8EY9

Structure of Arabidopsis fatty acid amide hydrolase mutant S305A in complex with 9-hydroxy-10,12-octadecadienoyl-ethanolamide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000325	cellular_component	plant-type vacuole
A	0003824	molecular_function	catalytic activity
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005794	cellular_component	Golgi apparatus
A	0005886	cellular_component	plasma membrane
A	0006629	biological_process	lipid metabolic process
A	0009536	cellular_component	plastid
A	0016020	cellular_component	membrane
A	0016042	biological_process	lipid catabolic process
A	0016787	molecular_function	hydrolase activity
A	0016811	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
A	0017064	molecular_function	fatty acid amide hydrolase activity
A	0042742	biological_process	defense response to bacterium
A	0047412	molecular_function	N-(long-chain-acyl)ethanolamine deacylase activity
A	0070291	biological_process	N-acylethanolamine metabolic process
B	0000325	cellular_component	plant-type vacuole
B	0003824	molecular_function	catalytic activity
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005794	cellular_component	Golgi apparatus
B	0005886	cellular_component	plasma membrane
B	0006629	biological_process	lipid metabolic process
B	0009536	cellular_component	plastid
B	0016020	cellular_component	membrane
B	0016042	biological_process	lipid catabolic process
B	0016787	molecular_function	hydrolase activity
B	0016811	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
B	0017064	molecular_function	fatty acid amide hydrolase activity
B	0042742	biological_process	defense response to bacterium
B	0047412	molecular_function	N-(long-chain-acyl)ethanolamine deacylase activity
B	0070291	biological_process	N-acylethanolamine metabolic process
C	0000325	cellular_component	plant-type vacuole
C	0003824	molecular_function	catalytic activity
C	0005783	cellular_component	endoplasmic reticulum
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005794	cellular_component	Golgi apparatus
C	0005886	cellular_component	plasma membrane
C	0006629	biological_process	lipid metabolic process
C	0009536	cellular_component	plastid
C	0016020	cellular_component	membrane
C	0016042	biological_process	lipid catabolic process
C	0016787	molecular_function	hydrolase activity
C	0016811	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
C	0017064	molecular_function	fatty acid amide hydrolase activity
C	0042742	biological_process	defense response to bacterium
C	0047412	molecular_function	N-(long-chain-acyl)ethanolamine deacylase activity
C	0070291	biological_process	N-acylethanolamine metabolic process
D	0000325	cellular_component	plant-type vacuole
D	0003824	molecular_function	catalytic activity
D	0005783	cellular_component	endoplasmic reticulum
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0005794	cellular_component	Golgi apparatus
D	0005886	cellular_component	plasma membrane
D	0006629	biological_process	lipid metabolic process
D	0009536	cellular_component	plastid
D	0016020	cellular_component	membrane
D	0016042	biological_process	lipid catabolic process
D	0016787	molecular_function	hydrolase activity
D	0016811	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
D	0017064	molecular_function	fatty acid amide hydrolase activity
D	0042742	biological_process	defense response to bacterium
D	0047412	molecular_function	N-(long-chain-acyl)ethanolamine deacylase activity
D	0070291	biological_process	N-acylethanolamine metabolic process
E	0000325	cellular_component	plant-type vacuole
E	0003824	molecular_function	catalytic activity
E	0005783	cellular_component	endoplasmic reticulum
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0005794	cellular_component	Golgi apparatus
E	0005886	cellular_component	plasma membrane
E	0006629	biological_process	lipid metabolic process
E	0009536	cellular_component	plastid
E	0016020	cellular_component	membrane
E	0016042	biological_process	lipid catabolic process
E	0016787	molecular_function	hydrolase activity
E	0016811	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
E	0017064	molecular_function	fatty acid amide hydrolase activity
E	0042742	biological_process	defense response to bacterium
E	0047412	molecular_function	N-(long-chain-acyl)ethanolamine deacylase activity
E	0070291	biological_process	N-acylethanolamine metabolic process
F	0000325	cellular_component	plant-type vacuole
F	0003824	molecular_function	catalytic activity
F	0005783	cellular_component	endoplasmic reticulum
F	0005789	cellular_component	endoplasmic reticulum membrane
F	0005794	cellular_component	Golgi apparatus
F	0005886	cellular_component	plasma membrane
F	0006629	biological_process	lipid metabolic process
F	0009536	cellular_component	plastid
F	0016020	cellular_component	membrane
F	0016042	biological_process	lipid catabolic process
F	0016787	molecular_function	hydrolase activity
F	0016811	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
F	0017064	molecular_function	fatty acid amide hydrolase activity
F	0042742	biological_process	defense response to bacterium
F	0047412	molecular_function	N-(long-chain-acyl)ethanolamine deacylase activity
F	0070291	biological_process	N-acylethanolamine metabolic process
G	0000325	cellular_component	plant-type vacuole
G	0003824	molecular_function	catalytic activity
G	0005783	cellular_component	endoplasmic reticulum
G	0005789	cellular_component	endoplasmic reticulum membrane
