8EFO

PZM21-bound mu-opioid receptor-Gi complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0001664	molecular_function	G protein-coupled receptor binding
A	0003924	molecular_function	GTPase activity
A	0003925	molecular_function	G protein activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005765	cellular_component	lysosomal membrane
A	0005794	cellular_component	Golgi apparatus
A	0005813	cellular_component	centrosome
A	0005829	cellular_component	cytosol
A	0005834	cellular_component	heterotrimeric G-protein complex
A	0005856	cellular_component	cytoskeleton
A	0005886	cellular_component	plasma membrane
A	0005938	cellular_component	cell cortex
A	0007165	biological_process	signal transduction
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0007188	biological_process	adenylate cyclase-modulating G protein-coupled receptor signaling pathway
A	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
A	0007193	biological_process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
A	0007198	biological_process	adenylate cyclase-inhibiting serotonin receptor signaling pathway
A	0007218	biological_process	neuropeptide signaling pathway
A	0010854	molecular_function	adenylate cyclase regulator activity
A	0010855	molecular_function	adenylate cyclase inhibitor activity
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0019001	molecular_function	guanyl nucleotide binding
A	0019003	molecular_function	GDP binding
A	0030496	cellular_component	midbody
A	0031683	molecular_function	G-protein beta/gamma-subunit complex binding
A	0031749	molecular_function	D2 dopamine receptor binding
A	0031821	molecular_function	G protein-coupled serotonin receptor binding
A	0034451	cellular_component	centriolar satellite
A	0034695	biological_process	response to prostaglandin E
A	0036064	cellular_component	ciliary basal body
A	0043434	biological_process	response to peptide hormone
A	0045542	biological_process	positive regulation of cholesterol biosynthetic process
A	0046676	biological_process	negative regulation of insulin secretion
A	0046872	molecular_function	metal ion binding
A	0051301	biological_process	cell division
A	0060236	biological_process	regulation of mitotic spindle organization
A	0070062	cellular_component	extracellular exosome
A	0070098	biological_process	chemokine-mediated signaling pathway
A	0072678	biological_process	T cell migration
A	1901082	biological_process	positive regulation of relaxation of smooth muscle
A	1904322	biological_process	cellular response to forskolin
A	1904778	biological_process	positive regulation of protein localization to cell cortex
B	0001750	cellular_component	photoreceptor outer segment
B	0001917	cellular_component	photoreceptor inner segment
B	0003924	molecular_function	GTPase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005834	cellular_component	heterotrimeric G-protein complex
B	0005886	cellular_component	plasma membrane
B	0007165	biological_process	signal transduction
B	0007186	biological_process	G protein-coupled receptor signaling pathway
B	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
B	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
B	0008283	biological_process	cell population proliferation
B	0010659	biological_process	cardiac muscle cell apoptotic process
B	0030159	molecular_function	signaling receptor complex adaptor activity
B	0030425	cellular_component	dendrite
B	0030507	molecular_function	spectrin binding
B	0042622	cellular_component	photoreceptor outer segment membrane
B	0044297	cellular_component	cell body
B	0044877	molecular_function	protein-containing complex binding
B	0045202	cellular_component	synapse
B	0047391	molecular_function	alkylglycerophosphoethanolamine phosphodiesterase activity
B	0050909	biological_process	sensory perception of taste
B	0051020	molecular_function	GTPase binding
B	0060041	biological_process	retina development in camera-type eye
B	0071456	biological_process	cellular response to hypoxia
C	0003924	molecular_function	GTPase activity
C	0005515	molecular_function	protein binding
C	0005834	cellular_component	heterotrimeric G-protein complex
C	0005886	cellular_component	plasma membrane
C	0007165	biological_process	signal transduction
C	0007186	biological_process	G protein-coupled receptor signaling pathway
C	0007191	biological_process	adenylate cyclase-activating dopamine receptor signaling pathway
C	0016020	cellular_component	membrane
C	0031681	molecular_function	G-protein beta-subunit binding
C	0071380	biological_process	cellular response to prostaglandin E stimulus
C	0071870	biological_process	cellular response to catecholamine stimulus
F	0000166	molecular_function	nucleotide binding
F	0000287	molecular_function	magnesium ion binding
F	0001664	molecular_function	G protein-coupled receptor binding
F	0003924	molecular_function	GTPase activity
F	0003925	molecular_function	G protein activity
F	0005515	molecular_function	protein binding
F	0005525	molecular_function	GTP binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005730	cellular_component	nucleolus
F	0005737	cellular_component	cytoplasm
F	0005765	cellular_component	lysosomal membrane
F	0005794	cellular_component	Golgi apparatus
F	0005813	cellular_component	centrosome
F	0005829	cellular_component	cytosol
F	0005834	cellular_component	heterotrimeric G-protein complex
F	0005856	cellular_component	cytoskeleton
F	0005886	cellular_component	plasma membrane
F	0005938	cellular_component	cell cortex
F	0007165	biological_process	signal transduction
F	0007186	biological_process	G protein-coupled receptor signaling pathway
F	0007188	biological_process	adenylate cyclase-modulating G protein-coupled receptor signaling pathway
F	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
F	0007193	biological_process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
F	0007198	biological_process	adenylate cyclase-inhibiting serotonin receptor signaling pathway
F	0007218	biological_process	neuropeptide signaling pathway
F	0010854	molecular_function	adenylate cyclase regulator activity
