8EFV
Structure of single homo-hexameric Holliday junction ATP-dependent DNA helicase RuvB motor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000400 | molecular_function | four-way junction DNA binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006281 | biological_process | DNA repair |
| A | 0006310 | biological_process | DNA recombination |
| A | 0009378 | molecular_function | four-way junction helicase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0032508 | biological_process | DNA duplex unwinding |
| A | 0048476 | cellular_component | Holliday junction resolvase complex |
| B | 0000400 | molecular_function | four-way junction DNA binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006281 | biological_process | DNA repair |
| B | 0006310 | biological_process | DNA recombination |
| B | 0009378 | molecular_function | four-way junction helicase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016887 | molecular_function | ATP hydrolysis activity |
| B | 0032508 | biological_process | DNA duplex unwinding |
| B | 0048476 | cellular_component | Holliday junction resolvase complex |
| C | 0000400 | molecular_function | four-way junction DNA binding |
| C | 0003677 | molecular_function | DNA binding |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006281 | biological_process | DNA repair |
| C | 0006310 | biological_process | DNA recombination |
| C | 0009378 | molecular_function | four-way junction helicase activity |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0016887 | molecular_function | ATP hydrolysis activity |
| C | 0032508 | biological_process | DNA duplex unwinding |
| C | 0048476 | cellular_component | Holliday junction resolvase complex |
| D | 0000400 | molecular_function | four-way junction DNA binding |
| D | 0003677 | molecular_function | DNA binding |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006281 | biological_process | DNA repair |
| D | 0006310 | biological_process | DNA recombination |
| D | 0009378 | molecular_function | four-way junction helicase activity |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0016887 | molecular_function | ATP hydrolysis activity |
| D | 0032508 | biological_process | DNA duplex unwinding |
| D | 0048476 | cellular_component | Holliday junction resolvase complex |
| E | 0000400 | molecular_function | four-way junction DNA binding |
| E | 0003677 | molecular_function | DNA binding |
| E | 0005524 | molecular_function | ATP binding |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0006281 | biological_process | DNA repair |
| E | 0006310 | biological_process | DNA recombination |
| E | 0009378 | molecular_function | four-way junction helicase activity |
| E | 0016787 | molecular_function | hydrolase activity |
| E | 0016887 | molecular_function | ATP hydrolysis activity |
| E | 0032508 | biological_process | DNA duplex unwinding |
| E | 0048476 | cellular_component | Holliday junction resolvase complex |
| F | 0000400 | molecular_function | four-way junction DNA binding |
| F | 0003677 | molecular_function | DNA binding |
| F | 0005524 | molecular_function | ATP binding |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0006281 | biological_process | DNA repair |
| F | 0006310 | biological_process | DNA recombination |
| F | 0009378 | molecular_function | four-way junction helicase activity |
| F | 0016787 | molecular_function | hydrolase activity |
| F | 0016887 | molecular_function | ATP hydrolysis activity |
| F | 0032508 | biological_process | DNA duplex unwinding |
| F | 0048476 | cellular_component | Holliday junction resolvase complex |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11171970, ECO:0000269|PubMed:12408833, ECO:0000312|PDB:1HQC, ECO:0000312|PDB:1IXS |
