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8EVJ

CX3CR1 nucleosome bound PU.1 and C/EBPa

Functional Information from GO Data
ChainGOidnamespacecontents
A0000786cellular_componentnucleosome
A0003677molecular_functionDNA binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005694cellular_componentchromosome
A0006325biological_processchromatin organization
A0006334biological_processnucleosome assembly
A0010467biological_processgene expression
A0016020cellular_componentmembrane
A0030527molecular_functionstructural constituent of chromatin
A0032200biological_processtelomere organization
A0032991cellular_componentprotein-containing complex
A0040029biological_processepigenetic regulation of gene expression
A0045296molecular_functioncadherin binding
A0046982molecular_functionprotein heterodimerization activity
A0070062cellular_componentextracellular exosome
B0000781cellular_componentchromosome, telomeric region
B0000786cellular_componentnucleosome
B0003677molecular_functionDNA binding
B0003723molecular_functionRNA binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005694cellular_componentchromosome
B0006325biological_processchromatin organization
B0006334biological_processnucleosome assembly
B0016020cellular_componentmembrane
B0030527molecular_functionstructural constituent of chromatin
B0032200biological_processtelomere organization
B0032991cellular_componentprotein-containing complex
B0043505cellular_componentCENP-A containing nucleosome
B0045653biological_processnegative regulation of megakaryocyte differentiation
B0046982molecular_functionprotein heterodimerization activity
B0061644biological_processprotein localization to CENP-A containing chromatin
B0070062cellular_componentextracellular exosome
C0000786cellular_componentnucleosome
C0003677molecular_functionDNA binding
C0005634cellular_componentnucleus
C0005694cellular_componentchromosome
C0030527molecular_functionstructural constituent of chromatin
C0031507biological_processheterochromatin formation
C0046982molecular_functionprotein heterodimerization activity
C0070062cellular_componentextracellular exosome
D0000786cellular_componentnucleosome
D0002227biological_processinnate immune response in mucosa
D0003677molecular_functionDNA binding
D0005515molecular_functionprotein binding
D0005615cellular_componentextracellular space
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005694cellular_componentchromosome
D0005829cellular_componentcytosol
D0006334biological_processnucleosome assembly
D0019731biological_processantibacterial humoral response
D0030527molecular_functionstructural constituent of chromatin
D0042742biological_processdefense response to bacterium
D0046982molecular_functionprotein heterodimerization activity
D0050830biological_processdefense response to Gram-positive bacterium
D0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
D0070062cellular_componentextracellular exosome
E0000786cellular_componentnucleosome
E0003677molecular_functionDNA binding
E0005515molecular_functionprotein binding
E0005576cellular_componentextracellular region
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005694cellular_componentchromosome
E0006325biological_processchromatin organization
E0006334biological_processnucleosome assembly
E0010467biological_processgene expression
E0016020cellular_componentmembrane
E0030527molecular_functionstructural constituent of chromatin
E0032200biological_processtelomere organization
E0032991cellular_componentprotein-containing complex
E0040029biological_processepigenetic regulation of gene expression
E0045296molecular_functioncadherin binding
E0046982molecular_functionprotein heterodimerization activity
E0070062cellular_componentextracellular exosome
F0000781cellular_componentchromosome, telomeric region
F0000786cellular_componentnucleosome
F0003677molecular_functionDNA binding
F0003723molecular_functionRNA binding
F0005515molecular_functionprotein binding
F0005576cellular_componentextracellular region
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005694cellular_componentchromosome
F0006325biological_processchromatin organization
F0006334biological_processnucleosome assembly
F0016020cellular_componentmembrane
F0030527molecular_functionstructural constituent of chromatin
F0032200biological_processtelomere organization
F0032991cellular_componentprotein-containing complex
F0043505cellular_componentCENP-A containing nucleosome
F0045653biological_processnegative regulation of megakaryocyte differentiation
F0046982molecular_functionprotein heterodimerization activity
F0061644biological_processprotein localization to CENP-A containing chromatin
F0070062cellular_componentextracellular exosome
G0000786cellular_componentnucleosome
G0003677molecular_functionDNA binding
G0005634cellular_componentnucleus
G0005694cellular_componentchromosome
G0030527molecular_functionstructural constituent of chromatin
G0031507biological_processheterochromatin formation
G0046982molecular_functionprotein heterodimerization activity
