8EWR

Crystal structure of CYP3A4 bound to an inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002933	biological_process	lipid hydroxylation
A	0004497	molecular_function	monooxygenase activity
A	0005496	molecular_function	steroid binding
A	0005506	molecular_function	iron ion binding
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0006694	biological_process	steroid biosynthetic process
A	0006706	biological_process	steroid catabolic process
A	0006805	biological_process	xenobiotic metabolic process
A	0008202	biological_process	steroid metabolic process
A	0008203	biological_process	cholesterol metabolic process
A	0008209	biological_process	androgen metabolic process
A	0008210	biological_process	estrogen metabolic process
A	0008395	molecular_function	steroid hydroxylase activity
A	0008401	molecular_function	retinoic acid 4-hydroxylase activity
A	0009822	biological_process	alkaloid catabolic process
A	0016020	cellular_component	membrane
A	0016098	biological_process	monoterpenoid metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A	0016712	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
A	0019825	molecular_function	oxygen binding
A	0019899	molecular_function	enzyme binding
A	0020037	molecular_function	heme binding
A	0030343	molecular_function	vitamin D3 25-hydroxylase activity
A	0034875	molecular_function	caffeine oxidase activity
A	0036378	biological_process	calcitriol biosynthetic process from calciol
A	0042178	biological_process	xenobiotic catabolic process
A	0042359	biological_process	vitamin D metabolic process
A	0042369	biological_process	vitamin D catabolic process
A	0042572	biological_process	retinol metabolic process
A	0042573	biological_process	retinoic acid metabolic process
A	0042759	biological_process	long-chain fatty acid biosynthetic process
A	0043231	cellular_component	intracellular membrane-bounded organelle
A	0046222	biological_process	aflatoxin metabolic process
A	0046872	molecular_function	metal ion binding
A	0050591	molecular_function	quinine 3-monooxygenase activity
A	0050649	molecular_function	testosterone 6-beta-hydroxylase activity
A	0062181	molecular_function	1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity
A	0062187	molecular_function	anandamide 8,9 epoxidase activity
A	0062188	molecular_function	anandamide 11,12 epoxidase activity
A	0062189	molecular_function	anandamide 14,15 epoxidase activity
A	0070576	molecular_function	vitamin D 24-hydroxylase activity
A	0070989	biological_process	oxidative demethylation
A	0101020	molecular_function	estrogen 16-alpha-hydroxylase activity
A	0101021	molecular_function	estrogen 2-hydroxylase activity
A	0102320	molecular_function	1,8-cineole 2-exo-monooxygenase activity

Functional Information from PROSITE/UniProt

site_id	PS00086
Number of Residues	10
Details	CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGsGPRNCIG

Chain	Residue	Details
A	PHE435-GLY444

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
A	ALA2-THR42

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: axial binding residue => ECO:0007744|PDB:1TQN, ECO:0007744|PDB:1W0G

Chain	Residue	Details
A	ASN462

---