Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8EM4

Cryo-EM structure of LRP2 at pH 7.5

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005509	molecular_function	calcium ion binding
B	0005509	molecular_function	calcium ion binding

Functional Information from PROSITE/UniProt

site_id	PS00010
Number of Residues	12
Details	ASX_HYDROXYL Aspartic acid and asparagine hydroxylation site. CvNmrgsFrCaC

Chain	Residue	Details
A	CYS1405-CYS1416
A	CYS3128-CYS3139
A	CYS3169-CYS3180
A	CYS4023-CYS4034

site_id	PS00022
Number of Residues	12
Details	EGF_1 EGF-like domain signature 1. CkCssGysGEyC

Chain	Residue	Details
A	CYS4401-CYS4412

site_id	PS00615
Number of Residues	27
Details	C_TYPE_LECTIN_1 C-type lectin domain signature. CVdidecketpq..LCSQKCenvigsYIC

Chain	Residue	Details
A	CYS3152-CYS3178

site_id	PS01186
Number of Residues	15
Details	EGF_2 EGF-like domain signature 2. ClCeeGYilergqh.C

Chain	Residue	Details
A	CYS370-CYS384
A	CYS688-CYS703
A	CYS1374-CYS1389
A	CYS1726-CYS1741
A	CYS2044-CYS2059
A	CYS3137-CYS3152
A	CYS3178-CYS3193
A	CYS4401-CYS4412

site_id	PS01187
Number of Residues	24
Details	EGF_CA Calcium-binding EGF-like domain signature. DvNECdipgf.........Csqh....CvNmrgsFrC

Chain	Residue	Details
A	ASP1391-CYS1414
A	ASP3154-CYS3178
A	ASP4009-CYS4032

site_id	PS01209
Number of Residues	23
Details	LDLRA_1 LDL-receptor class A (LDLRA) domain signature. CIpaswr.CDgtrDCldd.TDEig...C

Chain	Residue	Details
A	CYS40-CYS62
A	CYS1201-CYS1223
A	CYS1244-CYS1267
A	CYS1284-CYS1306
A	CYS1326-CYS1349
A	CYS2713-CYS2737
A	CYS2754-CYS2776
A	CYS2836-CYS2860
A	CYS2878-CYS2901
A	CYS2920-CYS2945
A	CYS3007-CYS3029
A	CYS80-CYS103
A	CYS3046-CYS3070
A	CYS3089-CYS3111
A	CYS3527-CYS3550
A	CYS3608-CYS3632
A	CYS3649-CYS3673
A	CYS3694-CYS3716
A	CYS3734-CYS3756
A	CYS3773-CYS3795
A	CYS3812-CYS3834
A	CYS3856-CYS3880
A	CYS120-CYS142
A	CYS3898-CYS3922
A	CYS3942-CYS3964
A	CYS195-CYS217
A	CYS234-CYS256
A	CYS1037-CYS1059
A	CYS1079-CYS1101
A	CYS1122-CYS1144
A	CYS1162-CYS1184