F	0010855	molecular_function	adenylate cyclase inhibitor activity
F	0016020	cellular_component	membrane
F	0016787	molecular_function	hydrolase activity
F	0019001	molecular_function	guanyl nucleotide binding
F	0019003	molecular_function	GDP binding
F	0030496	cellular_component	midbody
F	0031683	molecular_function	G-protein beta/gamma-subunit complex binding
F	0031749	molecular_function	D2 dopamine receptor binding
F	0031821	molecular_function	G protein-coupled serotonin receptor binding
F	0034451	cellular_component	centriolar satellite
F	0034695	biological_process	response to prostaglandin E
F	0036064	cellular_component	ciliary basal body
F	0043434	biological_process	response to peptide hormone
F	0045542	biological_process	positive regulation of cholesterol biosynthetic process
F	0046676	biological_process	negative regulation of insulin secretion
F	0046872	molecular_function	metal ion binding
F	0051301	biological_process	cell division
F	0060236	biological_process	regulation of mitotic spindle organization
F	0070062	cellular_component	extracellular exosome
F	0070098	biological_process	chemokine-mediated signaling pathway
F	0072678	biological_process	T cell migration
F	1901082	biological_process	positive regulation of relaxation of smooth muscle
F	1904322	biological_process	cellular response to forskolin
F	1904778	biological_process	positive regulation of protein localization to cell cortex
M	0001965	molecular_function	G-protein alpha-subunit binding
M	0004930	molecular_function	G protein-coupled receptor activity
M	0004979	molecular_function	beta-endorphin receptor activity
M	0004985	molecular_function	G protein-coupled opioid receptor activity
M	0005245	molecular_function	voltage-gated calcium channel activity
M	0005515	molecular_function	protein binding
M	0005737	cellular_component	cytoplasm
M	0005768	cellular_component	endosome
M	0005783	cellular_component	endoplasmic reticulum
M	0005794	cellular_component	Golgi apparatus
M	0005886	cellular_component	plasma membrane
M	0007165	biological_process	signal transduction
M	0007186	biological_process	G protein-coupled receptor signaling pathway
M	0007187	biological_process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
M	0007197	biological_process	adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway
M	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
M	0007218	biological_process	neuropeptide signaling pathway
M	0007600	biological_process	sensory perception
M	0008285	biological_process	negative regulation of cell population proliferation
M	0008528	molecular_function	G protein-coupled peptide receptor activity
M	0016020	cellular_component	membrane
M	0019233	biological_process	sensory perception of pain
M	0030424	cellular_component	axon
M	0030425	cellular_component	dendrite
M	0031681	molecular_function	G-protein beta-subunit binding
M	0038003	biological_process	G protein-coupled opioid receptor signaling pathway
M	0038047	molecular_function	morphine receptor activity
M	0042923	molecular_function	neuropeptide binding
M	0042995	cellular_component	cell projection
M	0043005	cellular_component	neuron projection
M	0043204	cellular_component	perikaryon
M	0045202	cellular_component	synapse
M	0048149	biological_process	behavioral response to ethanol
M	0050769	biological_process	positive regulation of neurogenesis
M	0061358	biological_process	negative regulation of Wnt protein secretion
M	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
M	0070588	biological_process	calcium ion transmembrane transport
M	0071315	biological_process	cellular response to morphine
M	0080135	biological_process	regulation of cellular response to stress
M	2000310	biological_process	regulation of NMDA receptor activity
R	0001965	molecular_function	G-protein alpha-subunit binding
R	0004930	molecular_function	G protein-coupled receptor activity
R	0004979	molecular_function	beta-endorphin receptor activity
R	0004985	molecular_function	G protein-coupled opioid receptor activity
R	0005245	molecular_function	voltage-gated calcium channel activity
R	0005515	molecular_function	protein binding
R	0005737	cellular_component	cytoplasm
R	0005768	cellular_component	endosome
R	0005783	cellular_component	endoplasmic reticulum
R	0005794	cellular_component	Golgi apparatus
R	0005886	cellular_component	plasma membrane
R	0007165	biological_process	signal transduction
R	0007186	biological_process	G protein-coupled receptor signaling pathway
R	0007187	biological_process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
R	0007197	biological_process	adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway
R	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
R	0007218	biological_process	neuropeptide signaling pathway
R	0007600	biological_process	sensory perception
R	0008285	biological_process	negative regulation of cell population proliferation
R	0008528	molecular_function	G protein-coupled peptide receptor activity
R	0016020	cellular_component	membrane
R	0019233	biological_process	sensory perception of pain
R	0030424	cellular_component	axon
R	0030425	cellular_component	dendrite
R	0031681	molecular_function	G-protein beta-subunit binding
R	0038003	biological_process	G protein-coupled opioid receptor signaling pathway
R	0038047	molecular_function	morphine receptor activity
R	0042923	molecular_function	neuropeptide binding
R	0042995	cellular_component	cell projection
R	0043005	cellular_component	neuron projection
R	0043204	cellular_component	perikaryon
R	0045202	cellular_component	synapse
R	0048149	biological_process	behavioral response to ethanol
R	0050769	biological_process	positive regulation of neurogenesis
R	0061358	biological_process	negative regulation of Wnt protein secretion
R	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
R	0070588	biological_process	calcium ion transmembrane transport
R	0071315	biological_process	cellular response to morphine
R	0080135	biological_process	regulation of cellular response to stress
R	2000310	biological_process	regulation of NMDA receptor activity

