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8EQJ

Structure of SARS-CoV-2 Orf3a in late endosome/lysosome-like membrane environment, MSP1D1 nanodisc

Functional Information from GO Data
ChainGOidnamespacecontents
A0005216molecular_functionmonoatomic ion channel activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005886cellular_componentplasma membrane
A0005891cellular_componentvoltage-gated calcium channel complex
A0008076cellular_componentvoltage-gated potassium channel complex
A0009898cellular_componentcytoplasmic side of plasma membrane
A0016020cellular_componentmembrane
A0020002cellular_componenthost cell plasma membrane
A0030430cellular_componenthost cell cytoplasm
A0034220biological_processmonoatomic ion transmembrane transport
A0039520biological_processinduction by virus of host autophagy
A0042802molecular_functionidentical protein binding
A0044165cellular_componenthost cell endoplasmic reticulum
A0044167cellular_componenthost cell endoplasmic reticulum membrane
A0044174cellular_componenthost cell endosome
A0044187cellular_componenthost cell lysosome
A0044423cellular_componentvirion component
A0051259biological_processprotein complex oligomerization
A0055036cellular_componentvirion membrane
A0098662biological_processinorganic cation transmembrane transport
A0140677molecular_functionmolecular function activator activity
A0140883biological_processinduction by virus of host reticulophagy
B0005216molecular_functionmonoatomic ion channel activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005886cellular_componentplasma membrane
B0005891cellular_componentvoltage-gated calcium channel complex
B0008076cellular_componentvoltage-gated potassium channel complex
B0009898cellular_componentcytoplasmic side of plasma membrane
B0016020cellular_componentmembrane
B0020002cellular_componenthost cell plasma membrane
B0030430cellular_componenthost cell cytoplasm
B0034220biological_processmonoatomic ion transmembrane transport
B0039520biological_processinduction by virus of host autophagy
B0042802molecular_functionidentical protein binding
B0044165cellular_componenthost cell endoplasmic reticulum
B0044167cellular_componenthost cell endoplasmic reticulum membrane
B0044174cellular_componenthost cell endosome
B0044187cellular_componenthost cell lysosome
B0044423cellular_componentvirion component
B0051259biological_processprotein complex oligomerization
B0055036cellular_componentvirion membrane
B0098662biological_processinorganic cation transmembrane transport
B0140677molecular_functionmolecular function activator activity
B0140883biological_processinduction by virus of host reticulophagy
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues96
DetailsTOPO_DOM: Extracellular => ECO:0000269|PubMed:34158638
ChainResidueDetails
AMET1-PRO42
ALEU94-LEU101
BMET1-PRO42
BLEU94-LEU101

site_idSWS_FT_FI2
Number of Residues134
DetailsTRANSMEM: Helical => ECO:0000269|PubMed:34158638
ChainResidueDetails
APHE43-LYS61
AARG68-HIS93
AGLU102-ARG126
BPHE43-LYS61
BARG68-HIS93
BGLU102-ARG126

site_idSWS_FT_FI3
Number of Residues306
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:34158638
ChainResidueDetails
AILE62-LYS67
ALEU127-LEU275
BILE62-LYS67
BLEU127-LEU275

site_idSWS_FT_FI4
Number of Residues2
DetailsSITE: Involved in polymerization => ECO:0000250|UniProtKB:P59632
ChainResidueDetails
ACYS133
BCYS133

site_idSWS_FT_FI5
Number of Residues2
DetailsCARBOHYD: O-linked (GalNAc...) threonine; by host => ECO:0000250|UniProtKB:P59632
ChainResidueDetails
ATHR32
BTHR32

site_idSWS_FT_FI6
Number of Residues2
DetailsCARBOHYD: O-linked (GalNAc...) threonine; by host => ECO:0000255
ChainResidueDetails
ATHR34
BTHR34

221371

PDB entries from 2024-06-19

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