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8EMD

Human PU.1 ETS-Domain (165-270) Q226E Mutant Bound to d(AATAAGCGGAAGTGGG)

Functional Information from GO Data
ChainGOidnamespacecontents
F0003700molecular_functionDNA-binding transcription factor activity
F0006355biological_processregulation of DNA-templated transcription
F0006357biological_processregulation of transcription by RNA polymerase II
F0043565molecular_functionsequence-specific DNA binding
Functional Information from PROSITE/UniProt
site_idPS00345
Number of Residues9
DetailsETS_DOMAIN_1 Ets-domain signature 1. LYQFLLDLL
ChainResidueDetails
FLEU172-LEU180

site_idPS00346
Number of Residues16
DetailsETS_DOMAIN_2 Ets-domain signature 2. RkkMtYEkMARALRnY
ChainResidueDetails
FARG220-TYR235

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues83
DetailsDNA_BIND: ETS => ECO:0000255|PROSITE-ProRule:PRU00237
ChainResidueDetails
FILE170-SER253

site_idSWS_FT_FI2
Number of Residues1
DetailsBINDING: forms a salt bridge with the phosphate backbone of the opposite strand downstream of the GGAA core sequence => ECO:0000250|UniProtKB:P17433
ChainResidueDetails
FLYS217

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: contacts bases in the GGAA sequence in the major groove => ECO:0000250|UniProtKB:P17433
ChainResidueDetails
FARG230
FARG233

site_idSWS_FT_FI4
Number of Residues1
DetailsBINDING: contacts the phosphate backbone of the GGAA sequence in the minor groove upstream => ECO:0000250|UniProtKB:P17433
ChainResidueDetails
FLYS243

220472

PDB entries from 2024-05-29

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