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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8ENE

Aldehyde dehydrogenase 1 family member A1 from human liver

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0001523biological_processretinoid metabolic process
A0001758molecular_functionretinal dehydrogenase (NAD+) activity
A0004029molecular_functionaldehyde dehydrogenase (NAD+) activity
A0005096molecular_functionGTPase activator activity
A0005497molecular_functionandrogen binding
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006081biological_processaldehyde metabolic process
A0006629biological_processlipid metabolic process
A0009449biological_processgamma-aminobutyric acid biosynthetic process
A0016491molecular_functionoxidoreductase activity
A0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
A0018479molecular_functionbenzaldehyde dehydrogenase (NAD+) activity
A0019145molecular_functionaminobutyraldehyde dehydrogenase (NAD+) activity
A0030392biological_processfructosamine catabolic process
A0030424cellular_componentaxon
A0036438biological_processmaintenance of lens transparency
A0042572biological_processretinol metabolic process
A0045202cellular_componentsynapse
A0051287molecular_functionNAD binding
A0070062cellular_componentextracellular exosome
A0106373molecular_function3-deoxyglucosone dehydrogenase activity
A0110095biological_processcellular detoxification of aldehyde
A0120163biological_processnegative regulation of cold-induced thermogenesis
A0140087molecular_functionacetaldehyde dehydrogenase (NAD+) activity
B0000166molecular_functionnucleotide binding
B0001523biological_processretinoid metabolic process
B0001758molecular_functionretinal dehydrogenase (NAD+) activity
B0004029molecular_functionaldehyde dehydrogenase (NAD+) activity
B0005096molecular_functionGTPase activator activity
B0005497molecular_functionandrogen binding
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006081biological_processaldehyde metabolic process
B0006629biological_processlipid metabolic process
B0009449biological_processgamma-aminobutyric acid biosynthetic process
B0016491molecular_functionoxidoreductase activity
B0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
B0018479molecular_functionbenzaldehyde dehydrogenase (NAD+) activity
B0019145molecular_functionaminobutyraldehyde dehydrogenase (NAD+) activity
B0030392biological_processfructosamine catabolic process
B0030424cellular_componentaxon
B0036438biological_processmaintenance of lens transparency
B0042572biological_processretinol metabolic process
B0045202cellular_componentsynapse
B0051287molecular_functionNAD binding
B0070062cellular_componentextracellular exosome
B0106373molecular_function3-deoxyglucosone dehydrogenase activity
B0110095biological_processcellular detoxification of aldehyde
B0120163biological_processnegative regulation of cold-induced thermogenesis
B0140087molecular_functionacetaldehyde dehydrogenase (NAD+) activity
C0000166molecular_functionnucleotide binding
C0001523biological_processretinoid metabolic process
C0001758molecular_functionretinal dehydrogenase (NAD+) activity
C0004029molecular_functionaldehyde dehydrogenase (NAD+) activity
C0005096molecular_functionGTPase activator activity
C0005497molecular_functionandrogen binding
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006081biological_processaldehyde metabolic process
C0006629biological_processlipid metabolic process
C0009449biological_processgamma-aminobutyric acid biosynthetic process
C0016491molecular_functionoxidoreductase activity
C0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
C0018479molecular_functionbenzaldehyde dehydrogenase (NAD+) activity
C0019145molecular_functionaminobutyraldehyde dehydrogenase (NAD+) activity
C0030392biological_processfructosamine catabolic process
C0030424cellular_componentaxon
C0036438biological_processmaintenance of lens transparency
C0042572biological_processretinol metabolic process
C0045202cellular_componentsynapse
C0051287molecular_functionNAD binding
C0070062cellular_componentextracellular exosome
C0106373molecular_function3-deoxyglucosone dehydrogenase activity
C0110095biological_processcellular detoxification of aldehyde
C0120163biological_processnegative regulation of cold-induced thermogenesis
C0140087molecular_functionacetaldehyde dehydrogenase (NAD+) activity
D0000166molecular_functionnucleotide binding
D0001523biological_processretinoid metabolic process
D0001758molecular_functionretinal dehydrogenase (NAD+) activity
D0004029molecular_functionaldehyde dehydrogenase (NAD+) activity
D0005096molecular_functionGTPase activator activity
D0005497molecular_functionandrogen binding
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006081biological_processaldehyde metabolic process
D0006629biological_processlipid metabolic process
D0009449biological_processgamma-aminobutyric acid biosynthetic process
D0016491molecular_functionoxidoreductase activity
D0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
D0018479molecular_functionbenzaldehyde dehydrogenase (NAD+) activity
D0019145molecular_functionaminobutyraldehyde dehydrogenase (NAD+) activity
D0030392biological_processfructosamine catabolic process
D0030424cellular_componentaxon
D0036438biological_processmaintenance of lens transparency
D0042572biological_processretinol metabolic process
D0045202cellular_componentsynapse
D0051287molecular_functionNAD binding
D0070062cellular_componentextracellular exosome
D0106373molecular_function3-deoxyglucosone dehydrogenase activity
D0110095biological_processcellular detoxification of aldehyde
D0120163biological_processnegative regulation of cold-induced thermogenesis
D0140087molecular_functionacetaldehyde dehydrogenase (NAD+) activity
Functional Information from PROSITE/UniProt
site_idPS00070
Number of Residues12
DetailsALDEHYDE_DEHYDR_CYS Aldehyde dehydrogenases cysteine active site. FyHQGQCCIAAS
ChainResidueDetails
APHE296-SER307
site_idPS00687
Number of Residues8
DetailsALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. LELGGKSP
ChainResidueDetails
ALEU268-PRO275
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues660
DetailsRegion: {"description":"Mediates interaction with PRMT3","evidences":[{"source":"PubMed","id":"33495566","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues4
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10007","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10008","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"3676276","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues4
DetailsActive site: {"description":"Nucleophile","evidences":[{"source":"PROSITE-ProRule","id":"PRU10007","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10008","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"3676276","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues64
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"25450233","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25634381","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4WB9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4X4L","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues4
DetailsSite: {"description":"Transition state stabilizer","evidences":[{"source":"UniProtKB","id":"P20000","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues36
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues4
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

247536

PDB entries from 2026-01-14

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