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8EHW

cryo-EM structure of TMEM63A in nanodisc

Functional Information from GO Data
ChainGOidnamespacecontents
A0003676molecular_functionnucleic acid binding
A0005227molecular_functioncalcium-activated cation channel activity
A0005515molecular_functionprotein binding
A0005764cellular_componentlysosome
A0005765cellular_componentlysosomal membrane
A0005768cellular_componentendosome
A0005886cellular_componentplasma membrane
A0008381molecular_functionmechanosensitive monoatomic ion channel activity
A0016020cellular_componentmembrane
A0031901cellular_componentearly endosome membrane
A0034220biological_processmonoatomic ion transmembrane transport
A0034451cellular_componentcentriolar satellite
A0035579cellular_componentspecific granule membrane
A0043231cellular_componentintracellular membrane-bounded organelle
A0070062cellular_componentextracellular exosome
A0070821cellular_componenttertiary granule membrane
A0098655biological_processmonoatomic cation transmembrane transport
A0160069biological_processsurfactant secretion
A1990760molecular_functionosmolarity-sensing monoatomic cation channel activity
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues200
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
AILE50-ILE70
ALEU698-GLY718
AILE146-LEU166
AASP191-MET211
ALEU423-LEU443
AILE462-ILE482
AILE508-PHE528
AGLY553-LEU573
AVAL620-LEU640
APHE665-PHE685

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q91YT8
ChainResidueDetails
ASER739

site_idSWS_FT_FI3
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498
ChainResidueDetails
AASN38
AASN450

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PDB entries from 2024-07-17

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