8EPM
Human R-type voltage-gated calcium channel Cav2.3 CH2II-deleted mutant at 3.1 Angstrom resolution
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005216 | molecular_function | monoatomic ion channel activity |
A | 0005245 | molecular_function | voltage-gated calcium channel activity |
A | 0005262 | molecular_function | calcium channel activity |
A | 0005509 | molecular_function | calcium ion binding |
A | 0005886 | cellular_component | plasma membrane |
A | 0005891 | cellular_component | voltage-gated calcium channel complex |
A | 0006811 | biological_process | monoatomic ion transport |
A | 0006816 | biological_process | calcium ion transport |
A | 0007268 | biological_process | chemical synaptic transmission |
A | 0008331 | molecular_function | high voltage-gated calcium channel activity |
A | 0016020 | cellular_component | membrane |
A | 0022843 | molecular_function | voltage-gated monoatomic cation channel activity |
A | 0034702 | cellular_component | monoatomic ion channel complex |
A | 0043025 | cellular_component | neuronal cell body |
A | 0045202 | cellular_component | synapse |
A | 0046872 | molecular_function | metal ion binding |
A | 0055085 | biological_process | transmembrane transport |
A | 0070588 | biological_process | calcium ion transmembrane transport |
A | 0098703 | biological_process | calcium ion import across plasma membrane |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1048 |
Details | TOPO_DOM: Extracellular => ECO:0000255 |
Chain | Residue | Details |
C | GLU25-GLY1073 | |
A | ILE1423-SER1479 | |
A | PHE1534-THR1541 | |
A | TYR1591-TYR1609 | |
A | ASN1725-CYS2313 | |
A | GLY147-ASN158 | |
A | SER206-GLN223 | |
A | SER351-GLN476 | |
A | MET530-SER538 | |
A | ALA587-SER605 | |
A | ASP704-TYR1148 | |
A | LEU1210-TYR1217 | |
A | PRO1273-ASN1291 |
site_id | SWS_FT_FI2 |
Number of Residues | 20 |
Details | TRANSMEM: Helical => ECO:0000255 |
Chain | Residue | Details |
C | VAL1074-LEU1094 |
site_id | SWS_FT_FI3 |
Number of Residues | 8 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
Chain | Residue | Details |
C | VAL1095-LEU1103 | |
A | TYR1499-LEU1513 | |
A | ASP1561-ASN1571 | |
A | GLY1630-LEU1698 | |
A | ALA174-ASP185 | |
A | GLY245-TRP326 | |
A | HIS497-TYR509 | |
A | ALA558-GLY567 | |
A | GLY626-TRP678 | |
A | SER1166-PHE1189 | |
A | ASN1241-ILE1254 | |
A | LYS1312-GLU1398 |
site_id | SWS_FT_FI4 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
C | ASP259 | |
C | SER261 | |
C | SER263 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P54290 |
Chain | Residue | Details |
C | SER119 |
site_id | SWS_FT_FI6 |
Number of Residues | 7 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:34234349, ECO:0007744|PDB:7MIX, ECO:0007744|PDB:7MIY |
Chain | Residue | Details |
C | ASN92 | |
C | ASN184 | |
C | ASN348 | |
C | ASN468 | |
C | ASN613 | |
C | ASN781 | |
C | ASN895 |
site_id | SWS_FT_FI7 |
Number of Residues | 9 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
Chain | Residue | Details |
C | ASN136 | |
C | ASN324 | |
C | ASN475 | |
C | ASN604 | |
C | ASN675 | |
C | ASN824 | |
C | ASN888 | |
C | ASN985 | |
C | ASN998 |
site_id | SWS_FT_FI8 |
Number of Residues | 23 |
Details | TRANSMEM: Helical; Name=S6 of repeat I |
Chain | Residue | Details |
A | ASN327-LEU350 |
site_id | SWS_FT_FI9 |
Number of Residues | 19 |
Details | TRANSMEM: Helical; Name=S1 of repeat II |
Chain | Residue | Details |
A | VAL477-VAL496 |
site_id | SWS_FT_FI10 |
Number of Residues | 19 |
Details | TRANSMEM: Helical; Name=S2 of repeat II |
Chain | Residue | Details |
A | TYR510-GLY529 |
site_id | SWS_FT_FI11 |