| Chain | Residue | Details |
| D | TYR14 | |
| C | TYR14 | |
| B | TYR14 | |
| A | TYR14 | |
| F | TYR14 | |
| E | TYR14 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11171970, ECO:0000312|PDB:1HQC, ECO:0000312|PDB:1IXS |
| Chain | Residue | Details |
| D | ILE15 | |
| C | ILE15 | |
| B | ILE15 | |
| A | ILE15 | |
| F | ILE15 | |
| E | ILE15 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00016, ECO:0000269|PubMed:12408833, ECO:0000312|PDB:1IXR |
| Chain | Residue | Details |
| D | GLY48 | |
| C | GLY48 | |
| B | GLY48 | |
| A | GLY48 | |
| F | GLY48 | |
| E | GLY48 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00016, ECO:0000269|PubMed:12408833, ECO:0000312|PDB:1IXR, ECO:0000312|PDB:1IXS |
| Chain | Residue | Details |
| D | LYS51 | |
| F | THR53 | |
| E | LYS51 | |
| E | THR53 | |
| D | THR53 | |
| C | LYS51 | |
| C | THR53 | |
| B | LYS51 | |
| B | THR53 | |
| A | LYS51 | |
| A | THR53 | |
| F | LYS51 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 18 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00016 |
| Chain | Residue | Details |
| D | THR52 | |
| A | THR52 | |
| A | ARG297 | |
| A | ARG302 | |
| F | THR52 | |
| F | ARG297 | |
| F | ARG302 | |
| E | THR52 | |
| E | ARG297 | |
| E | ARG302 | |
| D | ARG297 | |
| D | ARG302 | |
| C | THR52 | |
| C | ARG297 | |
| C | ARG302 | |
| B | THR52 | |
| B | ARG297 | |
| B | ARG302 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:12408833 |
| Chain | Residue | Details |
| D | ASP97 | |
| F | THR146 | |
| E | ASP97 | |
| E | THR146 | |
| D | THR146 | |
| C | ASP97 | |
| C | THR146 | |
| B | ASP97 | |
| B | THR146 | |
| A | ASP97 | |
| A | THR146 | |
| F | ASP97 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00016, ECO:0000269|PubMed:11171970, ECO:0000269|PubMed:12408833, ECO:0000312|PDB:1HQC, ECO:0000312|PDB:1IXS |
| Chain | Residue | Details |
| D | TYR168 | |
| C | TYR168 | |
| B | TYR168 | |
| A | TYR168 | |
| F | TYR168 | |
| E | TYR168 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00016, ECO:0000305|PubMed:12408833 |
| Chain | Residue | Details |
| D | ARG205 | |
| C | ARG205 | |
| B | ARG205 | |
| A | ARG205 | |
| F | ARG205 | |
| E | ARG205 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 780 |
| Chain | Residue | Details |
| D | LYS51 | |
| D | THR52 | |
| D | ASP97 | |
| D | THR146 | electrostatic stabiliser |
| D | ARG205 | electrostatic stabiliser |
| site_id | MCSA2 |
| Number of Residues | 5 |
| Details | M-CSA 780 |
| Chain | Residue | Details |
| C | LYS51 | |
| C | THR52 | |
| C | ASP97 | |
| C | THR146 | electrostatic stabiliser |
| C | ARG205 | electrostatic stabiliser |
| site_id | MCSA3 |
| Number of Residues | 5 |
| Details | M-CSA 780 |
| Chain | Residue | Details |
| B | LYS51 | |
| B | THR52 | |
| B | ASP97 | |
| B | THR146 | electrostatic stabiliser |
| B | ARG205 | electrostatic stabiliser |
| site_id | MCSA4 |
| Number of Residues | 5 |
| Details | M-CSA 780 |
| Chain | Residue | Details |
| A | LYS51 | |
| A | THR52 | |
| A | ASP97 | |
| A | THR146 | electrostatic stabiliser |
| A | ARG205 | electrostatic stabiliser |
| site_id | MCSA5 |
| Number of Residues | 5 |
| Details | M-CSA 780 |
| Chain | Residue | Details |
| F | LYS51 | |
| F | THR52 | |
| F | ASP97 | |
| F | THR146 | electrostatic stabiliser |
| F | ARG205 | electrostatic stabiliser |
| site_id | MCSA6 |
| Number of Residues | 5 |
| Details | M-CSA 780 |
| Chain | Residue | Details |
| E | LYS51 | |
| E | THR52 | |
| E | ASP97 | |
| E | THR146 | electrostatic stabiliser |
| E | ARG205 | electrostatic stabiliser |