G0070062cellular_componentextracellular exosome
H0000786cellular_componentnucleosome
H0002227biological_processinnate immune response in mucosa
H0003677molecular_functionDNA binding
H0005515molecular_functionprotein binding
H0005615cellular_componentextracellular space
H0005634cellular_componentnucleus
H0005654cellular_componentnucleoplasm
H0005694cellular_componentchromosome
H0005829cellular_componentcytosol
H0006334biological_processnucleosome assembly
H0019731biological_processantibacterial humoral response
H0030527molecular_functionstructural constituent of chromatin
H0042742biological_processdefense response to bacterium
H0046982molecular_functionprotein heterodimerization activity
H0050830biological_processdefense response to Gram-positive bacterium
H0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
H0070062cellular_componentextracellular exosome
O0000122biological_processnegative regulation of transcription by RNA polymerase II
O0000785cellular_componentchromatin
O0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
O0000981molecular_functionDNA-binding transcription factor activity, RNA polymerase II-specific
O0000987molecular_functioncis-regulatory region sequence-specific DNA binding
O0001227molecular_functionDNA-binding transcription repressor activity, RNA polymerase II-specific
O0001228molecular_functionDNA-binding transcription activator activity, RNA polymerase II-specific
O0001944biological_processvasculature development
O0002314biological_processgerminal center B cell differentiation
O0002316biological_processfollicular B cell differentiation
O0002320biological_processlymphoid progenitor cell differentiation
O0002327biological_processimmature B cell differentiation
O0002572biological_processpro-T cell differentiation
O0002573biological_processmyeloid leukocyte differentiation
O0003677molecular_functionDNA binding
O0003682molecular_functionchromatin binding
O0003700molecular_functionDNA-binding transcription factor activity
O0003723molecular_functionRNA binding
O0005515molecular_functionprotein binding
O0005634cellular_componentnucleus
O0005654cellular_componentnucleoplasm
O0005667cellular_componenttranscription regulator complex
O0006355biological_processregulation of DNA-templated transcription
O0006357biological_processregulation of transcription by RNA polymerase II
O0007179biological_processtransforming growth factor beta receptor signaling pathway
O0010628biological_processpositive regulation of gene expression
O0010629biological_processnegative regulation of gene expression
O0030098biological_processlymphocyte differentiation
O0030218biological_processerythrocyte differentiation
O0030225biological_processmacrophage differentiation
O0030851biological_processgranulocyte differentiation
O0031663biological_processlipopolysaccharide-mediated signaling pathway
O0035019biological_processsomatic stem cell population maintenance
O0042826molecular_functionhistone deacetylase binding
O0043011biological_processmyeloid dendritic cell differentiation
O0043314biological_processnegative regulation of neutrophil degranulation
O0043565molecular_functionsequence-specific DNA binding
O0045347biological_processnegative regulation of MHC class II biosynthetic process
O0045579biological_processpositive regulation of B cell differentiation
O0045815biological_processtranscription initiation-coupled chromatin remodeling
O0045892biological_processnegative regulation of DNA-templated transcription
O0045893biological_processpositive regulation of DNA-templated transcription
O0045944biological_processpositive regulation of transcription by RNA polymerase II
O0051090biological_processregulation of DNA-binding transcription factor activity
O0051525molecular_functionNFAT protein binding
O0060033biological_processanatomical structure regression
O0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
O0090402biological_processoncogene-induced cell senescence
O0098508biological_processendothelial to hematopoietic transition
O0120186biological_processnegative regulation of protein localization to chromatin
O0140297molecular_functionDNA-binding transcription factor binding
O0140311molecular_functionprotein sequestering activity
O1900745biological_processpositive regulation of p38MAPK cascade
O1902262biological_processapoptotic process involved in blood vessel morphogenesis
O1902895biological_processpositive regulation of miRNA transcription
O1904151biological_processpositive regulation of microglial cell mediated cytotoxicity
O1904178biological_processnegative regulation of adipose tissue development
O1904238biological_processpericyte cell differentiation
O1905036biological_processpositive regulation of antifungal innate immune response
O1905453biological_processregulation of myeloid progenitor cell differentiation
O2000529biological_processpositive regulation of myeloid dendritic cell chemotaxis
Functional Information from PROSITE/UniProt
site_idPS00046
Number of Residues7
DetailsHISTONE_H2A Histone H2A signature. AGLqFPV
ChainResidueDetails
CALA21-VAL27

