8EFU

a22L prion fibril

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016020	cellular_component	membrane
A	0051260	biological_process	protein homooligomerization
B	0016020	cellular_component	membrane
B	0051260	biological_process	protein homooligomerization
C	0016020	cellular_component	membrane
C	0051260	biological_process	protein homooligomerization
D	0016020	cellular_component	membrane
D	0051260	biological_process	protein homooligomerization
E	0016020	cellular_component	membrane
E	0051260	biological_process	protein homooligomerization

Functional Information from PROSITE/UniProt

site_id	PS00291
Number of Residues	16
Details	PRION_1 Prion protein signature 1. AGAAAAGAVVGGLGGY

Chain	Residue	Details
A	ALA112-TYR127

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site_id	PS00706
Number of Residues	19
Details	PRION_2 Prion protein signature 2. EtDvKMMeRVVeQMCvtQY

Chain	Residue	Details
A	GLU199-TYR217

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	60
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P04156

Chain	Residue	Details
A	HIS60
A	HIS84
A	GLY85
A	GLY86
B	HIS60
B	GLY61
B	GLY62
B	HIS68
B	GLY69
B	GLY70
B	HIS76
A	GLY61
B	GLY77
B	GLY78
B	HIS84
B	GLY85
B	GLY86
C	HIS60
C	GLY61
C	GLY62
C	HIS68
C	GLY69
A	GLY62
C	GLY70
C	HIS76
C	GLY77
C	GLY78
C	HIS84
C	GLY85
C	GLY86
D	HIS60
D	GLY61
D	GLY62
A	HIS68
D	HIS68
D	GLY69
D	GLY70
D	HIS76
D	GLY77
D	GLY78
D	HIS84
D	GLY85
D	GLY86
E	HIS60
A	GLY69
E	GLY61
E	GLY62
E	HIS68
E	GLY69
E	GLY70
E	HIS76
E	GLY77
E	GLY78
E	HIS84
E	GLY85
A	GLY70
E	GLY86
A	HIS76
A	GLY77
A	GLY78

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site_id	SWS_FT_FI2
Number of Residues	5
Details	MOD_RES: Hydroxyproline => ECO:0000269|PubMed:11032800

Chain	Residue	Details
A	PRO44
B	PRO44
C	PRO44
D	PRO44
E	PRO44

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site_id	SWS_FT_FI3
Number of Residues	5
Details	LIPID: GPI-anchor amidated serine => ECO:0000250|UniProtKB:P04273

Chain	Residue	Details
A	SER230
B	SER230
C	SER230
D	SER230
E	SER230

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site_id	SWS_FT_FI4
Number of Residues	5
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000305

Chain	Residue	Details
A	ASN180
B	ASN180
C	ASN180
D	ASN180
E	ASN180

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site_id	SWS_FT_FI5
Number of Residues	5
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19349973

Chain	Residue	Details
A	ASN196
B	ASN196
C	ASN196
D	ASN196
E	ASN196

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