8ESC
Structure of the Yeast NuA4 Histone Acetyltransferase Complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000011 | biological_process | vacuole inheritance |
| A | 0000142 | cellular_component | cellular bud neck contractile ring |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000785 | cellular_component | chromatin |
| A | 0000812 | cellular_component | Swr1 complex |
| A | 0005200 | molecular_function | structural constituent of cytoskeleton |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005856 | cellular_component | cytoskeleton |
| A | 0005884 | cellular_component | actin filament |
| A | 0006281 | biological_process | DNA repair |
| A | 0006338 | biological_process | chromatin remodeling |
| A | 0006351 | biological_process | DNA-templated transcription |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0006897 | biological_process | endocytosis |
| A | 0009306 | biological_process | protein secretion |
| A | 0015629 | cellular_component | actin cytoskeleton |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0030010 | biological_process | establishment of cell polarity |
| A | 0030476 | biological_process | ascospore wall assembly |
| A | 0030479 | cellular_component | actin cortical patch |
| A | 0031011 | cellular_component | Ino80 complex |
| A | 0032432 | cellular_component | actin filament bundle |
| A | 0035267 | cellular_component | NuA4 histone acetyltransferase complex |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0071944 | cellular_component | cell periphery |
| A | 1902404 | biological_process | mitotic actomyosin contractile ring contraction |
| E | 0003674 | molecular_function | molecular_function |
| E | 0003682 | molecular_function | chromatin binding |
| E | 0005515 | molecular_function | protein binding |
| E | 0005634 | cellular_component | nucleus |
| E | 0006281 | biological_process | DNA repair |
| E | 0006325 | biological_process | chromatin organization |
| E | 0006351 | biological_process | DNA-templated transcription |
| E | 0006974 | biological_process | DNA damage response |
| E | 0035267 | cellular_component | NuA4 histone acetyltransferase complex |
| E | 0065003 | biological_process | protein-containing complex assembly |
| P | 0000786 | cellular_component | nucleosome |
| P | 0004402 | molecular_function | histone acetyltransferase activity |
| P | 0005515 | molecular_function | protein binding |
| P | 0005634 | cellular_component | nucleus |
| P | 0006281 | biological_process | DNA repair |
| P | 0006338 | biological_process | chromatin remodeling |
| P | 0006351 | biological_process | DNA-templated transcription |
| P | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
| P | 0006974 | biological_process | DNA damage response |
| P | 0016239 | biological_process | positive regulation of macroautophagy |
| P | 0032777 | cellular_component | piccolo histone acetyltransferase complex |
| P | 0035267 | cellular_component | NuA4 histone acetyltransferase complex |
| R | 0000785 | cellular_component | chromatin |
| R | 0000812 | cellular_component | Swr1 complex |
| R | 0003682 | molecular_function | chromatin binding |
| R | 0005515 | molecular_function | protein binding |
| R | 0005524 | molecular_function | ATP binding |
| R | 0005634 | cellular_component | nucleus |
| R | 0006281 | biological_process | DNA repair |
| R | 0006325 | biological_process | chromatin organization |
| R | 0006338 | biological_process | chromatin remodeling |
| R | 0006351 | biological_process | DNA-templated transcription |
| R | 0006355 | biological_process | regulation of DNA-templated transcription |
| R | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
| R | 0006974 | biological_process | DNA damage response |
| R | 0010468 | biological_process | regulation of gene expression |
| R | 0016514 | cellular_component | SWI/SNF complex |
| R | 0031011 | cellular_component | Ino80 complex |
| R | 0035267 | cellular_component | NuA4 histone acetyltransferase complex |
| R | 0042393 | molecular_function | histone binding |
| R | 0051382 | biological_process | kinetochore assembly |
| S | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| S | 0000785 | cellular_component | chromatin |
| S | 0000812 | cellular_component | Swr1 complex |
| S | 0003714 | molecular_function | transcription corepressor activity |
| S | 0005515 | molecular_function | protein binding |
| S | 0005634 | cellular_component | nucleus |
| S | 0005694 | cellular_component | chromosome |
| S | 0006281 | biological_process | DNA repair |
| S | 0006325 | biological_process | chromatin organization |
| S | 0006338 | biological_process | chromatin remodeling |
| S | 0006351 | biological_process | DNA-templated transcription |
| S | 0006355 | biological_process | regulation of DNA-templated transcription |
| S | 0006974 | biological_process | DNA damage response |
| S | 0035267 | cellular_component | NuA4 histone acetyltransferase complex |
| S | 0051276 | biological_process | chromosome organization |
| Z | 0000124 | cellular_component | SAGA complex |
