8ELC

Human JNK2 bound to covalent inhibitor YL2056

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000165	biological_process	MAPK cascade
A	0000166	molecular_function	nucleotide binding
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0004705	molecular_function	JUN kinase activity
A	0004707	molecular_function	MAP kinase activity
A	0004712	molecular_function	protein serine/threonine/tyrosine kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006468	biological_process	protein phosphorylation
A	0007254	biological_process	JNK cascade
A	0010628	biological_process	positive regulation of gene expression
A	0010744	biological_process	positive regulation of macrophage derived foam cell differentiation
A	0016301	molecular_function	kinase activity
A	0016607	cellular_component	nuclear speck
A	0016740	molecular_function	transferase activity
A	0031398	biological_process	positive regulation of protein ubiquitination
A	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
A	0034614	biological_process	cellular response to reactive oxygen species
A	0038095	biological_process	Fc-epsilon receptor signaling pathway
A	0042752	biological_process	regulation of circadian rhythm
A	0046686	biological_process	response to cadmium ion
A	0048511	biological_process	rhythmic process
A	0050804	biological_process	modulation of chemical synaptic transmission
A	0061833	biological_process	protein localization to tricellular tight junction
A	0071803	biological_process	positive regulation of podosome assembly
A	0090398	biological_process	cellular senescence
A	0090594	biological_process	inflammatory response to wounding
A	0097190	biological_process	apoptotic signaling pathway
A	0098685	cellular_component	Schaffer collateral - CA1 synapse
A	0106310	molecular_function	protein serine kinase activity
A	1900017	biological_process	positive regulation of cytokine production involved in inflammatory response
A	2001235	biological_process	positive regulation of apoptotic signaling pathway

Functional Information from PROSITE/UniProt

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDLKpsNIVV

Chain	Residue	Details
A	ILE147-VAL159

---

site_id	PS01351
Number of Residues	103
Details	MAPK MAP kinase signature. FqnqthakrayRElvllkcvnhkniisllnvftpqktleefqdvylvmelmdanlcqvihmeldhermsyllyqmlcgikhlhsagiih..........RDlKpsnivvksdC

Chain	Residue	Details
A	PHE61-CYS163

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	295
Details	Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Motif: {"description":"TXY"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine; by MAP2K7","evidences":[{"source":"PubMed","id":"11062067","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine; by MAP2K4","evidences":[{"source":"PubMed","id":"11062067","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---