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8EEB

Cryo-EM structure of human ABCA7 in Digitonin

Functional Information from GO Data
ChainGOidnamespacecontents
A0000139cellular_componentGolgi membrane
A0001891cellular_componentphagocytic cup
A0005524molecular_functionATP binding
A0005548molecular_functionphospholipid transporter activity
A0005737cellular_componentcytoplasm
A0005768cellular_componentendosome
A0005783cellular_componentendoplasmic reticulum
A0005794cellular_componentGolgi apparatus
A0005886cellular_componentplasma membrane
A0006869biological_processlipid transport
A0006909biological_processphagocytosis
A0007613biological_processmemory
A0008542biological_processvisual learning
A0009986cellular_componentcell surface
A0010875biological_processpositive regulation of cholesterol efflux
A0016020cellular_componentmembrane
A0016887molecular_functionATP hydrolysis activity
A0018149biological_processpeptide cross-linking
A0019216biological_processregulation of lipid metabolic process
A0030054cellular_componentcell junction
A0031901cellular_componentearly endosome membrane
A0032587cellular_componentruffle membrane
A0033344biological_processcholesterol efflux
A0033700biological_processphospholipid efflux
A0034188molecular_functionapolipoprotein A-I receptor activity
A0034205biological_processamyloid-beta formation
A0034380biological_processhigh-density lipoprotein particle assembly
A0034504biological_processprotein localization to nucleus
A0038027biological_processapolipoprotein A-I-mediated signaling pathway
A0042626molecular_functionATPase-coupled transmembrane transporter activity
A0042985biological_processnegative regulation of amyloid precursor protein biosynthetic process
A0042995cellular_componentcell projection
A0043231cellular_componentintracellular membrane-bounded organelle
A0043409biological_processnegative regulation of MAPK cascade
A0044857biological_processplasma membrane raft organization
A0045332biological_processphospholipid translocation
A0045806biological_processnegative regulation of endocytosis
A0050766biological_processpositive regulation of phagocytosis
A0055085biological_processtransmembrane transport
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0090554molecular_functionphosphatidylcholine floppase activity
A0090556molecular_functionphosphatidylserine floppase activity
A0097386cellular_componentglial cell projection
A0140326molecular_functionATPase-coupled intramembrane lipid transporter activity
A0140328molecular_functionfloppase activity
A0140359molecular_functionABC-type transporter activity
A0150094biological_processamyloid-beta clearance by cellular catabolic process
A1900223biological_processpositive regulation of amyloid-beta clearance
A1901076biological_processpositive regulation of engulfment of apoptotic cell
A1902430biological_processnegative regulation of amyloid-beta formation
A1902991biological_processregulation of amyloid precursor protein catabolic process
A1902995biological_processpositive regulation of phospholipid efflux
A1903898biological_processnegative regulation of PERK-mediated unfolded protein response
A2000010biological_processpositive regulation of protein localization to cell surface
Functional Information from PROSITE/UniProt
site_idPS00211
Number of Residues15
DetailsABC_TRANSPORTER_1 ABC transporters family signature. LSGGMQRKLSVAIAF
ChainResidueDetails
ALEU940-PHE954

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues300
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
APRO22-VAL42
AVAL1538-ILE1558
APHE1584-ALA1604
ALEU1621-PHE1641
AVAL1649-LEU1669
AILE1683-MET1703
AVAL1729-LEU1749
ALEU550-VAL570
ALEU593-VAL613
AGLY626-LEU646
ALEU655-VAL675
AVAL687-LEU707
AVAL727-ALA747
ATHR849-GLY869
AILE1243-PHE1263

site_idSWS_FT_FI2
Number of Residues779
DetailsTOPO_DOM: Extracellular => ECO:0000250
ChainResidueDetails
AARG43-SER549
AGLY1264-LEU1537

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00434
ChainResidueDetails
AGLY841
AGLY1827

site_idSWS_FT_FI4
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN312

222415

PDB entries from 2024-07-10

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