8EM2
Cryo-EM structure of the human GDH/6PGL endoplasmic bifunctional protein
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004345 | molecular_function | glucose-6-phosphate dehydrogenase activity |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006006 | biological_process | glucose metabolic process |
| A | 0006098 | biological_process | pentose-phosphate shunt |
| A | 0016614 | molecular_function | oxidoreductase activity, acting on CH-OH group of donors |
| A | 0017057 | molecular_function | 6-phosphogluconolactonase activity |
| A | 0050661 | molecular_function | NADP binding |
| B | 0004345 | molecular_function | glucose-6-phosphate dehydrogenase activity |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0006006 | biological_process | glucose metabolic process |
| B | 0006098 | biological_process | pentose-phosphate shunt |
| B | 0016614 | molecular_function | oxidoreductase activity, acting on CH-OH group of donors |
| B | 0017057 | molecular_function | 6-phosphogluconolactonase activity |
| B | 0050661 | molecular_function | NADP binding |
Functional Information from PROSITE/UniProt
| site_id | PS00069 |
| Number of Residues | 7 |
| Details | G6P_DEHYDROGENASE Glucose-6-phosphate dehydrogenase active site. DHYLGKQ |
| Chain | Residue | Details |
| A | ASP203-GLN209 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"UniProtKB","id":"P11411","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 36 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P11413","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q8CFX1","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
