8EHW
cryo-EM structure of TMEM63A in nanodisc
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0005227 | molecular_function | calcium-activated cation channel activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005764 | cellular_component | lysosome |
| A | 0005765 | cellular_component | lysosomal membrane |
| A | 0005768 | cellular_component | endosome |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0007040 | biological_process | lysosome organization |
| A | 0008381 | molecular_function | mechanosensitive monoatomic ion channel activity |
| A | 0016020 | cellular_component | membrane |
| A | 0017128 | molecular_function | phospholipid scramblase activity |
| A | 0031901 | cellular_component | early endosome membrane |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0034451 | cellular_component | centriolar satellite |
| A | 0035579 | cellular_component | specific granule membrane |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070821 | cellular_component | tertiary granule membrane |
| A | 0098655 | biological_process | monoatomic cation transmembrane transport |
| A | 0160069 | biological_process | surfactant secretion |
| A | 1990760 | molecular_function | osmolarity-sensing monoatomic cation channel activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=TM0","evidences":[{"source":"PubMed","id":"38217391","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37543036","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8EHW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WUA","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 32 |
| Details | Transmembrane: {"description":"Helical; Name=TM1","evidences":[{"source":"PubMed","id":"38217391","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37543036","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8EHW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WUA","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 68 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"38217391","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37543036","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8EHW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WUA","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 25 |
| Details | Transmembrane: {"description":"Helical; Name=TM2","evidences":[{"source":"PubMed","id":"38217391","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37543036","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8EHW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WUA","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 27 |
| Details | Transmembrane: {"description":"Helical; Name=TM3","evidences":[{"source":"PubMed","id":"38217391","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37543036","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8EHW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WUA","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 27 |
| Details | Transmembrane: {"description":"Helical; Name=TM4","evidences":[{"source":"PubMed","id":"38217391","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37543036","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8EHW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WUA","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 32 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"38217391","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37543036","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8EHW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WUA","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 36 |
| Details | Transmembrane: {"description":"Helical; Name=TM5","evidences":[{"source":"PubMed","id":"38217391","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37543036","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8EHW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WUA","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 31 |
| Details | Transmembrane: {"description":"Helical; Name=TM6","evidences":[{"source":"PubMed","id":"38217391","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37543036","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8EHW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WUA","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 17 |
| Details | Transmembrane: {"description":"Helical; Name=TM7","evidences":[{"source":"PubMed","id":"38217391","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37543036","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8EHW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WUA","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=TM8","evidences":[{"source":"PubMed","id":"38217391","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37543036","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8EHW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WUA","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 27 |
| Details | Transmembrane: {"description":"Helical; Name=TM9","evidences":[{"source":"PubMed","id":"38217391","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37543036","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8EHW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WUA","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 14 |
| Details | Transmembrane: {"description":"Helical; Name=TM10","evidences":[{"source":"PubMed","id":"38217391","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37543036","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8EHW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WUA","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 31 |
| Details | Region: {"description":"Gating helix","evidences":[{"source":"PubMed","id":"37543036","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00498","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
