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8EL9

Cryo-EM structure of human catalase

Functional Information from GO Data
ChainGOidnamespacecontents
A0000302biological_processresponse to reactive oxygen species
A0001649biological_processosteoblast differentiation
A0001657biological_processureteric bud development
A0001666biological_processresponse to hypoxia
A0001822biological_processkidney development
A0004046molecular_functionaminoacylase activity
A0004096molecular_functioncatalase activity
A0004601molecular_functionperoxidase activity
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005777cellular_componentperoxisome
A0005778cellular_componentperoxisomal membrane
A0005782cellular_componentperoxisomal matrix
A0005829cellular_componentcytosol
A0005925cellular_componentfocal adhesion
A0006641biological_processtriglyceride metabolic process
A0006979biological_processresponse to oxidative stress
A0008203biological_processcholesterol metabolic process
A0009060biological_processaerobic respiration
A0009410biological_processresponse to xenobiotic stimulus
A0009411biological_processresponse to UV
A0009636biological_processresponse to toxic substance
A0009642biological_processresponse to light intensity
A0009650biological_processUV protection
A0010193biological_processresponse to ozone
A0010288biological_processresponse to lead ion
A0014823biological_processresponse to activity
A0014854biological_processresponse to inactivity
A0016020cellular_componentmembrane
A0016209molecular_functionantioxidant activity
A0016684molecular_functionoxidoreductase activity, acting on peroxide as acceptor
A0019899molecular_functionenzyme binding
A0020027biological_processhemoglobin metabolic process
A0020037molecular_functionheme binding
A0032355biological_processresponse to estradiol
A0032868biological_processresponse to insulin
A0032991cellular_componentprotein-containing complex
A0033189biological_processresponse to vitamin A
A0033197biological_processresponse to vitamin E
A0033591biological_processresponse to L-ascorbic acid
A0034774cellular_componentsecretory granule lumen
A0042542biological_processresponse to hydrogen peroxide
A0042744biological_processhydrogen peroxide catabolic process
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0043066biological_processnegative regulation of apoptotic process
A0043231cellular_componentintracellular membrane-bounded organelle
A0045471biological_processresponse to ethanol
A0046686biological_processresponse to cadmium ion
A0046872molecular_functionmetal ion binding
A0050661molecular_functionNADP binding
A0051781biological_processpositive regulation of cell division
A0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0055093biological_processresponse to hyperoxia
A0061692biological_processcellular detoxification of hydrogen peroxide
A0062151cellular_componentcatalase complex
A0070062cellular_componentextracellular exosome
A0070542biological_processresponse to fatty acid
A0071363biological_processcellular response to growth factor stimulus
A0080184biological_processresponse to phenylpropanoid
A1904813cellular_componentficolin-1-rich granule lumen
B0000302biological_processresponse to reactive oxygen species
B0001649biological_processosteoblast differentiation
B0001657biological_processureteric bud development
B0001666biological_processresponse to hypoxia
B0001822biological_processkidney development
B0004046molecular_functionaminoacylase activity
B0004096molecular_functioncatalase activity
B0004601molecular_functionperoxidase activity
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005777cellular_componentperoxisome
B0005778cellular_componentperoxisomal membrane
B0005782cellular_componentperoxisomal matrix
B0005829cellular_componentcytosol
B0005925cellular_componentfocal adhesion
B0006641biological_processtriglyceride metabolic process
B0006979biological_processresponse to oxidative stress
B0008203biological_processcholesterol metabolic process
B0009060biological_processaerobic respiration
B0009410biological_processresponse to xenobiotic stimulus
B0009411biological_processresponse to UV
B0009636biological_processresponse to toxic substance
B0009642biological_processresponse to light intensity
B0009650biological_processUV protection
B0010193biological_processresponse to ozone
B0010288biological_processresponse to lead ion
B0014823biological_processresponse to activity
B0014854biological_processresponse to inactivity
B0016020cellular_componentmembrane
B0016209molecular_functionantioxidant activity
B0016684molecular_functionoxidoreductase activity, acting on peroxide as acceptor
B0019899molecular_functionenzyme binding
B0020027biological_processhemoglobin metabolic process
B0020037molecular_functionheme binding
B0032355biological_processresponse to estradiol
B0032868biological_processresponse to insulin
B0032991cellular_componentprotein-containing complex
B0033189biological_processresponse to vitamin A
B0033197biological_processresponse to vitamin E
B0033591biological_processresponse to L-ascorbic acid
B0034774cellular_componentsecretory granule lumen
B0042542biological_processresponse to hydrogen peroxide
B0042744biological_processhydrogen peroxide catabolic process
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0043066biological_processnegative regulation of apoptotic process
B0043231cellular_componentintracellular membrane-bounded organelle
B0045471biological_processresponse to ethanol
B0046686biological_processresponse to cadmium ion
B0046872molecular_functionmetal ion binding
B0050661molecular_functionNADP binding
B0051781biological_processpositive regulation of cell division
B0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B0055093biological_processresponse to hyperoxia
B0061692biological_processcellular detoxification of hydrogen peroxide
B0062151cellular_componentcatalase complex
B0070062cellular_componentextracellular exosome
B0070542biological_processresponse to fatty acid
B0071363biological_processcellular response to growth factor stimulus
B0080184biological_processresponse to phenylpropanoid
B1904813cellular_componentficolin-1-rich granule lumen
C0000302biological_processresponse to reactive oxygen species
