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8EKP

Apo rat TRPV2 in nanodiscs, state 1

Functional Information from GO Data
ChainGOidnamespacecontents
A0005216molecular_functionmonoatomic ion channel activity
A0005261molecular_functionmonoatomic cation channel activity
A0005262molecular_functioncalcium channel activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006915biological_processapoptotic process
A0008285biological_processnegative regulation of cell population proliferation
A0009266biological_processresponse to temperature stimulus
A0009986cellular_componentcell surface
A0012505cellular_componentendomembrane system
A0016020cellular_componentmembrane
A0030027cellular_componentlamellipodium
A0030424cellular_componentaxon
A0032584cellular_componentgrowth cone membrane
A0042470cellular_componentmelanosome
A0042802molecular_functionidentical protein binding
A0044295cellular_componentaxonal growth cone
A0044297cellular_componentcell body
A0045773biological_processpositive regulation of axon extension
A0055085biological_processtransmembrane transport
A0070588biological_processcalcium ion transmembrane transport
A0090280biological_processpositive regulation of calcium ion import
A0098703biological_processcalcium ion import across plasma membrane
A0120162biological_processpositive regulation of cold-induced thermogenesis
B0005216molecular_functionmonoatomic ion channel activity
B0005261molecular_functionmonoatomic cation channel activity
B0005262molecular_functioncalcium channel activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006915biological_processapoptotic process
B0008285biological_processnegative regulation of cell population proliferation
B0009266biological_processresponse to temperature stimulus
B0009986cellular_componentcell surface
B0012505cellular_componentendomembrane system
B0016020cellular_componentmembrane
B0030027cellular_componentlamellipodium
B0030424cellular_componentaxon
B0032584cellular_componentgrowth cone membrane
B0042470cellular_componentmelanosome
B0042802molecular_functionidentical protein binding
B0044295cellular_componentaxonal growth cone
B0044297cellular_componentcell body
B0045773biological_processpositive regulation of axon extension
B0055085biological_processtransmembrane transport
B0070588biological_processcalcium ion transmembrane transport
B0090280biological_processpositive regulation of calcium ion import
B0098703biological_processcalcium ion import across plasma membrane
B0120162biological_processpositive regulation of cold-induced thermogenesis
C0005216molecular_functionmonoatomic ion channel activity
C0005261molecular_functionmonoatomic cation channel activity
C0005262molecular_functioncalcium channel activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006915biological_processapoptotic process
C0008285biological_processnegative regulation of cell population proliferation
C0009266biological_processresponse to temperature stimulus
C0009986cellular_componentcell surface
C0012505cellular_componentendomembrane system
C0016020cellular_componentmembrane
C0030027cellular_componentlamellipodium
C0030424cellular_componentaxon
C0032584cellular_componentgrowth cone membrane
C0042470cellular_componentmelanosome
C0042802molecular_functionidentical protein binding
C0044295cellular_componentaxonal growth cone
C0044297cellular_componentcell body
C0045773biological_processpositive regulation of axon extension
C0055085biological_processtransmembrane transport
C0070588biological_processcalcium ion transmembrane transport
C0090280biological_processpositive regulation of calcium ion import
C0098703biological_processcalcium ion import across plasma membrane
C0120162biological_processpositive regulation of cold-induced thermogenesis
D0005216molecular_functionmonoatomic ion channel activity
D0005261molecular_functionmonoatomic cation channel activity
D0005262molecular_functioncalcium channel activity
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006915biological_processapoptotic process
D0008285biological_processnegative regulation of cell population proliferation
D0009266biological_processresponse to temperature stimulus
D0009986cellular_componentcell surface
D0012505cellular_componentendomembrane system
D0016020cellular_componentmembrane
D0030027cellular_componentlamellipodium
D0030424cellular_componentaxon
D0032584cellular_componentgrowth cone membrane
D0042470cellular_componentmelanosome
D0042802molecular_functionidentical protein binding
D0044295cellular_componentaxonal growth cone
D0044297cellular_componentcell body
D0045773biological_processpositive regulation of axon extension
D0055085biological_processtransmembrane transport
D0070588biological_processcalcium ion transmembrane transport
D0090280biological_processpositive regulation of calcium ion import
D0098703biological_processcalcium ion import across plasma membrane
D0120162biological_processpositive regulation of cold-induced thermogenesis
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2136
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
AMET1-ARG392
CTYR455-ARG460
CARG517-LEU537
CALA643-PRO761
DMET1-ARG392
DTYR455-ARG460
DARG517-LEU537
DALA643-PRO761
ATYR455-ARG460
AARG517-LEU537
AALA643-PRO761
BMET1-ARG392
BTYR455-ARG460
BARG517-LEU537
BALA643-PRO761
CMET1-ARG392

site_idSWS_FT_FI2
Number of Residues480
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
APHE393-HIS413
BTRP496-THR516
BLEU538-LEU558
BVAL622-ILE642
CPHE393-HIS413
CLEU434-TRP454
CLEU461-LEU481
CTRP496-THR516
CLEU538-LEU558
CVAL622-ILE642
DPHE393-HIS413
ALEU434-TRP454
DLEU434-TRP454
DLEU461-LEU481
DTRP496-THR516
DLEU538-LEU558
DVAL622-ILE642
ALEU461-LEU481
ATRP496-THR516
ALEU538-LEU558
AVAL622-ILE642
BPHE393-HIS413
BLEU434-TRP454
BLEU461-LEU481

site_idSWS_FT_FI3
Number of Residues128
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
AGLN414-MET433
ALEU482-GLU495
BGLN414-MET433
BLEU482-GLU495
CGLN414-MET433
CLEU482-GLU495
DGLN414-MET433
DLEU482-GLU495

site_idSWS_FT_FI4
Number of Residues144
DetailsINTRAMEM: Pore-forming => ECO:0000255
ChainResidueDetails
ASER573-GLU609
BSER573-GLU609
CSER573-GLU609
DSER573-GLU609

site_idSWS_FT_FI5
Number of Residues12
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:22673903
ChainResidueDetails
ASER6
DSER6
DSER82
DSER760
ASER82
ASER760
BSER6
BSER82
BSER760
CSER6
CSER82
CSER760

site_idSWS_FT_FI6
Number of Residues8
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9WTR1
ChainResidueDetails
ASER15
ASER748
BSER15
BSER748
CSER15
CSER748
DSER15
DSER748

site_idSWS_FT_FI7
Number of Residues8
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN571
AASN572
BASN571
BASN572
CASN571
CASN572
DASN571
DASN572

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PDB entries from 2024-11-06

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