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8EDL

Cryo-EM structure of the full-length human NF1 dimer

Functional Information from GO Data
ChainGOidnamespacecontents
A0000165biological_processMAPK cascade
A0001525biological_processangiogenesis
A0001649biological_processosteoblast differentiation
A0001656biological_processmetanephros development
A0001666biological_processresponse to hypoxia
A0001889biological_processliver development
A0001935biological_processendothelial cell proliferation
A0001937biological_processnegative regulation of endothelial cell proliferation
A0001938biological_processpositive regulation of endothelial cell proliferation
A0001952biological_processregulation of cell-matrix adhesion
A0001953biological_processnegative regulation of cell-matrix adhesion
A0002686biological_processnegative regulation of leukocyte migration
A0005096molecular_functionGTPase activator activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006469biological_processnegative regulation of protein kinase activity
A0006606biological_processprotein import into nucleus
A0006915biological_processapoptotic process
A0007154biological_processcell communication
A0007265biological_processRas protein signal transduction
A0007269biological_processneurotransmitter secretion
A0007405biological_processneuroblast proliferation
A0007406biological_processnegative regulation of neuroblast proliferation
A0007420biological_processbrain development
A0007422biological_processperipheral nervous system development
A0007507biological_processheart development
A0007519biological_processskeletal muscle tissue development
A0008283biological_processcell population proliferation
A0008285biological_processnegative regulation of cell population proliferation
A0008289molecular_functionlipid binding
A0008429molecular_functionphosphatidylethanolamine binding
A0008542biological_processvisual learning
A0008625biological_processextrinsic apoptotic signaling pathway via death domain receptors
A0010468biological_processregulation of gene expression
A0010626biological_processnegative regulation of Schwann cell proliferation
A0014009biological_processglial cell proliferation
A0014010biological_processSchwann cell proliferation
A0014044biological_processSchwann cell development
A0016020cellular_componentmembrane
A0016477biological_processcell migration
A0016525biological_processnegative regulation of angiogenesis
A0016601biological_processRac protein signal transduction
A0021510biological_processspinal cord development
A0021764biological_processamygdala development
A0021897biological_processforebrain astrocyte development
A0021915biological_processneural tube development
A0021987biological_processcerebral cortex development
A0022011biological_processmyelination in peripheral nervous system
A0030036biological_processactin cytoskeleton organization
A0030198biological_processextracellular matrix organization
A0030199biological_processcollagen fibril organization
A0030316biological_processosteoclast differentiation
A0030325biological_processadrenal gland development
A0030336biological_processnegative regulation of cell migration
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0031210molecular_functionphosphatidylcholine binding
A0032228biological_processregulation of synaptic transmission, GABAergic
A0033024biological_processmast cell apoptotic process
A0033027biological_processpositive regulation of mast cell apoptotic process
A0033028biological_processmyeloid cell apoptotic process
A0033034biological_processpositive regulation of myeloid cell apoptotic process
A0034605biological_processcellular response to heat
A0035021biological_processnegative regulation of Rac protein signal transduction
A0036135biological_processSchwann cell migration
A0042060biological_processwound healing
A0042127biological_processregulation of cell population proliferation
A0042308biological_processnegative regulation of protein import into nucleus
A0043065biological_processpositive regulation of apoptotic process
A0043087biological_processregulation of GTPase activity
A0043407biological_processnegative regulation of MAP kinase activity
A0043408biological_processregulation of MAPK cascade
A0043409biological_processnegative regulation of MAPK cascade
A0043473biological_processpigmentation
A0043491biological_processphosphatidylinositol 3-kinase/protein kinase B signal transduction
A0043525biological_processpositive regulation of neuron apoptotic process
A0043535biological_processregulation of blood vessel endothelial cell migration
A0043547biological_processpositive regulation of GTPase activity
A0045124biological_processregulation of bone resorption
A0045671biological_processnegative regulation of osteoclast differentiation
A0045685biological_processregulation of glial cell differentiation
A0045762biological_processpositive regulation of adenylate cyclase activity
A0045765biological_processregulation of angiogenesis
A0046580biological_processnegative regulation of Ras protein signal transduction
A0046929biological_processnegative regulation of neurotransmitter secretion
A0048144biological_processfibroblast proliferation
A0048147biological_processnegative regulation of fibroblast proliferation
A0048169biological_processregulation of long-term neuronal synaptic plasticity
A0048485biological_processsympathetic nervous system development
A0048593biological_processcamera-type eye morphogenesis
A0048708biological_processastrocyte differentiation
A0048709biological_processoligodendrocyte differentiation
A0048712biological_processnegative regulation of astrocyte differentiation
A0048715biological_processnegative regulation of oligodendrocyte differentiation
A0048745biological_processsmooth muscle tissue development
A0048820biological_processhair follicle maturation
A0048844biological_processartery morphogenesis
A0048853biological_processforebrain morphogenesis
A0050890biological_processcognition
A0051402biological_processneuron apoptotic process
A0060253biological_processnegative regulation of glial cell proliferation
A0060291biological_processlong-term synaptic potentiation
A0061534biological_processgamma-aminobutyric acid secretion, neurotransmission
A0061535biological_processglutamate secretion, neurotransmission
A0070372biological_processregulation of ERK1 and ERK2 cascade
A0070662biological_processmast cell proliferation
A0070667biological_processnegative regulation of mast cell proliferation
A0071887biological_processleukocyte apoptotic process
A0072089biological_processstem cell proliferation
A0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
A0097529biological_processmyeloid leukocyte migration
A0098597biological_processobservational learning
A0098793cellular_componentpresynapse
A0098978cellular_componentglutamatergic synapse
A0099175biological_processregulation of postsynapse organization
A1900148biological_processnegative regulation of Schwann cell migration
A1900271biological_processregulation of long-term synaptic potentiation
A1904707biological_processpositive regulation of vascular associated smooth muscle cell proliferation
A1904738biological_processvascular associated smooth muscle cell migration
A1904753biological_processnegative regulation of vascular associated smooth muscle cell migration
A1990874biological_processvascular associated smooth muscle cell proliferation
A2000108biological_processpositive regulation of leukocyte apoptotic process
A2000647biological_processnegative regulation of stem cell proliferation
A2001241biological_processpositive regulation of extrinsic apoptotic signaling pathway in absence of ligand
Functional Information from PROSITE/UniProt
site_idPS00509
Number of Residues15
DetailsRAS_GTPASE_ACTIV_1 Ras GTPase-activating proteins domain signature. SaMFLRFINPAIVSP
ChainResidueDetails
ASER1386-PRO1400

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0000250|UniProtKB:P97526
ChainResidueDetails
AALA2

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER864

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER876

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163
ChainResidueDetails
ALEU2188
ALYS2521

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q04690
ChainResidueDetails
ALEU2467

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q04690
ChainResidueDetails
ALYS2514

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163
ChainResidueDetails
ALYS2515

site_idSWS_FT_FI8
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
APHE2523
ALEU2597
ALYS2802

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
ATHR2543

site_idSWS_FT_FI10
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER2565

site_idSWS_FT_FI11
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:24275569
ChainResidueDetails
AILE2817

226707

PDB entries from 2024-10-30

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