8EMT
Cryo-EM analysis of the human aldehyde oxidase from liver
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004031 | molecular_function | aldehyde oxidase activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006805 | biological_process | xenobiotic metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0043546 | molecular_function | molybdopterin cofactor binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| A | 0051287 | molecular_function | NAD binding |
| A | 0051536 | molecular_function | iron-sulfur cluster binding |
| A | 0051537 | molecular_function | 2 iron, 2 sulfur cluster binding |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0071949 | molecular_function | FAD binding |
| B | 0004031 | molecular_function | aldehyde oxidase activity |
| B | 0005506 | molecular_function | iron ion binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0006805 | biological_process | xenobiotic metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0043546 | molecular_function | molybdopterin cofactor binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| B | 0051287 | molecular_function | NAD binding |
| B | 0051536 | molecular_function | iron-sulfur cluster binding |
| B | 0051537 | molecular_function | 2 iron, 2 sulfur cluster binding |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0071949 | molecular_function | FAD binding |
Functional Information from PROSITE/UniProt
| site_id | PS00197 |
| Number of Residues | 9 |
| Details | 2FE2S_FER_1 2Fe-2S ferredoxin-type iron-sulfur binding region signature. CGGGGCGAC |
| Chain | Residue | Details |
| B | CYS44-CYS52 |
| site_id | PS00559 |
| Number of Residues | 36 |
| Details | MOLYBDOPTERIN_EUK Eukaryotic molybdopterin oxidoreductases signature. AFggKvlktgiiaavta..FaanKHgraVrCvlERgeD |
| Chain | Residue | Details |
| B | ALA806-ASP841 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor; for azaheterocycle hydroxylase activity => ECO:0000250|UniProtKB:O54754 |
| Chain | Residue | Details |
| B | GLU1270 | |
| A | GLU1270 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26322824, ECO:0007744|PDB:4UHW |
| Chain | Residue | Details |
| B | CYS44 | |
| A | CYS44 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 30 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26322824, ECO:0000269|PubMed:26842593, ECO:0007744|PDB:4UHW, ECO:0007744|PDB:4UHX, ECO:0007744|PDB:5EPG |
| Chain | Residue | Details |
| B | CYS49 | |
| B | ASP367 | |
| B | LEU411 | |
| B | ALA806 | |
| B | MET1047 | |
| B | GLY1088 | |
| B | GLN1203 | |
| A | CYS49 | |
| A | CYS52 | |
| A | CYS74 | |
| A | CYS114 | |
| B | CYS52 | |
| A | CYS117 | |
| A | CYS149 | |
| A | CYS151 | |
| A | VAL264 | |
| A | SER354 | |
| A | ASP367 | |
| A | LEU411 | |
| A | ALA806 | |
| A | MET1047 | |
| A | GLY1088 | |
| B | CYS74 | |
| A | GLN1203 | |
| B | CYS114 | |
| B | CYS117 | |
| B | CYS149 | |
| B | CYS151 | |
| B | VAL264 | |
| B | SER354 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26322824, ECO:0007744|PDB:4UHW, ECO:0007744|PDB:4UHX |
| Chain | Residue | Details |
| B | GLN113 | |
| B | ALA345 | |
| A | GLN113 | |
| A | ALA345 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26322824, ECO:0000269|PubMed:26842593, ECO:0007744|PDB:5EPG |
| Chain | Residue | Details |
| B | HIS358 | |
| A | HIS358 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26322824, ECO:0007744|PDB:4UHX |
| Chain | Residue | Details |
| B | LEU1268 | |
| A | LEU1268 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| B | SER1068 | |
| A | SER1068 |
