8EL7

CryoEM structure of Resistance to Inhibitors of Cholinesterase-8B (Ric-8B) in complex with G alpha s

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001678	biological_process	intracellular glucose homeostasis
A	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
A	0003091	biological_process	renal water homeostasis
A	0003924	molecular_function	GTPase activity
A	0003925	molecular_function	G protein activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005834	cellular_component	heterotrimeric G-protein complex
A	0005886	cellular_component	plasma membrane
A	0007165	biological_process	signal transduction
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
A	0007190	biological_process	activation of adenylate cyclase activity
A	0007191	biological_process	adenylate cyclase-activating dopamine receptor signaling pathway
A	0007192	biological_process	adenylate cyclase-activating serotonin receptor signaling pathway
A	0007608	biological_process	sensory perception of smell
A	0010856	molecular_function	adenylate cyclase activator activity
A	0014819	biological_process	regulation of skeletal muscle contraction
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0019001	molecular_function	guanyl nucleotide binding
A	0031683	molecular_function	G-protein beta/gamma-subunit complex binding
A	0031748	molecular_function	D1 dopamine receptor binding
A	0032024	biological_process	positive regulation of insulin secretion
A	0032588	cellular_component	trans-Golgi network membrane
A	0034695	biological_process	response to prostaglandin E
A	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
A	0038184	biological_process	adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway
A	0046872	molecular_function	metal ion binding
A	0046907	biological_process	intracellular transport
A	0048589	biological_process	developmental growth
A	0050890	biological_process	cognition
A	0060348	biological_process	bone development
A	0060789	biological_process	hair follicle placode formation
A	0070062	cellular_component	extracellular exosome
A	0070527	biological_process	platelet aggregation
A	0071377	biological_process	cellular response to glucagon stimulus
A	0071380	biological_process	cellular response to prostaglandin E stimulus
A	0071468	biological_process	cellular response to acidic pH
A	0071870	biological_process	cellular response to catecholamine stimulus
A	0071880	biological_process	adenylate cyclase-activating adrenergic receptor signaling pathway
A	0097700	biological_process	vascular endothelial cell response to laminar fluid shear stress
A	0120162	biological_process	positive regulation of cold-induced thermogenesis
B	0001965	molecular_function	G-protein alpha-subunit binding
B	0005085	molecular_function	guanyl-nucleotide exchange factor activity
B	0005737	cellular_component	cytoplasm
B	0005813	cellular_component	centrosome
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0005938	cellular_component	cell cortex
B	0006457	biological_process	protein folding
B	0007186	biological_process	G protein-coupled receptor signaling pathway
B	0007608	biological_process	sensory perception of smell
B	0044183	molecular_function	protein folding chaperone

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	7
Details	Region: {"description":"G4 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P04896","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)"}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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