G	0005794	cellular_component	Golgi apparatus
G	0005886	cellular_component	plasma membrane
G	0006629	biological_process	lipid metabolic process
G	0009536	cellular_component	plastid
G	0016020	cellular_component	membrane
G	0016042	biological_process	lipid catabolic process
G	0016787	molecular_function	hydrolase activity
G	0016811	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
G	0017064	molecular_function	fatty acid amide hydrolase activity
G	0042742	biological_process	defense response to bacterium
G	0047412	molecular_function	N-(long-chain-acyl)ethanolamine deacylase activity
G	0070291	biological_process	N-acylethanolamine metabolic process
H	0000325	cellular_component	plant-type vacuole
H	0003824	molecular_function	catalytic activity
H	0005783	cellular_component	endoplasmic reticulum
H	0005789	cellular_component	endoplasmic reticulum membrane
H	0005794	cellular_component	Golgi apparatus
H	0005886	cellular_component	plasma membrane
H	0006629	biological_process	lipid metabolic process
H	0009536	cellular_component	plastid
H	0016020	cellular_component	membrane
H	0016042	biological_process	lipid catabolic process
H	0016787	molecular_function	hydrolase activity
H	0016811	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
H	0017064	molecular_function	fatty acid amide hydrolase activity
H	0042742	biological_process	defense response to bacterium
H	0047412	molecular_function	N-(long-chain-acyl)ethanolamine deacylase activity
H	0070291	biological_process	N-acylethanolamine metabolic process
I	0000325	cellular_component	plant-type vacuole
I	0003824	molecular_function	catalytic activity
I	0005783	cellular_component	endoplasmic reticulum
I	0005789	cellular_component	endoplasmic reticulum membrane
I	0005794	cellular_component	Golgi apparatus
I	0005886	cellular_component	plasma membrane
I	0006629	biological_process	lipid metabolic process
I	0009536	cellular_component	plastid
I	0016020	cellular_component	membrane
I	0016042	biological_process	lipid catabolic process
I	0016787	molecular_function	hydrolase activity
I	0016811	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
I	0017064	molecular_function	fatty acid amide hydrolase activity
I	0042742	biological_process	defense response to bacterium
I	0047412	molecular_function	N-(long-chain-acyl)ethanolamine deacylase activity
I	0070291	biological_process	N-acylethanolamine metabolic process
J	0000325	cellular_component	plant-type vacuole
J	0003824	molecular_function	catalytic activity
J	0005783	cellular_component	endoplasmic reticulum
J	0005789	cellular_component	endoplasmic reticulum membrane
J	0005794	cellular_component	Golgi apparatus
J	0005886	cellular_component	plasma membrane
J	0006629	biological_process	lipid metabolic process
J	0009536	cellular_component	plastid
J	0016020	cellular_component	membrane
J	0016042	biological_process	lipid catabolic process
J	0016787	molecular_function	hydrolase activity
J	0016811	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
J	0017064	molecular_function	fatty acid amide hydrolase activity
J	0042742	biological_process	defense response to bacterium
J	0047412	molecular_function	N-(long-chain-acyl)ethanolamine deacylase activity
J	0070291	biological_process	N-acylethanolamine metabolic process
K	0000325	cellular_component	plant-type vacuole
K	0003824	molecular_function	catalytic activity
K	0005783	cellular_component	endoplasmic reticulum
K	0005789	cellular_component	endoplasmic reticulum membrane
K	0005794	cellular_component	Golgi apparatus
K	0005886	cellular_component	plasma membrane
K	0006629	biological_process	lipid metabolic process
K	0009536	cellular_component	plastid
K	0016020	cellular_component	membrane
K	0016042	biological_process	lipid catabolic process
K	0016787	molecular_function	hydrolase activity
K	0016811	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
K	0017064	molecular_function	fatty acid amide hydrolase activity
K	0042742	biological_process	defense response to bacterium
K	0047412	molecular_function	N-(long-chain-acyl)ethanolamine deacylase activity
K	0070291	biological_process	N-acylethanolamine metabolic process
L	0000325	cellular_component	plant-type vacuole
L	0003824	molecular_function	catalytic activity
L	0005783	cellular_component	endoplasmic reticulum
L	0005789	cellular_component	endoplasmic reticulum membrane
L	0005794	cellular_component	Golgi apparatus
L	0005886	cellular_component	plasma membrane
L	0006629	biological_process	lipid metabolic process
L	0009536	cellular_component	plastid
L	0016020	cellular_component	membrane
L	0016042	biological_process	lipid catabolic process
L	0016787	molecular_function	hydrolase activity
L	0016811	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
L	0017064	molecular_function	fatty acid amide hydrolase activity
L	0042742	biological_process	defense response to bacterium
L	0047412	molecular_function	N-(long-chain-acyl)ethanolamine deacylase activity
L	0070291	biological_process	N-acylethanolamine metabolic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"19801664","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Active site: {"description":"Acyl-ester intermediate","evidences":[{"source":"PubMed","id":"19801664","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30894416","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6DII","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---