8EPL
Human R-type voltage-gated calcium channel Cav2.3 at 3.1 Angstrom resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005245 | molecular_function | voltage-gated calcium channel activity |
| A | 0005262 | molecular_function | calcium channel activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005891 | cellular_component | voltage-gated calcium channel complex |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006816 | biological_process | calcium ion transport |
| A | 0007268 | biological_process | chemical synaptic transmission |
| A | 0008331 | molecular_function | high voltage-gated calcium channel activity |
| A | 0016020 | cellular_component | membrane |
| A | 0022843 | molecular_function | voltage-gated monoatomic cation channel activity |
| A | 0034702 | cellular_component | monoatomic ion channel complex |
| A | 0043025 | cellular_component | neuronal cell body |
| A | 0045202 | cellular_component | synapse |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0070588 | biological_process | calcium ion transmembrane transport |
| A | 0098703 | biological_process | calcium ion import across plasma membrane |
| B | 0005245 | molecular_function | voltage-gated calcium channel activity |
| B | 0005246 | molecular_function | calcium channel regulator activity |
| B | 0005262 | molecular_function | calcium channel activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005891 | cellular_component | voltage-gated calcium channel complex |
| B | 0006816 | biological_process | calcium ion transport |
| B | 0007268 | biological_process | chemical synaptic transmission |
| B | 0007528 | biological_process | neuromuscular junction development |
| B | 0008331 | molecular_function | high voltage-gated calcium channel activity |
| B | 0016020 | cellular_component | membrane |
| B | 0034702 | cellular_component | monoatomic ion channel complex |
| B | 0045202 | cellular_component | synapse |
| B | 0050852 | biological_process | T cell receptor signaling pathway |
| B | 0060402 | biological_process | calcium ion transport into cytosol |
| B | 0061577 | biological_process | calcium ion transmembrane transport via high voltage-gated calcium channel |
| B | 0070588 | biological_process | calcium ion transmembrane transport |
| B | 0072659 | biological_process | protein localization to plasma membrane |
| B | 0098903 | biological_process | regulation of membrane repolarization during action potential |
| B | 1901843 | biological_process | positive regulation of high voltage-gated calcium channel activity |
| B | 1990454 | cellular_component | L-type voltage-gated calcium channel complex |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1048 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| C | GLU25-GLY1073 | |
| A | ILE1423-SER1479 | |
| A | PHE1534-THR1541 | |
| A | TYR1591-TYR1609 | |
| A | ASN1725-CYS2313 | |
| B | SER393 | |
| A | SER206-GLN223 | |
| A | SER351-GLN476 | |
| A | MET530-SER538 | |
| A | ALA587-SER605 | |
| A | ASP704-TYR1148 | |
| A | LEU1210-TYR1217 | |
| A | PRO1273-ASN1291 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| C | VAL1074-LEU1094 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| C | VAL1095-LEU1103 | |
| A | TYR1499-LEU1513 | |
| A | ASP1561-ASN1571 | |
| A | GLY1630-LEU1698 | |
| A | ALA174-ASP185 | |
| A | GLY245-TRP326 | |
| A | HIS497-TYR509 | |
| A | ALA558-GLY567 | |
| A | GLY626-TRP678 | |
| A | SER1166-PHE1189 | |
| A | ASN1241-ILE1254 | |
| A | LYS1312-GLU1398 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| C | ASP259 | |
| C | SER261 | |
| C | SER263 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P54290 |
| Chain | Residue | Details |
| C | SER119 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 7 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:34234349, ECO:0007744|PDB:7MIX, ECO:0007744|PDB:7MIY |
| Chain | Residue | Details |
| C | ASN92 | |
| C | ASN184 | |
| C | ASN348 | |
| C | ASN468 | |
| C | ASN613 | |
| C | ASN781 | |
| C | ASN895 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 9 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| C | ASN136 | |
| C | ASN324 | |
| C | ASN475 | |
| C | ASN604 | |
| C | ASN675 | |
| C | ASN824 | |
| C | ASN888 | |
| C | ASN985 | |
| C | ASN998 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=S6 of repeat I |
| Chain | Residue | Details |
| A | ASN327-LEU350 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S1 of repeat II |
| Chain | Residue | Details |
| A | VAL477-VAL496 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S2 of repeat II |
| Chain | Residue | Details |
| A | TYR510-GLY529 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S3 of repeat II |
| Chain | Residue | Details |
| A | SER539-TRP557 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S4 of repeat II |
| Chain | Residue | Details |
| A | ILE568-TRP586 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S5 of repeat II |
| Chain | Residue | Details |
| A | LEU606-PHE625 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=S6 of repeat II |
| Chain | Residue | Details |
| A | SER679-VAL703 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 16 |
| Details | TRANSMEM: Helical; Name=S1 of repeat III |
| Chain | Residue | Details |
| A | ILE1149-ALA1165 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S2 of repeat III |
| Chain | Residue | Details |
| A | ASP1190-GLY1209 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=S3 of repeat III |
| Chain | Residue | Details |
| A | PHE1218-ALA1240 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=S4 of repeat III |
| Chain | Residue | Details |
| A | LYS1255-LEU1272 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S5 of repeat III |
| Chain | Residue | Details |
| A | ILE1292-PHE1311 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=S6 of repeat III |
| Chain | Residue | Details |
| A | MET1399-ILE1422 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S1 of repeat IV |
| Chain | Residue | Details |
| A | PHE1480-LYS1498 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S2 of repeat IV |
| Chain | Residue | Details |
| A | ASN1514-GLY1533 |
| site_id | SWS_FT_FI23 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S3 of repeat IV |
| Chain | Residue | Details |
| A | TRP1542-THR1560 |
| site_id | SWS_FT_FI24 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S4 of repeat IV |
| Chain | Residue | Details |
| A | MET1572-GLY1590 |
| site_id | SWS_FT_FI25 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S5 of repeat IV |
| Chain | Residue | Details |
| A | VAL1610-PHE1629 |
| site_id | SWS_FT_FI26 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical; Name=S6 of repeat IV |
| Chain | Residue | Details |
| A | ALA1699-ASP1724 |
| site_id | SWS_FT_FI27 |
| Number of Residues | 7 |
| Details | BINDING: BINDING => ECO:0000305 |
| Chain | Residue | Details |
| A | ASP426 | |
| A | SER428 | |
| A | GLU430 | |
| A | CYS432 | |
| A | ASP1752 | |
| A | ARG1758 | |
| A | GLU1763 |
| site_id | SWS_FT_FI28 |
| Number of Residues | 4 |
| Details | SITE: Calcium ion selectivity and permeability => ECO:0000250 |
| Chain | Residue | Details |
| A | GLU309 | |
| A | GLU657 | |
| A | GLU1372 | |
| A | GLU1663 |
| site_id | SWS_FT_FI29 |
| Number of Residues | 7 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q61290 |
| Chain | Residue | Details |
| A | SER14 | |
| A | SER19 | |
| A | SER427 | |
| A | SER745 | |
| A | SER815 | |
| A | SER855 | |
| A | SER2094 |
| site_id | SWS_FT_FI30 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q61290 |
| Chain | Residue | Details |
| A | THR440 |
| site_id | SWS_FT_FI31 |
| Number of Residues | 5 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q07652 |
| Chain | Residue | Details |
| A | SER736 | |
| A | SER793 | |
| A | SER947 | |
| A | SER1097 | |
| A | SER2113 |
| site_id | SWS_FT_FI32 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN254 | |
| A | ASN1566 | |
| A | ASN1571 |