| Z | 0004402 | molecular_function | histone acetyltransferase activity |
| Z | 0004672 | molecular_function | protein kinase activity |
| Z | 0005515 | molecular_function | protein binding |
| Z | 0005634 | cellular_component | nucleus |
| Z | 0006281 | biological_process | DNA repair |
| Z | 0006325 | biological_process | chromatin organization |
| Z | 0006351 | biological_process | DNA-templated transcription |
| Z | 0006355 | biological_process | regulation of DNA-templated transcription |
| Z | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
| Z | 0033554 | biological_process | cellular response to stress |
| Z | 0035267 | cellular_component | NuA4 histone acetyltransferase complex |
| Z | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| Z | 0046695 | cellular_component | SLIK (SAGA-like) complex |
| Z | 0110078 | cellular_component | TTT Hsp90 cochaperone complex |
| Z | 0140861 | biological_process | DNA repair-dependent chromatin remodeling |
Functional Information from PROSITE/UniProt
| site_id | PS00406 |
| Number of Residues | 11 |
| Details | ACTINS_1 Actins signature 1. YVGDEAQs.KRG |
| Chain | Residue | Details |
| A | TYR53-GLY63 |
| site_id | PS00432 |
| Number of Residues | 9 |
| Details | ACTINS_2 Actins signature 2. WISKqEYDE |
| Chain | Residue | Details |
| A | TRP356-GLU364 |
| site_id | PS01132 |
| Number of Residues | 13 |
| Details | ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEPvWNSteNR |
| Chain | Residue | Details |
| R | LEU109-ARG121 | |
| A | LEU104-ARG116 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 38 |
| Details | Repeat: {"description":"HEAT 1","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 46 |
| Details | Repeat: {"description":"HEAT 2","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 3","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 5","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 38 |
| Details | Repeat: {"description":"HEAT 6","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 40 |
| Details | Repeat: {"description":"HEAT 7","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 40 |
| Details | Repeat: {"description":"HEAT 8","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 9","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 42 |
| Details | Repeat: {"description":"HEAT 10","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 38 |
| Details | Repeat: {"description":"HEAT 11","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 40 |
| Details | Repeat: {"description":"HEAT 12","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"HEAT 13","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 38 |
| Details | Repeat: {"description":"HEAT 14","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 15","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 16","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 18","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 36 |
| Details | Repeat: {"description":"HEAT 19","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 41 |
| Details | Repeat: {"description":"HEAT 20","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 21","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI20 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 22","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI21 |
| Number of Residues | 40 |
| Details | Repeat: {"description":"HEAT 23","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI22 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 24","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI23 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 25","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI24 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 27","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI25 |
| Number of Residues | 358 |
| Details | Domain: {"description":"PI3K/PI4K catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI26 |
| Number of Residues | 32 |
| Details | Domain: {"description":"FATC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00534","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU00535","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI27 |
| Number of Residues | 6 |
| Details | Region: {"description":"G-loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI28 |
| Number of Residues | 8 |
| Details | Region: {"description":"Catalytic loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI29 |
| Number of Residues | 25 |
| Details | Region: {"description":"Activation loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI30 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI31 |
| Number of Residues | 1 |
| Details | Site: {"description":"Not methylated","evidences":[{"source":"PubMed","id":"10496983","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI32 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22106047","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI33 |
| Number of Residues | 62 |
| Details | Domain: {"description":"Myb-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00133","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
