8EPL
Human R-type voltage-gated calcium channel Cav2.3 at 3.1 Angstrom resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005245 | molecular_function | voltage-gated calcium channel activity |
| A | 0005262 | molecular_function | calcium channel activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005891 | cellular_component | voltage-gated calcium channel complex |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006816 | biological_process | calcium ion transport |
| A | 0007268 | biological_process | chemical synaptic transmission |
| A | 0008331 | molecular_function | high voltage-gated calcium channel activity |
| A | 0016020 | cellular_component | membrane |
| A | 0022843 | molecular_function | voltage-gated monoatomic cation channel activity |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0034702 | cellular_component | monoatomic ion channel complex |
| A | 0043025 | cellular_component | neuronal cell body |
| A | 0045202 | cellular_component | synapse |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0070588 | biological_process | calcium ion transmembrane transport |
| A | 0098703 | biological_process | calcium ion import across plasma membrane |
| B | 0005245 | molecular_function | voltage-gated calcium channel activity |
| B | 0005246 | molecular_function | calcium channel regulator activity |
| B | 0005262 | molecular_function | calcium channel activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005891 | cellular_component | voltage-gated calcium channel complex |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0006816 | biological_process | calcium ion transport |
| B | 0007268 | biological_process | chemical synaptic transmission |
| B | 0008331 | molecular_function | high voltage-gated calcium channel activity |
| B | 0016020 | cellular_component | membrane |
| B | 0030315 | cellular_component | T-tubule |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0034702 | cellular_component | monoatomic ion channel complex |
| B | 0045202 | cellular_component | synapse |
| B | 0045933 | biological_process | positive regulation of muscle contraction |
| B | 0060402 | biological_process | calcium ion transport into cytosol |
| B | 0061577 | biological_process | calcium ion transmembrane transport via high voltage-gated calcium channel |
| B | 0070588 | biological_process | calcium ion transmembrane transport |
| B | 0072659 | biological_process | protein localization to plasma membrane |
| B | 0098903 | biological_process | regulation of membrane repolarization during action potential |
| B | 1901843 | biological_process | positive regulation of high voltage-gated calcium channel activity |
| B | 1990454 | cellular_component | L-type voltage-gated calcium channel complex |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 18 |
| Details | Transmembrane: {"description":"Helical; Name=S1 of repeat I"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 373 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 18 |
| Details | Transmembrane: {"description":"Helical; Name=S2 of repeat I"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 145 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 14 |
| Details | Transmembrane: {"description":"Helical; Name=S3 of repeat I"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 19 |
| Details | Transmembrane: {"description":"Helical; Name=S4 of repeat I"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=S5 of repeat I"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 23 |
| Details | Transmembrane: {"description":"Helical; Name=S6 of repeat I"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 19 |
| Details | Transmembrane: {"description":"Helical; Name=S1 of repeat II"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 18 |
| Details | Transmembrane: {"description":"Helical; Name=S3 of repeat II"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 18 |
| Details | Transmembrane: {"description":"Helical; Name=S4 of repeat II"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 19 |
| Details | Transmembrane: {"description":"Helical; Name=S5 of repeat II"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 24 |
| Details | Transmembrane: {"description":"Helical; Name=S6 of repeat II"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 16 |
| Details | Transmembrane: {"description":"Helical; Name=S1 of repeat III"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 19 |
| Details | Transmembrane: {"description":"Helical; Name=S2 of repeat III"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 17 |
| Details | Transmembrane: {"description":"Helical; Name=S4 of repeat III"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 19 |
| Details | Transmembrane: {"description":"Helical; Name=S5 of repeat III"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 23 |
| Details | Transmembrane: {"description":"Helical; Name=S6 of repeat III"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 18 |
| Details | Transmembrane: {"description":"Helical; Name=S1 of repeat IV"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI20 |
| Number of Residues | 19 |
| Details | Transmembrane: {"description":"Helical; Name=S2 of repeat IV"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI21 |
| Number of Residues | 18 |
| Details | Transmembrane: {"description":"Helical; Name=S3 of repeat IV"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI22 |
| Number of Residues | 18 |
| Details | Transmembrane: {"description":"Helical; Name=S4 of repeat IV"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI23 |
| Number of Residues | 19 |
| Details | Transmembrane: {"description":"Helical; Name=S5 of repeat IV"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI24 |
| Number of Residues | 25 |
| Details | Transmembrane: {"description":"Helical; Name=S6 of repeat IV"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI25 |
| Number of Residues | 263 |
| Details | Repeat: {"description":"IV"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI26 |
| Number of Residues | 35 |
| Details | Domain: {"description":"EF-hand","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI27 |
| Number of Residues | 17 |
| Details | Region: {"description":"Binding to the beta subunit","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI28 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI29 |
| Number of Residues | 4 |
| Details | Site: {"description":"Calcium ion selectivity and permeability","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI30 |
| Number of Residues | 11 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI31 |
| Number of Residues | 69 |
| Details | Domain: {"description":"SH3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00192","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI32 |
| Number of Residues | 41 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI33 |
| Number of Residues | 150 |
| Details | Region: {"description":"Mediates interaction with the alpha subunit","evidences":[{"source":"UniProtKB","id":"P54287","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI34 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P54287","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI35 |
| Number of Residues | 177 |
| Details | Domain: {"description":"VWFA","evidences":[{"source":"PROSITE-ProRule","id":"PRU00219","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI36 |
| Number of Residues | 4 |
| Details | Motif: {"description":"MIDAS-like motif"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI37 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI38 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P54290","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI39 |
| Number of Residues | 7 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"34234349","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MIX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MIY","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
