8ER6

FKBP12-FRB in Complex with Compound 11

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000413	biological_process	protein peptidyl-prolyl isomerization
A	0003007	biological_process	heart morphogenesis
A	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
A	0005160	molecular_function	transforming growth factor beta receptor binding
A	0005515	molecular_function	protein binding
A	0005527	molecular_function	macrolide binding
A	0005528	molecular_function	FK506 binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006457	biological_process	protein folding
A	0006458	biological_process	'de novo' protein folding
A	0014802	cellular_component	terminal cisterna
A	0014809	biological_process	regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
A	0016020	cellular_component	membrane
A	0016247	molecular_function	channel regulator activity
A	0016529	cellular_component	sarcoplasmic reticulum
A	0022417	biological_process	protein maturation by protein folding
A	0030018	cellular_component	Z disc
A	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
A	0030547	molecular_function	signaling receptor inhibitor activity
A	0032092	biological_process	positive regulation of protein binding
A	0032880	biological_process	regulation of protein localization
A	0032926	biological_process	negative regulation of activin receptor signaling pathway
A	0033017	cellular_component	sarcoplasmic reticulum membrane
A	0034713	molecular_function	type I transforming growth factor beta receptor binding
A	0042026	biological_process	protein refolding
A	0042110	biological_process	T cell activation
A	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
A	0044325	molecular_function	transmembrane transporter binding
A	0050776	biological_process	regulation of immune response
A	0055010	biological_process	ventricular cardiac muscle tissue morphogenesis
A	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
A	0060347	biological_process	heart trabecula formation
A	0070411	molecular_function	I-SMAD binding
A	0070588	biological_process	calcium ion transmembrane transport
A	0070697	molecular_function	activin receptor binding
A	0097435	biological_process	supramolecular fiber organization
A	0098562	cellular_component	cytoplasmic side of membrane
A	1902991	biological_process	regulation of amyloid precursor protein catabolic process
A	1990000	biological_process	amyloid fibril formation
A	1990425	cellular_component	ryanodine receptor complex
B	0044877	molecular_function	protein-containing complex binding
C	0000413	biological_process	protein peptidyl-prolyl isomerization
C	0003007	biological_process	heart morphogenesis
C	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
C	0005160	molecular_function	transforming growth factor beta receptor binding
C	0005515	molecular_function	protein binding
C	0005527	molecular_function	macrolide binding
C	0005528	molecular_function	FK506 binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006457	biological_process	protein folding
C	0006458	biological_process	'de novo' protein folding
C	0014802	cellular_component	terminal cisterna
C	0014809	biological_process	regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
C	0016020	cellular_component	membrane
C	0016247	molecular_function	channel regulator activity
C	0016529	cellular_component	sarcoplasmic reticulum
C	0022417	biological_process	protein maturation by protein folding
C	0030018	cellular_component	Z disc
C	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
C	0030547	molecular_function	signaling receptor inhibitor activity
C	0032092	biological_process	positive regulation of protein binding
C	0032880	biological_process	regulation of protein localization
C	0032926	biological_process	negative regulation of activin receptor signaling pathway
C	0033017	cellular_component	sarcoplasmic reticulum membrane
C	0034713	molecular_function	type I transforming growth factor beta receptor binding
C	0042026	biological_process	protein refolding
C	0042110	biological_process	T cell activation
C	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
C	0044325	molecular_function	transmembrane transporter binding
C	0050776	biological_process	regulation of immune response
C	0055010	biological_process	ventricular cardiac muscle tissue morphogenesis
C	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
C	0060347	biological_process	heart trabecula formation
C	0070411	molecular_function	I-SMAD binding
C	0070588	biological_process	calcium ion transmembrane transport
C	0070697	molecular_function	activin receptor binding
C	0097435	biological_process	supramolecular fiber organization
C	0098562	cellular_component	cytoplasmic side of membrane
C	1902991	biological_process	regulation of amyloid precursor protein catabolic process
C	1990000	biological_process	amyloid fibril formation
C	1990425	cellular_component	ryanodine receptor complex
D	0044877	molecular_function	protein-containing complex binding
E	0000413	biological_process	protein peptidyl-prolyl isomerization
E	0003007	biological_process	heart morphogenesis
E	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
E	0005160	molecular_function	transforming growth factor beta receptor binding
E	0005515	molecular_function	protein binding
E	0005527	molecular_function	macrolide binding
E	0005528	molecular_function	FK506 binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006457	biological_process	protein folding
E	0006458	biological_process	'de novo' protein folding
E	0014802	cellular_component	terminal cisterna
E	0014809	biological_process	regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
E	0016020	cellular_component	membrane
E	0016247	molecular_function	channel regulator activity
E	0016529	cellular_component	sarcoplasmic reticulum
E	0022417	biological_process	protein maturation by protein folding
E	0030018	cellular_component	Z disc
E	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
E	0030547	molecular_function	signaling receptor inhibitor activity
E	0032092	biological_process	positive regulation of protein binding
E	0032880	biological_process	regulation of protein localization
E	0032926	biological_process	negative regulation of activin receptor signaling pathway
E	0033017	cellular_component	sarcoplasmic reticulum membrane
E	0034713	molecular_function	type I transforming growth factor beta receptor binding
E	0042026	biological_process	protein refolding
E	0042110	biological_process	T cell activation
E	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
E	0044325	molecular_function	transmembrane transporter binding
E	0050776	biological_process	regulation of immune response
E	0055010	biological_process	ventricular cardiac muscle tissue morphogenesis
E	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
E	0060347	biological_process	heart trabecula formation
E	0070411	molecular_function	I-SMAD binding
E	0070588	biological_process	calcium ion transmembrane transport
E	0070697	molecular_function	activin receptor binding
E	0097435	biological_process	supramolecular fiber organization
E	0098562	cellular_component	cytoplasmic side of membrane
E	1902991	biological_process	regulation of amyloid precursor protein catabolic process
E	1990000	biological_process	amyloid fibril formation
E	1990425	cellular_component	ryanodine receptor complex
F	0044877	molecular_function	protein-containing complex binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P26883

Chain	Residue	Details
A	LYS53
C	LYS53
E	LYS53

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	6
Details	M-CSA 362

Chain	Residue	Details
A	TYR27	electrostatic destabiliser, steric role
A	PHE37	electrostatic destabiliser, polar/non-polar interaction, steric role
A	ASP38	electrostatic stabiliser, steric role
A	ILE57	electrostatic stabiliser, steric role
A	TYR83	electrostatic stabiliser, steric role
A	PHE100	electrostatic destabiliser, polar/non-polar interaction, steric role

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site_id	MCSA2
Number of Residues	6
Details	M-CSA 362

Chain	Residue	Details
C	TYR27	electrostatic destabiliser, steric role
C	PHE37	electrostatic destabiliser, polar/non-polar interaction, steric role
C	ASP38	electrostatic stabiliser, steric role
C	ILE57	electrostatic stabiliser, steric role
C	TYR83	electrostatic stabiliser, steric role
C	PHE100	electrostatic destabiliser, polar/non-polar interaction, steric role

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site_id	MCSA3
Number of Residues	6
Details	M-CSA 362

Chain	Residue	Details
E	TYR27	electrostatic destabiliser, steric role
E	PHE37	electrostatic destabiliser, polar/non-polar interaction, steric role
E	ASP38	electrostatic stabiliser, steric role
E	ILE57	electrostatic stabiliser, steric role
E	TYR83	electrostatic stabiliser, steric role
E	PHE100	electrostatic destabiliser, polar/non-polar interaction, steric role

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