8EE1

KS-AT didomain from module 2 of the 6-deoxyerythronolide B synthase in complex with antibody fragment AA5

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
A	0006633	biological_process	fatty acid biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
D	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
D	0006633	biological_process	fatty acid biosynthetic process
D	0016740	molecular_function	transferase activity
D	0016746	molecular_function	acyltransferase activity

Functional Information from PROSITE/UniProt

site_id	PS00599
Number of Residues	10
Details	AA_TRANSFER_CLASS_2 Aminotransferases class-II pyridoxal-phosphate attachment site. TYGKSRGSSG

Chain	Residue	Details
A	THR355-GLY364

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site_id	PS00606
Number of Residues	17
Details	KS3_1 Ketosynthase family 3 (KS3) active site signature. GPAltVDtACSSSlvAL

Chain	Residue	Details
A	GLY193-LEU209

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site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
B	TYR201-HIS207
C	TYR209-HIS215

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Acyl-thioester intermediate; for beta-ketoacyl synthase 2 activity => ECO:0000255|PROSITE-ProRule:PRU01348

Chain	Residue	Details
A	CYS202
D	CYS202

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site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: For beta-ketoacyl synthase 2 activity => ECO:0000255|PROSITE-ProRule:PRU01348

Chain	Residue	Details
A	HIS337
A	HIS377
D	HIS337
D	HIS377

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site_id	SWS_FT_FI3
Number of Residues	2
Details	ACT_SITE: Acyl-ester intermediate; for acyltransferase 3 activity => ECO:0000250|UniProtKB:Q03133, ECO:0000255|PROSITE-ProRule:PRU10022

Chain	Residue	Details
A	SER652
D	SER652

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