8EKY

Cryo-EM structure of the human PRDX4-ErP46 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016209	molecular_function	antioxidant activity
A	0016491	molecular_function	oxidoreductase activity
A	0051920	molecular_function	peroxiredoxin activity
B	0016209	molecular_function	antioxidant activity
B	0016491	molecular_function	oxidoreductase activity
B	0051920	molecular_function	peroxiredoxin activity
C	0016209	molecular_function	antioxidant activity
C	0016491	molecular_function	oxidoreductase activity
C	0051920	molecular_function	peroxiredoxin activity
D	0016209	molecular_function	antioxidant activity
D	0016491	molecular_function	oxidoreductase activity
D	0051920	molecular_function	peroxiredoxin activity
E	0016209	molecular_function	antioxidant activity
E	0016491	molecular_function	oxidoreductase activity
E	0051920	molecular_function	peroxiredoxin activity
F	0016209	molecular_function	antioxidant activity
F	0016491	molecular_function	oxidoreductase activity
F	0051920	molecular_function	peroxiredoxin activity
G	0016209	molecular_function	antioxidant activity
G	0016491	molecular_function	oxidoreductase activity
G	0051920	molecular_function	peroxiredoxin activity
H	0016209	molecular_function	antioxidant activity
H	0016491	molecular_function	oxidoreductase activity
H	0051920	molecular_function	peroxiredoxin activity
I	0016209	molecular_function	antioxidant activity
I	0016491	molecular_function	oxidoreductase activity
I	0051920	molecular_function	peroxiredoxin activity
J	0016209	molecular_function	antioxidant activity
J	0016491	molecular_function	oxidoreductase activity
J	0051920	molecular_function	peroxiredoxin activity
M	0003756	molecular_function	protein disulfide isomerase activity

Functional Information from PROSITE/UniProt

site_id	PS00014
Number of Residues	4
Details	ER_TARGET Endoplasmic reticulum targeting sequence. KDEL

Chain	Residue	Details
M	LYS429-LEU432

---

site_id	PS00194
Number of Residues	19
Details	THIOREDOXIN_1 Thioredoxin family active site. FVmFFapWCGHCQrLqptW

Chain	Residue	Details
M	PHE81-TRP99
M	PHE209-TRP227
M	PHE342-TRP360

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1580
Details	Domain: {"description":"Thioredoxin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00691","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	10
Details	Active site: {"description":"Cysteine sulfenic acid (-SOH) intermediate","evidences":[{"source":"PubMed","id":"12059788","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21916849","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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