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8ELC

Human JNK2 bound to covalent inhibitor YL2056

Functional Information from GO Data
ChainGOidnamespacecontents
A0000165biological_processMAPK cascade
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004705molecular_functionJUN kinase activity
A0004707molecular_functionMAP kinase activity
A0004712molecular_functionprotein serine/threonine/tyrosine kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006468biological_processprotein phosphorylation
A0007254biological_processJNK cascade
A0010628biological_processpositive regulation of gene expression
A0010744biological_processpositive regulation of macrophage derived foam cell differentiation
A0016607cellular_componentnuclear speck
A0031398biological_processpositive regulation of protein ubiquitination
A0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
A0034614biological_processcellular response to reactive oxygen species
A0038095biological_processFc-epsilon receptor signaling pathway
A0042752biological_processregulation of circadian rhythm
A0046686biological_processresponse to cadmium ion
A0048511biological_processrhythmic process
A0050804biological_processmodulation of chemical synaptic transmission
A0061833biological_processprotein localization to tricellular tight junction
A0071276biological_processcellular response to cadmium ion
A0071803biological_processpositive regulation of podosome assembly
A0090398biological_processcellular senescence
A0090594biological_processinflammatory response to wounding
A0097190biological_processapoptotic signaling pathway
A0098685cellular_componentSchaffer collateral - CA1 synapse
A0106310molecular_functionprotein serine kinase activity
A1900017biological_processpositive regulation of cytokine production involved in inflammatory response
A2001235biological_processpositive regulation of apoptotic signaling pathway
Functional Information from PROSITE/UniProt
site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDLKpsNIVV
ChainResidueDetails
AILE147-VAL159

site_idPS01351
Number of Residues103
DetailsMAPK MAP kinase signature. FqnqthakrayRElvllkcvnhkniisllnvftpqktleefqdvylvmelmdanlcqvihmeldhermsyllyqmlcgikhlhsagiih..........RDlKpsnivvksdC
ChainResidueDetails
APHE61-CYS163

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027
ChainResidueDetails
AASP151

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
AILE32
ALYS55

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by MAP2K7 => ECO:0000269|PubMed:11062067
ChainResidueDetails
ATHR183

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphotyrosine; by MAP2K4 => ECO:0000269|PubMed:11062067
ChainResidueDetails
ATYR185

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PDB entries from 2024-06-12

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