C0001649biological_processosteoblast differentiation
C0001657biological_processureteric bud development
C0001666biological_processresponse to hypoxia
C0001822biological_processkidney development
C0004046molecular_functionaminoacylase activity
C0004096molecular_functioncatalase activity
C0004601molecular_functionperoxidase activity
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005777cellular_componentperoxisome
C0005778cellular_componentperoxisomal membrane
C0005782cellular_componentperoxisomal matrix
C0005829cellular_componentcytosol
C0005925cellular_componentfocal adhesion
C0006641biological_processtriglyceride metabolic process
C0006979biological_processresponse to oxidative stress
C0008203biological_processcholesterol metabolic process
C0009060biological_processaerobic respiration
C0009410biological_processresponse to xenobiotic stimulus
C0009411biological_processresponse to UV
C0009636biological_processresponse to toxic substance
C0009642biological_processresponse to light intensity
C0009650biological_processUV protection
C0010193biological_processresponse to ozone
C0010288biological_processresponse to lead ion
C0014823biological_processresponse to activity
C0014854biological_processresponse to inactivity
C0016020cellular_componentmembrane
C0016209molecular_functionantioxidant activity
C0016684molecular_functionoxidoreductase activity, acting on peroxide as acceptor
C0019899molecular_functionenzyme binding
C0020027biological_processhemoglobin metabolic process
C0020037molecular_functionheme binding
C0032355biological_processresponse to estradiol
C0032868biological_processresponse to insulin
C0032991cellular_componentprotein-containing complex
C0033189biological_processresponse to vitamin A
C0033197biological_processresponse to vitamin E
C0033591biological_processresponse to L-ascorbic acid
C0034774cellular_componentsecretory granule lumen
C0042542biological_processresponse to hydrogen peroxide
C0042744biological_processhydrogen peroxide catabolic process
C0042802molecular_functionidentical protein binding
C0042803molecular_functionprotein homodimerization activity
C0043066biological_processnegative regulation of apoptotic process
C0043231cellular_componentintracellular membrane-bounded organelle
C0045471biological_processresponse to ethanol
C0046686biological_processresponse to cadmium ion
C0046872molecular_functionmetal ion binding
C0050661molecular_functionNADP binding
C0051781biological_processpositive regulation of cell division
C0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
C0055093biological_processresponse to hyperoxia
C0061692biological_processcellular detoxification of hydrogen peroxide
C0062151cellular_componentcatalase complex
C0070062cellular_componentextracellular exosome
C0070542biological_processresponse to fatty acid
C0071363biological_processcellular response to growth factor stimulus
C0080184biological_processresponse to phenylpropanoid
C1904813cellular_componentficolin-1-rich granule lumen
D0000302biological_processresponse to reactive oxygen species
D0001649biological_processosteoblast differentiation
D0001657biological_processureteric bud development
D0001666biological_processresponse to hypoxia
D0001822biological_processkidney development
D0004046molecular_functionaminoacylase activity
D0004096molecular_functioncatalase activity
D0004601molecular_functionperoxidase activity
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005777cellular_componentperoxisome
D0005778cellular_componentperoxisomal membrane
D0005782cellular_componentperoxisomal matrix
D0005829cellular_componentcytosol
D0005925cellular_componentfocal adhesion
D0006641biological_processtriglyceride metabolic process
D0006979biological_processresponse to oxidative stress
D0008203biological_processcholesterol metabolic process
D0009060biological_processaerobic respiration
D0009410biological_processresponse to xenobiotic stimulus
D0009411biological_processresponse to UV
D0009636biological_processresponse to toxic substance
D0009642biological_processresponse to light intensity
D0009650biological_processUV protection
D0010193biological_processresponse to ozone
D0010288biological_processresponse to lead ion
D0014823biological_processresponse to activity
D0014854biological_processresponse to inactivity
D0016020cellular_componentmembrane
D0016209molecular_functionantioxidant activity
D0016684molecular_functionoxidoreductase activity, acting on peroxide as acceptor
D0019899molecular_functionenzyme binding
D0020027biological_processhemoglobin metabolic process
D0020037molecular_functionheme binding
D0032355biological_processresponse to estradiol
D0032868biological_processresponse to insulin
D0032991cellular_componentprotein-containing complex
D0033189biological_processresponse to vitamin A
D0033197biological_processresponse to vitamin E
D0033591biological_processresponse to L-ascorbic acid
D0034774cellular_componentsecretory granule lumen
D0042542biological_processresponse to hydrogen peroxide
D0042744biological_processhydrogen peroxide catabolic process
D0042802molecular_functionidentical protein binding
D0042803molecular_functionprotein homodimerization activity
D0043066biological_processnegative regulation of apoptotic process
D0043231cellular_componentintracellular membrane-bounded organelle
D0045471biological_processresponse to ethanol
D0046686biological_processresponse to cadmium ion
D0046872molecular_functionmetal ion binding
D0050661molecular_functionNADP binding
D0051781biological_processpositive regulation of cell division
D0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
D0055093biological_processresponse to hyperoxia
D0061692biological_processcellular detoxification of hydrogen peroxide
D0062151cellular_componentcatalase complex
D0070062cellular_componentextracellular exosome
D0070542biological_processresponse to fatty acid
D0071363biological_processcellular response to growth factor stimulus
D0080184biological_processresponse to phenylpropanoid
D1904813cellular_componentficolin-1-rich granule lumen
Functional Information from PROSITE/UniProt
site_idPS00437
Number of Residues9
DetailsCATALASE_1 Catalase proximal heme-ligand signature. RLFAYpDTH
ChainResidueDetails
AARG354-HIS362

