8ERL

CryoEM Structure of Lipoprotein Lipase Dimer

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004465	molecular_function	lipoprotein lipase activity
A	0006629	biological_process	lipid metabolic process
A	0016298	molecular_function	lipase activity
A	0052689	molecular_function	carboxylic ester hydrolase activity
B	0004465	molecular_function	lipoprotein lipase activity
B	0006629	biological_process	lipid metabolic process
B	0016298	molecular_function	lipase activity
B	0052689	molecular_function	carboxylic ester hydrolase activity

Functional Information from PROSITE/UniProt

site_id	PS00120
Number of Residues	10
Details	LIPASE_SER Lipases, serine active site. VHLLGYSLGA

Chain	Residue	Details
A	VAL156-ALA165

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Nucleophile => ECO:0000250|UniProtKB:P06858

Chain	Residue	Details
A	SER162
B	SER162

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site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: Charge relay system => ECO:0000255|PROSITE-ProRule:PRU10037

Chain	Residue	Details
A	ASP186
A	HIS271
B	ASP186
B	HIS271

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site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P06858

Chain	Residue	Details
A	ALA197
A	ARG200
A	SER202
A	ASP205
B	ALA197
B	ARG200
B	SER202
B	ASP205

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site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: 3'-nitrotyrosine => ECO:0000250|UniProtKB:Q06000

Chain	Residue	Details
A	TYR124
A	TYR194
A	TYR346
B	TYR124
B	TYR194
B	TYR346

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site_id	SWS_FT_FI5
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:2674142

Chain	Residue	Details
A	ASN73
A	ASN389
B	ASN73
B	ASN389

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site_id	SWS_FT_FI6
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN287
B	ASN287

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