site_idPS00047
Number of Residues5
DetailsHISTONE_H4 Histone H4 signature. GAKRH
ChainResidueDetails
BGLY14-HIS18

site_idPS00322
Number of Residues7
DetailsHISTONE_H3_1 Histone H3 signature 1. KAPRKQL
ChainResidueDetails
ALYS14-LEU20

site_idPS00345
Number of Residues9
DetailsETS_DOMAIN_1 Ets-domain signature 1. LYQFLLDLL
ChainResidueDetails
OLEU174-LEU182

site_idPS00346
Number of Residues16
DetailsETS_DOMAIN_2 Ets-domain signature 2. RkkMtYQkMARALRnY
ChainResidueDetails
OARG222-TYR237

site_idPS00357
Number of Residues23
DetailsHISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG
ChainResidueDetails
DARG89-GLY111

site_idPS00959
Number of Residues9
DetailsHISTONE_H3_2 Histone H3 signature 2. PFqRLVREI
ChainResidueDetails
APRO66-ILE74

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues83
DetailsDNA_BIND: ETS => ECO:0000255|PROSITE-ProRule:PRU00237
ChainResidueDetails
OILE172-SER255
HPRO-2

site_idSWS_FT_FI2
Number of Residues1
DetailsBINDING: forms a salt bridge with the phosphate backbone of the opposite strand downstream of the GGAA core sequence => ECO:0000269|PubMed:8602247
ChainResidueDetails
OLYS219
HGLU-1

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: contacts bases in the GGAA sequence in the major groove => ECO:0000269|PubMed:8602247, ECO:0007744|PDB:1PUE
ChainResidueDetails
OARG232
HLYS8
HLYS12
HLYS13
HLYS17
HLYS20
HLYS40
HLYS82
OARG235
DLYS12
DLYS13
DLYS17
DLYS20
DLYS40
DLYS82
HLYS2

site_idSWS_FT_FI4
Number of Residues1
DetailsBINDING: contacts the phosphate backbone of the GGAA sequence in the minor groove upstream => ECO:0000269|PubMed:8602247
ChainResidueDetails
OLYS245
HSER3
GLYS9
GLYS95

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P17947
ChainResidueDetails
OSER142
HLYS9
BLYS44
FLYS8
FLYS16
FLYS44

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19144319
ChainResidueDetails
OSER148
HSER11
BLYS77
BLYS91
FLYS12
FLYS31
FLYS77
FLYS91

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: N6-(2-hydroxyisobutyryl)lysine => ECO:0000269|PubMed:24681537
ChainResidueDetails
DLYS21
HLYS21
GLYS74
GLYS75

site_idSWS_FT_FI8
Number of Residues6
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435
ChainResidueDetails
DLYS31
DLYS113
DLYS117
HLYS31
HLYS113
HLYS117

site_idSWS_FT_FI9
Number of Residues2
DetailsMOD_RES: PolyADP-ribosyl glutamic acid => ECO:0000250|UniProtKB:Q64475
ChainResidueDetails
DGLU32
HGLU32

site_idSWS_FT_FI10
Number of Residues2
DetailsMOD_RES: Phosphoserine; by AMPK => ECO:0000250|UniProtKB:Q64524
ChainResidueDetails
DSER33
HSER33
GLYS118
GLYS119

site_idSWS_FT_FI11
Number of Residues4
DetailsMOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:16627869
ChainResidueDetails
DLYS43
DLYS105
HLYS43
HLYS105

site_idSWS_FT_FI12
Number of Residues2
DetailsMOD_RES: N6-(2-hydroxyisobutyryl)lysine; alternate => ECO:0000269|PubMed:24681537
ChainResidueDetails
DLYS54
HLYS54
ELYS18
ELYS64

site_idSWS_FT_FI13
Number of Residues2
DetailsMOD_RES: Dimethylated arginine => ECO:0000250|UniProtKB:Q96A08
ChainResidueDetails
DARG76
HARG76

site_idSWS_FT_FI14
Number of Residues4
DetailsMOD_RES: Omega-N-methylarginine => ECO:0000250|UniProtKB:Q96A08
ChainResidueDetails
DARG83
DARG89
HARG83
HARG89

site_idSWS_FT_FI15
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q00729
ChainResidueDetails
DTHR112
HTHR112
GLYS119

site_idSWS_FT_FI16
Number of Residues2
DetailsCARBOHYD: O-linked (GlcNAc) serine => ECO:0000250|UniProtKB:P62807
ChainResidueDetails
DSER109
HSER109
BLYS79
FLYS20
FLYS59
FLYS79

site_idSWS_FT_FI17
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0000250|UniProtKB:P58876
ChainResidueDetails
DLYS2
HLYS2

site_idSWS_FT_FI18
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:16627869, ECO:0000269|PubMed:16713563
ChainResidueDetails
ALYS37
DLYS117
HLYS117

site_idSWS_FT_FI19
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0000250|UniProtKB:Q5QNW6
ChainResidueDetails
DLYS17
HLYS17

site_idSWS_FT_FI20
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:21726816
ChainResidueDetails
DLYS31
HLYS31

site_idSWS_FT_FI21
Number of Residues2
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435, ECO:0000269|PubMed:29211711
ChainResidueDetails
ALYS79
ELYS79

site_idSWS_FT_FI22
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0000269|PubMed:20850016
ChainResidueDetails
ATHR80
ETHR80

site_idSWS_FT_FI23
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P84243
ChainResidueDetails
ASER86
ESER86

site_idSWS_FT_FI24
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q71DI3
ChainResidueDetails
ATHR107
ETHR107

site_idSWS_FT_FI25
Number of Residues2
DetailsMOD_RES: N6-glutaryllysine; alternate => ECO:0000269|PubMed:31542297
ChainResidueDetails
ALYS115
ELYS115

site_idSWS_FT_FI26
Number of Residues2
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435, ECO:0000269|PubMed:27436229
ChainResidueDetails
ALYS122
ELYS122

site_idSWS_FT_FI27
Number of Residues2
DetailsLIPID: N6-decanoyllysine => ECO:0000269|PubMed:35939806
ChainResidueDetails
ALYS18
ELYS18

227111

PDB entries from 2024-11-06

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