Number of Residues | 18 |
Details | TRANSMEM: Helical; Name=S3 of repeat II |
Chain | Residue | Details |
A | SER539-TRP557 |
site_id | SWS_FT_FI12 |
Number of Residues | 18 |
Details | TRANSMEM: Helical; Name=S4 of repeat II |
Chain | Residue | Details |
A | ILE568-TRP586 |
site_id | SWS_FT_FI13 |
Number of Residues | 19 |
Details | TRANSMEM: Helical; Name=S5 of repeat II |
Chain | Residue | Details |
A | LEU606-PHE625 |
site_id | SWS_FT_FI14 |
Number of Residues | 24 |
Details | TRANSMEM: Helical; Name=S6 of repeat II |
Chain | Residue | Details |
A | SER679-VAL703 |
site_id | SWS_FT_FI15 |
Number of Residues | 16 |
Details | TRANSMEM: Helical; Name=S1 of repeat III |
Chain | Residue | Details |
A | ILE1149-ALA1165 |
site_id | SWS_FT_FI16 |
Number of Residues | 19 |
Details | TRANSMEM: Helical; Name=S2 of repeat III |
Chain | Residue | Details |
A | ASP1190-GLY1209 |
site_id | SWS_FT_FI17 |
Number of Residues | 22 |
Details | TRANSMEM: Helical; Name=S3 of repeat III |
Chain | Residue | Details |
A | PHE1218-ALA1240 |
site_id | SWS_FT_FI18 |
Number of Residues | 17 |
Details | TRANSMEM: Helical; Name=S4 of repeat III |
Chain | Residue | Details |
A | LYS1255-LEU1272 |
site_id | SWS_FT_FI19 |
Number of Residues | 19 |
Details | TRANSMEM: Helical; Name=S5 of repeat III |
Chain | Residue | Details |
A | ILE1292-PHE1311 |
site_id | SWS_FT_FI20 |
Number of Residues | 23 |
Details | TRANSMEM: Helical; Name=S6 of repeat III |
Chain | Residue | Details |
A | MET1399-ILE1422 |
site_id | SWS_FT_FI21 |
Number of Residues | 18 |
Details | TRANSMEM: Helical; Name=S1 of repeat IV |
Chain | Residue | Details |
A | PHE1480-LYS1498 |
site_id | SWS_FT_FI22 |
Number of Residues | 19 |
Details | TRANSMEM: Helical; Name=S2 of repeat IV |
Chain | Residue | Details |
A | ASN1514-GLY1533 |
site_id | SWS_FT_FI23 |
Number of Residues | 18 |
Details | TRANSMEM: Helical; Name=S3 of repeat IV |
Chain | Residue | Details |
A | TRP1542-THR1560 |
site_id | SWS_FT_FI24 |
Number of Residues | 18 |
Details | TRANSMEM: Helical; Name=S4 of repeat IV |
Chain | Residue | Details |
A | MET1572-GLY1590 |
site_id | SWS_FT_FI25 |
Number of Residues | 19 |
Details | TRANSMEM: Helical; Name=S5 of repeat IV |
Chain | Residue | Details |
A | VAL1610-PHE1629 |
site_id | SWS_FT_FI26 |
Number of Residues | 25 |
Details | TRANSMEM: Helical; Name=S6 of repeat IV |
Chain | Residue | Details |
A | ALA1699-ASP1724 |
site_id | SWS_FT_FI27 |
Number of Residues | 7 |
Details | BINDING: BINDING => ECO:0000305 |
Chain | Residue | Details |
A | ASP426 | |
A | SER428 | |
A | GLU430 | |
A | CYS432 | |
A | ASP1752 | |
A | ARG1758 | |
A | GLU1763 |
site_id | SWS_FT_FI28 |
Number of Residues | 4 |
Details | SITE: Calcium ion selectivity and permeability => ECO:0000250 |
Chain | Residue | Details |
A | GLU309 | |
A | GLU657 | |
A | GLU1372 | |
A | GLU1663 |
site_id | SWS_FT_FI29 |
Number of Residues | 7 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q61290 |
Chain | Residue | Details |
A | SER14 | |
A | SER19 | |
A | SER427 | |
A | SER745 | |
A | SER815 | |
A | SER855 | |
A | SER2094 |
site_id | SWS_FT_FI30 |
Number of Residues | 1 |
Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q61290 |
Chain | Residue | Details |
A | THR440 |
site_id | SWS_FT_FI31 |
Number of Residues | 5 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q07652 |
Chain | Residue | Details |
A | SER736 | |
A | SER793 | |
A | SER947 | |
A | SER1097 | |
A | SER2113 |
site_id | SWS_FT_FI32 |
Number of Residues | 3 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
Chain | Residue | Details |
A | ASN254 | |
A | ASN1566 | |
A | ASN1571 |