site_idPS00438
Number of Residues17
DetailsCATALASE_2 Catalase proximal active site signature. FdReripERvvHakGAG
ChainResidueDetails
APHE64-GLY80

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsACT_SITE: ACT_SITE => ECO:0000305|PubMed:10656833
ChainResidueDetails
AHIS75
AASN148
BHIS75
BASN148
CHIS75
CASN148
DHIS75
DASN148

site_idSWS_FT_FI2
Number of Residues24
DetailsBINDING: BINDING => ECO:0000269|PubMed:10656833, ECO:0007744|PDB:1DGB, ECO:0007744|PDB:1DGF, ECO:0007744|PDB:1DGG, ECO:0007744|PDB:1DGH
ChainResidueDetails
AHIS194
ASER201
AARG203
AASN213
ATRP303
AHIS305
BHIS194
BSER201
BARG203
BASN213
BTRP303
BHIS305
CHIS194
CSER201
CARG203
CASN213
CTRP303
CHIS305
DHIS194
DSER201
DARG203
DASN213
DTRP303
DHIS305

site_idSWS_FT_FI3
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:10656833, ECO:0007744|PDB:1DGB, ECO:0007744|PDB:1DGF, ECO:0007744|PDB:1DGH
ChainResidueDetails
ALYS237
BLYS237
CLYS237
DLYS237

site_idSWS_FT_FI4
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:10656833, ECO:0007744|PDB:1DGF
ChainResidueDetails
ALYS306
BLYS306
CLYS306
DLYS306

site_idSWS_FT_FI5
Number of Residues4
DetailsBINDING: axial binding residue => ECO:0000269|PubMed:10656833, ECO:0000269|PubMed:10666617, ECO:0007744|PDB:1DGB, ECO:0007744|PDB:1DGF, ECO:0007744|PDB:1DGG, ECO:0007744|PDB:1DGH, ECO:0007744|PDB:1F4J, ECO:0007744|PDB:1QQW
ChainResidueDetails
ATYR358
BTYR358
CTYR358
DTYR358

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: N-acetylalanine => ECO:0007744|PubMed:25944712
ChainResidueDetails
AALA2
BALA2
CALA2
DALA2

site_idSWS_FT_FI7
Number of Residues12
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER9
ASER422
ASER517
BSER9
BSER422
BSER517
CSER9
CSER422
CSER517
DSER9
DSER422
DSER517

site_idSWS_FT_FI8
Number of Residues4
DetailsMOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P24270
ChainResidueDetails
ALYS221
BLYS221
CLYS221
DLYS221

site_idSWS_FT_FI9
Number of Residues8
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P24270
ChainResidueDetails
ALYS233
ALYS499
BLYS233
BLYS499
CLYS233
CLYS499
DLYS233
DLYS499

site_idSWS_FT_FI10
Number of Residues8
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P24270
ChainResidueDetails
ALYS306
ALYS480
BLYS306
BLYS480
CLYS306
CLYS480
DLYS306
DLYS480

site_idSWS_FT_FI11
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P24270
ChainResidueDetails
ASER417
BSER417
CSER417
DSER417

site_idSWS_FT_FI12
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ATHR511
BTHR511
CTHR511
DTHR511

site_idSWS_FT_FI13
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER515
BSER515
CSER515
DSER515

219869

PDB entries from 2024-05-15

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