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. TSIfTLCTMSVDRYIaV

Chain	Residue	Details
R	THR155-VAL171

---

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS

Chain	Residue	Details
B	LEU70-SER84
B	ILE157-ILE171
B	LEU285-ALA299

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	48
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"UniProtKB","id":"P42866","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	108
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"UniProtKB","id":"P42866","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	48
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"UniProtKB","id":"P42866","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	78
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"UniProtKB","id":"P42866","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	44
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"UniProtKB","id":"P42866","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	42
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"UniProtKB","id":"P42866","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	48
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"UniProtKB","id":"P42866","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	52
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"UniProtKB","id":"P42866","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	46
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"UniProtKB","id":"P42866","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	8
Details	Motif: {"description":"NPxxY; plays a role in stabilizing the activated conformation of the receptor","evidences":[{"source":"UniProtKB","id":"P42866","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P33535","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	13
Details	Region: {"description":"G1 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	9
Details	Region: {"description":"G3 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	7
Details	Region: {"description":"G4 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	5
Details	Region: {"description":"G5 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21115486","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1KJY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1Y3A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2G83","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GTP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2IK8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2OM2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XNS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ONW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QE0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QI2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UMR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UMS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4G5Q","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18434541","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22383884","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3QE0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21115486","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PDB","id":"1Y3A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2G83","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GTP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2IK8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2OM2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ONW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QE0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QI2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UMR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UMS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4G5Q","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	1
Details	Modified residue: {"description":"Deamidated glutamine; by Photorhabdus PAU_02230","evidences":[{"source":"PubMed","id":"24141704","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	2
Details	Modified residue: {"description":"ADP-ribosylcysteine; by pertussis toxin","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	48
Details	Repeat: {"description":"WD 1","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	45
Details	Repeat: {"description":"WD 2","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	40
Details	Repeat: {"description":"WD 3","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	41
Details	Repeat: {"description":"WD 4","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	43
Details	Repeat: {"description":"WD 5","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	41
Details	Repeat: {"description":"WD 6","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	30
Details	Repeat: {"description":"WD 7","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI29
Number of Residues	1
Details	Modified residue: {"description":"Phosphohistidine","evidences":[{"source":"UniProtKB","id":"P62871","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---