:PRU01363 |
Chain | Residue | Details |
F | ASP1031 | |
E | ASP1031 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | ACT_SITE: For thioesterase activity => ECO:0000255|PROSITE-ProRule:PRU10022, ECO:0000269|PubMed:17618296 |
Chain | Residue | Details |
E | SER2308 | |
F | SER2308 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | ACT_SITE: For thioesterase activity => ECO:0000255|PROSITE-ProRule:PRU10022 |
Chain | Residue | Details |
E | HIS2481 | |
F | HIS2481 |
site_id | SWS_FT_FI5 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
F | SER1886 | |
E | LEU1671 | |
E | SER1886 | |
F | LEU1671 |
site_id | SWS_FT_FI6 |
Number of Residues | 4 |
Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P19096 |
Chain | Residue | Details |
F | LYS992 | |
F | LYS2391 | |
E | LYS992 | |
E | LYS2391 |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
E | SER1174 | |
F | SER1174 |
site_id | SWS_FT_FI8 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
F | SER1411 | |
E | SER1411 |
site_id | SWS_FT_FI9 |
Number of Residues | 4 |
Details | MOD_RES: S-nitrosocysteine => ECO:0000269|PubMed:26851298 |
Chain | Residue | Details |
F | CYS1471 | |
F | CYS2091 | |
E | CYS1471 | |
E | CYS2091 |
site_id | SWS_FT_FI10 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
F | SER1584 | |
E | SER1584 |
site_id | SWS_FT_FI11 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P19096 |
Chain | Residue | Details |
E | SER1594 | |
F | SER1594 |
site_id | SWS_FT_FI12 |
Number of Residues | 2 |
Details | MOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861 |
Chain | Residue | Details |
E | LYS1704 | |
F | LYS1704 |
site_id | SWS_FT_FI13 |
Number of Residues | 6 |
Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
Chain | Residue | Details |
E | LYS1995 | |
F | LYS1771 | |
F | LYS1847 | |
F | LYS1995 | |
E | LYS1771 | |
E | LYS1847 |
site_id | SWS_FT_FI14 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine; alternate => ECO:0000250|UniProtKB:P12785 |
Chain | Residue | Details |
E | SER2156 | |
F | SER2156 |
site_id | SWS_FT_FI15 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
E | SER2198 | |
F | SER2198 |
site_id | SWS_FT_FI16 |
Number of Residues | 2 |
Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
E | THR2204 | |
F | THR2204 |
site_id | SWS_FT_FI17 |
Number of Residues | 2 |
Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
E | THR2215 | |
F | THR2215 |
site_id | SWS_FT_FI18 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648 |
Chain | Residue | Details |
F | SER2236 | |
E | SER2236 |
site_id | SWS_FT_FI19 |
Number of Residues | 4 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25114211 |
Chain | Residue | Details |
E | LYS2449 | |
F | LYS2449 |