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	72
Details	Domain: {"description":"LDL-receptor class A 6","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	84
Details	Repeat: {"description":"LDL-receptor class B 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	84
Details	Repeat: {"description":"LDL-receptor class B 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	92
Details	Repeat: {"description":"LDL-receptor class B 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	88
Details	Repeat: {"description":"LDL-receptor class B 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	84
Details	Repeat: {"description":"LDL-receptor class B 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	82
Details	Repeat: {"description":"LDL-receptor class B 6","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	86
Details	Repeat: {"description":"LDL-receptor class B 7","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	86
Details	Repeat: {"description":"LDL-receptor class B 8","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	72
Details	Domain: {"description":"LDL-receptor class A 8","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	74
Details	Domain: {"description":"LDL-receptor class A 9","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	72
Details	Domain: {"description":"LDL-receptor class A 10","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	72
Details	Domain: {"description":"LDL-receptor class A 11","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	74
Details	Domain: {"description":"LDL-receptor class A 12","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	76
Details	Domain: {"description":"LDL-receptor class A 13","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	80
Details	Domain: {"description":"EGF-like 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00076","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	78
Details	Domain: {"description":"EGF-like 2; calcium-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00076","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	84
Details	Repeat: {"description":"LDL-receptor class B 9","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	84
Details	Repeat: {"description":"LDL-receptor class B 10","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	86
Details	Repeat: {"description":"LDL-receptor class B 11","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	88
Details	Repeat: {"description":"LDL-receptor class B 12","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	80
Details	Repeat: {"description":"LDL-receptor class B 13","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	84
Details	Repeat: {"description":"LDL-receptor class B 14","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	98
Details	Repeat: {"description":"LDL-receptor class B 15","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	94
Details	Repeat: {"description":"LDL-receptor class B 16","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI26
Number of Residues	82
Details	Repeat: {"description":"LDL-receptor class B 17","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI27
Number of Residues	80
Details	Repeat: {"description":"LDL-receptor class B 18","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI28
Number of Residues	98
Details	Repeat: {"description":"LDL-receptor class B 19","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI29
Number of Residues	88
Details	Repeat: {"description":"LDL-receptor class B 20","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI30
Number of Residues	86
Details	Repeat: {"description":"LDL-receptor class B 21","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI31
Number of Residues	86
Details	Repeat: {"description":"LDL-receptor class B 22","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI32
Number of Residues	84
Details	Repeat: {"description":"LDL-receptor class B 23","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI33
Number of Residues	92
Details	Repeat: {"description":"LDL-receptor class B 24","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI34
Number of Residues	80
Details	Repeat: {"description":"LDL-receptor class B 25","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI35
Number of Residues	86
Details	Repeat: {"description":"LDL-receptor class B 26","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI36
Number of Residues	82
Details	Repeat: {"description":"LDL-receptor class B 27","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI37
Number of Residues	82
Details	Repeat: {"description":"LDL-receptor class B 28","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI38
Number of Residues	76
Details	Domain: {"description":"LDL-receptor class A 16","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI39
Number of Residues	72
Details	Domain: {"description":"LDL-receptor class A 17","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI40
Number of Residues	72
Details	Domain: {"description":"LDL-receptor class A 25","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI41
Number of Residues	82
Details	Domain: {"description":"EGF-like 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00076","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI42
Number of Residues	80
Details	Domain: {"description":"EGF-like 4; calcium-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00076","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI43
Number of Residues	84
Details	Repeat: {"description":"LDL-receptor class B 29","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI44
Number of Residues	84
Details	Repeat: {"description":"LDL-receptor class B 30","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI45
Number of Residues	86
Details	Repeat: {"description":"LDL-receptor class B 31","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI46
Number of Residues	84
Details	Repeat: {"description":"LDL-receptor class B 32","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI47
Number of Residues	80
Details	Repeat: {"description":"LDL-receptor class B 33","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI48
Number of Residues	76
Details	Domain: {"description":"LDL-receptor class A 26","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI49
Number of Residues	76
Details	Domain: {"description":"LDL-receptor class A 27","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI50
Number of Residues	76
Details	Domain: {"description":"LDL-receptor class A 28","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI51
Number of Residues	76
Details	Domain: {"description":"LDL-receptor class A 29","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI52
Number of Residues	76
Details	Domain: {"description":"LDL-receptor class A 30","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI53
Number of Residues	74
Details	Domain: {"description":"LDL-receptor class A 31","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI54
Number of Residues	72
Details	Domain: {"description":"LDL-receptor class A 32","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI55
Number of Residues	72
Details	Domain: {"description":"LDL-receptor class A 33","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI56
Number of Residues	82
Details	Domain: {"description":"EGF-like 5; calcium-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00076","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI57
Number of Residues	84
Details	Repeat: {"description":"LDL-receptor class B 34","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI58
Number of Residues	86
Details	Repeat: {"description":"LDL-receptor class B 35","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI59
Number of Residues	82
Details	Repeat: {"description":"LDL-receptor class B 36","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI60
Number of Residues	68
Details	Domain: {"description":"EGF-like 6","evidences":[{"source":"PROSITE-ProRule","id":"PRU00076","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI61
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P98164","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI62
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P98158","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI63
Number of Residues	62
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI64
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)